Imperial College London
Alternate

Professor Richard Reynolds, BSc AKC PhD

Faculty of Medicine, Department of Brain Sciences

Professor of Cellular Neurobiology
 
 
 
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Contact

 

+44 (0)20 7594 6668r.reynolds

 
 
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Location

 

E414Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Wang:2021:brain/awab156,
author = {Wang, Q and Luo, Y and Chaudhuri, KR and Reynolds, R and Tan, E-K and Pettersson, S},
doi = {brain/awab156},
journal = {Brain: a journal of neurology},
pages = {2571--2593},
title = {The role of gut dysbiosis in Parkinson's disease: mechanistic insights and therapeutic options.},
url = {http://dx.doi.org/10.1093/brain/awab156},
volume = {144},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Parkinson's disease is a common neurodegenerative disease in which gastrointestinal symptoms may appear prior to motor symptoms. The gut microbiota of patients with Parkinson's disease shows unique changes, which may be used as early biomarkers of disease. Alteration in gut microbiota composition may be related to the cause or effect of motor or non-motor symptoms, but the specific pathogenic mechanisms are unclear. The gut microbiota and its metabolites have been suggested to be involved in the pathogenesis of Parkinson's disease by regulating neuroinflammation, barrier function and neurotransmitter activity. There is bidirectional communication between the enteric nervous system and the central nervous system, and the microbiota-gut-brain axis may provide a pathway for the transmission of α-synuclein. We highlight recent discoveries and alterations of the gut microbiota in Parkinson's disease, and highlight current mechanistic insights on the microbiota-gut-brain axis in disease pathophysiology. We discuss the interactions between production and transmission of α-synuclein and gut inflammation and neuroinflammation. In addition, we also draw attention to diet modification, use of probiotics and prebiotics and fecal microbiota transplantation as potential therapeutic approaches that may lead to a new treatment paradigm for Parkinson's disease.
AU  - Wang,Q
AU  - Luo,Y
AU  - Chaudhuri,KR
AU  - Reynolds,R
AU  - Tan,E-K
AU  - Pettersson,S
DO  - brain/awab156
EP  - 2593
PY  - 2021///
SN  - 0006-8950
SP  - 2571
TI  - The role of gut dysbiosis in Parkinson's disease: mechanistic insights and therapeutic options.
T2  - Brain: a journal of neurology
UR  - http://dx.doi.org/10.1093/brain/awab156
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33856024
UR  - http://hdl.handle.net/10044/1/89071
VL  - 144
ER  -
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