Imperial College London
Alternate

Emeritus ProfessorRobertSchroter

Faculty of Engineering, Department of Bioengineering

Emeritus Professor
 
 
 
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Contact

 

+44 (0)20 7594 5175r.schroter

 
 
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Location

 

4.15Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Xiao:2019:10.1007/s10439-019-02410-1,
author = {Xiao, Q and Cetto, R and Doorly, D and Bates, A and Rose, J and McIntyre, C and comerford, A and Madani, G and Tolley, N and Schroter, R},
doi = {10.1007/s10439-019-02410-1},
journal = {Annals of Biomedical Engineering},
pages = {822--833},
title = {Assessing changes in airflow and energy loss in a progressive tracheal compression before and after surgical correction},
url = {http://dx.doi.org/10.1007/s10439-019-02410-1},
volume = {48},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The energy needed to drive airflow through the trachea normally constitutes a minor component of the work ofbreathing. However, with progressive tracheal compression, patient subjective symptoms can include severe breathingdifficulties. Many patients suffer multiple respiratory co-morbidities and so it is important to assess compression effectswhen evaluating the need for surgery. This work describes the use of computational prediction to determine airflowresistance in compressed tracheal geometries reconstructed from a series of CT scans. Using energy flux analysis, theregions that contribute the most to airway resistance during inhalation are identified. The principal such region is where flowemerging from the zone of maximum constriction undergoes breakup and turbulent mixing. Secondary regions are alsofound below the tongue base and around the glottis, with overall airway resistance scaling nearly quadratically with flowrate. Since the anatomical extent of the imaged airway varied between scans - as commonly occurs with clinical data andwhen assessing reported differences between research studies - the effect of sub-glottic inflow truncation is considered.Analysis shows truncation alters the location of jet breakup and weakly influences the pattern of pressure recovery. Testsalso show that placing a simple artificial glottis in the inflow to a truncated model can replicate patterns of energy loss inmore extensive models, suggesting a means to assess sensitivity to domain truncation in tracheal airflow simulations.
AU  - Xiao,Q
AU  - Cetto,R
AU  - Doorly,D
AU  - Bates,A
AU  - Rose,J
AU  - McIntyre,C
AU  - comerford,A
AU  - Madani,G
AU  - Tolley,N
AU  - Schroter,R
DO  - 10.1007/s10439-019-02410-1
EP  - 833
PY  - 2019///
SN  - 0090-6964
SP  - 822
TI  - Assessing changes in airflow and energy loss in a progressive tracheal compression before and after surgical correction
T2  - Annals of Biomedical Engineering
UR  - http://dx.doi.org/10.1007/s10439-019-02410-1
UR  - https://link.springer.com/article/10.1007%2Fs10439-019-02410-1
UR  - http://hdl.handle.net/10044/1/75230
VL  - 48
ER  -
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