Imperial College London
Alternate

Professor Richard Reynolds, BSc AKC PhD

Faculty of Medicine, Department of Brain Sciences

Professor of Cellular Neurobiology
 
 
 
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Contact

 

+44 (0)20 7594 6668r.reynolds

 
 
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Location

 

E414Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Wang:2020:10.1016/j.cell.2020.09.054,
author = {Wang, J and Jelcic, I and Muhlenbruch, L and Haunerdinger, V and Toussaint, NC and Zhao, Y and Cruciani, C and Faigle, W and Naghavian, R and Foege, M and Binder, TMC and Eiermann, T and Opitz, L and Fuentes-Font, L and Reynolds, R and Kwok, WW and Nguyen, JT and Lee, J-H and Lutterotti, A and Munz, C and Rammensee, H-G and Hauri-Hohl, M and Sospedra, M and Stevanovic, S and Martin, R},
doi = {10.1016/j.cell.2020.09.054},
journal = {Cell},
pages = {1264--1281.e20},
title = {HLA-DR15 molecules jointly shape an autoreactive T cell repertoire in multiple sclerosis},
url = {http://dx.doi.org/10.1016/j.cell.2020.09.054},
volume = {183},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The HLA-DR15 haplotype is the strongest genetic risk factor for multiple sclerosis (MS), but our understanding of how it contributes to MS is limited. Because autoreactive CD4+ T cells and B cells as antigen-presenting cells are involved in MS pathogenesis, we characterized the immunopeptidomes of the two HLA-DR15 allomorphs DR2a and DR2b of human primary B cells and monocytes, thymus, and MS brain tissue. Self-peptides from HLA-DR molecules, particularly from DR2a and DR2b themselves, are abundant on B cells and thymic antigen-presenting cells. Furthermore, we identified autoreactive CD4+ T cell clones that can cross-react with HLA-DR-derived self-peptides (HLA-DR-SPs), peptides from MS-associated foreign agents (Epstein-Barr virus and Akkermansia muciniphila), and autoantigens presented by DR2a and DR2b. Thus, both HLA-DR15 allomorphs jointly shape an autoreactive T cell repertoire by serving as antigen-presenting structures and epitope sources and by presenting the same foreign peptides and autoantigens to autoreactive CD4+ T cells in MS.
AU  - Wang,J
AU  - Jelcic,I
AU  - Muhlenbruch,L
AU  - Haunerdinger,V
AU  - Toussaint,NC
AU  - Zhao,Y
AU  - Cruciani,C
AU  - Faigle,W
AU  - Naghavian,R
AU  - Foege,M
AU  - Binder,TMC
AU  - Eiermann,T
AU  - Opitz,L
AU  - Fuentes-Font,L
AU  - Reynolds,R
AU  - Kwok,WW
AU  - Nguyen,JT
AU  - Lee,J-H
AU  - Lutterotti,A
AU  - Munz,C
AU  - Rammensee,H-G
AU  - Hauri-Hohl,M
AU  - Sospedra,M
AU  - Stevanovic,S
AU  - Martin,R
DO  - 10.1016/j.cell.2020.09.054
EP  - 1281
PY  - 2020///
SN  - 0092-8674
SP  - 1264
TI  - HLA-DR15 molecules jointly shape an autoreactive T cell repertoire in multiple sclerosis
T2  - Cell
UR  - http://dx.doi.org/10.1016/j.cell.2020.09.054
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000593203800011&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.sciencedirect.com/science/article/pii/S0092867420312514?via%3Dihub
UR  - http://hdl.handle.net/10044/1/86507
VL  - 183
ER  -
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