Imperial College London
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Dr Rachel Phillips

Faculty of Medicine, School of Public Health

Senior Lecturer in Medical Statistics and Clinical Trials
 
 
 
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Contact

 

+44 (0)20 7594 8802r.phillips

 
 
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Location

 

Stadium HouseWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Furukawa:2021:10.1136/ebmental-2020-300240,
author = {Furukawa, T and Levine, S and Buntrock, C and Ebert, D and Gilbody, S and Brabyn, S and Kessler, D and Kivi, M and Björkelund, C and Kleiboer, A and van, Straten A and Riper, H and Montero-Marin, J and Garcia-, Campayo J and Phillips, R and Scheider, J and Cuijpers, P and Karyotaki, E},
doi = {10.1136/ebmental-2020-300240},
journal = {Evidence-Based Mental Health},
pages = {97--101},
title = {How can we estimate QALYs based on PHQ-9 scores? Equipercentile linking analysis of PHQ-9 and EQ-5D},
url = {http://dx.doi.org/10.1136/ebmental-2020-300240},
volume = {24},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background Quality-adjusted life years (QALYs) are widely used to measure the impact of various diseases on both the quality and quantity of life and in their economic valuations. It will be clinically important and informative if we can estimate QALYs based on measurements of depression severity.Objective To construct a conversion table from the Patient Health Questionnaire-9 (PHQ-9), the most frequently used depression scale in recent years, to the Euro-Qol Five Dimensions Three Levels (EQ-5D-3L), one of the most commonly used instruments to assess QALYs.Methods We obtained individual participant data of randomised controlled trials of internet cognitive-behavioural therapy which had administered depression severity scales and the EQ-5D-3L at baseline and at end of treatment. Scores from depression scales were all converted into the PHQ-9 according to the validated algorithms. We used equipercentile linking to establish correspondences between the PHQ-9 and the EQ-5D-3L.Findings Individual-level data from five trials (total N=2457) were available. Subthreshold depression (PHQ-9 scores between 5 and 10) corresponded with EQ-5D-3L index values of 0.9–0.8, mild major depression (10–15) with 0.8–0.7, moderate depression (15–20) with 0.7–0.5 and severe depression (20 or higher) with 0.6–0.0. A five-point improvement in PHQ-9 corresponded approximately with an increase in EQ-5D-3L score by 0.03 and a ten-point improvement by approximately 0.25.Conclusions and Clinical Implications The conversion table between the PHQ-9 and the EQ-5D-3L scores will enable fine-grained assessment of burden of depression at its various levels of severity and of impacts of its various treatments.
AU  - Furukawa,T
AU  - Levine,S
AU  - Buntrock,C
AU  - Ebert,D
AU  - Gilbody,S
AU  - Brabyn,S
AU  - Kessler,D
AU  - Kivi,M
AU  - Björkelund,C
AU  - Kleiboer,A
AU  - van,Straten A
AU  - Riper,H
AU  - Montero-Marin,J
AU  - Garcia-,Campayo J
AU  - Phillips,R
AU  - Scheider,J
AU  - Cuijpers,P
AU  - Karyotaki,E
DO  - 10.1136/ebmental-2020-300240
EP  - 101
PY  - 2021///
SN  - 1362-0347
SP  - 97
TI  - How can we estimate QALYs based on PHQ-9 scores? Equipercentile linking analysis of PHQ-9 and EQ-5D
T2  - Evidence-Based Mental Health
UR  - http://dx.doi.org/10.1136/ebmental-2020-300240
UR  - http://hdl.handle.net/10044/1/87557
VL  - 24
ER  -
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