Imperial College London
Alternate

Professor Richard Reynolds, BSc AKC PhD

Faculty of Medicine, Department of Brain Sciences

Professor of Cellular Neurobiology
 
 
 
//

Contact

 

+44 (0)20 7594 6668r.reynolds

 
 
//

Location

 

E414Burlington DanesHammersmith Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Raffel:2017:10.1371/journal.pmed.1002346,
author = {Raffel, J and Wallace, A and Gveric, D and Reynolds, R and Friede, T and Nicholas, R},
doi = {10.1371/journal.pmed.1002346},
journal = {PLOS Medicine},
title = {Patient-reported outcomes and survival in multiple sclerosis: a 10-year retrospective cohort study using the Multiple Sclerosis Impact Scale-29},
url = {http://dx.doi.org/10.1371/journal.pmed.1002346},
volume = {14},
year = {2017}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundThere is increasing emphasis on using patient-reported outcomes (PROs) to complement traditional clinical outcomes in medical research, including in multiple sclerosis (MS). Research, particularly in oncology and heart failure, has shown that PROs can be prognostic of hard clinical endpoints such as survival time (time from study entry until death). However, unlike in oncology or cardiology, it is unknown whether PROs are associated with survival time in neurological diseases. The Multiple Sclerosis Impact Scale–29 (MSIS-29) is a PRO sensitive to short-term change in MS, with questions covering both physical and psychological quality of life. This study aimed to investigate whether MSIS-29 scores can be prognostic for survival time in MS, using a large observational cohort of people with MS.Methods and findingsFrom 15 July 2004 onwards, MSIS-29 questionnaires were completed by people with MS registered with the MS Society Tissue Bank (n = 2,126, repeated 1 year later with n = 872 of the original respondents). By 2014, 264 participants (12.4%) had died. Higher baseline MSIS-29 physical (MSIS-29-PHYS) score was associated with reduced survival time (subgroup with highest scores versus subgroup with lowest scores: hazard ratio [HR] 5.7, 95% CI 3.1–10.5, p < 0.001). Higher baseline MSIS-29 psychological score was also associated with reduced survival time (subgroup with highest scores versus subgroup with lowest scores: HR 2.8, 95% CI 1.8–4.4, p < 0.001). In those with high baseline MSIS-29 scores, mortality risk was even greater if the MSIS-29 score worsened over 1 year (HR 2.3, 95% CI 1.2–4.4, p = 0.02). MSIS-29-PHYS scores were associated with survival time independent of age, sex, and patient-reported Expanded Disability Status Scale score in a Cox regression analysis (per 1-SD increase in MSIS-29-PHYS score: HR 1.8, 95% CI 1.1–2.9, p = 0.03). A limitation of the study is that this cohort had high baseline age and disabi
AU  - Raffel,J
AU  - Wallace,A
AU  - Gveric,D
AU  - Reynolds,R
AU  - Friede,T
AU  - Nicholas,R
DO  - 10.1371/journal.pmed.1002346
PY  - 2017///
SN  - 1549-1277
TI  - Patient-reported outcomes and survival in multiple sclerosis: a 10-year retrospective cohort study using the Multiple Sclerosis Impact Scale-29
T2  - PLOS Medicine
UR  - http://dx.doi.org/10.1371/journal.pmed.1002346
UR  - http://hdl.handle.net/10044/1/49043
VL  - 14
ER  -
Download