Imperial College London

ProfessorRoxySenior

Faculty of MedicineNational Heart & Lung Institute

Professor of Clinical Cardiology
 
 
 
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Contact

 

+44 (0)20 7351 8635r.senior

 
 
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Location

 

Chelsea WingRoyal Brompton Campus

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Summary

 

Publications

Publication Type
Year
to

457 results found

Bangalore S, Spertus JA, Stevens SR, Jones PG, Mancini GBJ, Leipsic J, Reynolds HR, Budoff MJ, Hague CJ, Min JK, Boden WE, O'Brien SM, Harrington RA, Berger JS, Senior R, Peteiro J, Pandit N, Bershtein L, de Belder MA, Szwed H, Doerr R, Monti L, Alfakih K, Hochman JS, Maron DJet al., 2022, Outcomes With Intermediate Left Main Disease: Analysis From the ISCHEMIA Trial, CIRCULATION-CARDIOVASCULAR INTERVENTIONS, Vol: 15, ISSN: 1941-7640

Journal article

Hampson R, Botrous C, Chahal N, Senior Ret al., 2022, Feasibility, efficacy and safety of exercise stress echocardiography during the COVID-19 pandemic, OPEN HEART, Vol: 9, ISSN: 2053-3624

Journal article

Cosyns B, Helfen A, Leong-Poi H, Senior Ret al., 2022, How to perform an ultrasound contrast myocardial perfusion examination?, EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, ISSN: 2047-2404

Journal article

Senior R, Reynolds HR, Min JK, Berman DS, Picard MH, Chaitman BR, Shaw LJ, Page CB, Govindan SC, Lopez-Sendon J, Peteiro J, Wander GS, Drozdz J, Marin-Neto J, Selvanayagam JB, Newman JD, Thuaire C, Christopher J, Jang JJ, Kwong RY, Bangalore S, Stone GW, Brien SM, Boden WE, Maron DJ, Hochman JSet al., 2022, Predictors of Left Main Coronary Artery Disease in the ISCHEMIA Trial, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 79, Pages: 651-661, ISSN: 0735-1097

Journal article

Surkova E, Kovacs A, Lakatos BK, Tokodi M, Fabian A, West C, Senior R, Li Wet al., 2021, Contraction patterns of the systemic right ventricle: a three-dimensional echocardiography study, EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, ISSN: 2047-2404

Journal article

Yakupoglu HY, Saeed S, Senior R, Baksi AJ, Lyon AR, Khattar RSet al., 2021, Reversible exercise-induced left ventricular dysfunction in symptomatic patients with previous Takotsubo syndrome: insights from stress echocardiography, Congress of the European-Society-of-Cardiology (ESC) / World Congress of Cardiology, Publisher: OXFORD UNIV PRESS, Pages: 1405-1412, ISSN: 2047-2404

Conference paper

Vamvakidou A, Danylenko O, Pradhan J, Kelshiker M, Jones T, Whiteside D, Sethi A, Senior Ret al., 2021, Relative clinical value of coronary computed tomography and stress echocardiography-guided management of stable chest pain patients: a propensity-matched analysis, EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, Vol: 22, Pages: 1473-1481, ISSN: 2047-2404

Journal article

Zhou X, Toulemonde M, Zhou X, Hansen-Shearer J, Senior R, Tang M-Xet al., 2021, Volumetric Flow Estimation in a Coronary Artery Phantom Using High-Frame-Rate Contrast-Enhanced Ultrasound, Speckle Decorrelation, and Doppler Flow Direction Detection, IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, Vol: 68, Pages: 3299-3308, ISSN: 0885-3010

Journal article

Vamvakidou A, Annabi M-S, Pibarot P, Plonska-Gosciniak E, Almeida AG, Guzzetti E, Dahou A, Burwash IG, Koschutnik M, Bartko PE, Bergler-Klein J, Mascherbauer J, Orwat S, Baumgartner H, Cavalcante J, Pinto F, Kukulski T, Kasprzak JD, Clavel M-A, Flachskampf FA, Senior Ret al., 2021, Clinical Value of Stress Transaortic Flow Rate During Dobutamine Echocardiography in Reduced Left Ventricular Ejection Fraction, Low-Gradient Aortic Stenosis: A Multicenter Study, CIRCULATION-CARDIOVASCULAR IMAGING, Vol: 14, ISSN: 1941-9651

Journal article

Jenkins S, Alabed S, Swift A, Marques G, Ryding A, Sawh C, Wardley J, Shah BN, Swoboda P, Senior R, Nijveldt R, Vassiliou VS, Garg Pet al., 2021, Diagnostic accuracy of handheld cardiac ultrasound device for assessment of left ventricular structure and function: systematic review and meta-analysis, HEART, Vol: 107, Pages: 1826-1834, ISSN: 1355-6037

Journal article

Bioh G, Botrous C, Howard E, Patel A, Hampson R, Senior Ret al., 2021, Prevalence of cardiac pathology and relation to mortality in a multiethnic population hospitalised with COVID-19, OPEN HEART, Vol: 8, ISSN: 2053-3624

Journal article

Newman JD, Anthopolos R, Mancini GBJ, Bangalore S, Reynolds HR, Kunichoff DF, Senior R, Peteiro J, Bhargava B, Garg P, Escobedo J, Doerr R, Mazurek T, Gonzalez-Juanatey J, Gajos G, Briguori C, Cheng H, Vertes A, Mahajan S, Guzman LA, Keltai M, Maggioni AP, Stone GW, Berger JS, Rosenberg YD, Boden WE, Chaitman BR, Fleg JL, Hochman JS, Maron DJet al., 2021, Outcomes of Participants With Diabetes in the ISCHEMIA Trials, CIRCULATION, Vol: 144, Pages: 1380-1395, ISSN: 0009-7322

Journal article

Seitler S, Al-Sakini N, Lacerna A, Flick C, West C, Senior R, Gatzoulis MA, Li Wet al., 2021, Long term outcomes for adults with complete atrioventricular septal defects, Publisher: OXFORD UNIV PRESS, Pages: 1874-1874, ISSN: 0195-668X

Conference paper

Shah BN, Senior R, 2021, Discordant moderate aortic stenosis: is it clinically important?, OPEN HEART, Vol: 8, ISSN: 2053-3624

Journal article

Reynolds HR, Picard MH, Spertus JA, Peteiro J, Lopez Sendon JL, Senior R, El-Hajjar MC, Celutkiene J, Shapiro MD, Pellikka PA, Kunichoff DF, Anthopolos R, Alfakih K, Abdul-Nour K, Khouri M, Bershtein L, De Belder M, Poh KK, Beltrame JF, Min JK, Fleg JL, Li Y, Maron DJ, Hochman JSet al., 2021, Natural History of Patients With Ischemia and No Obstructive Coronary Artery Disease The CIAO-ISCHEMIA Study, CIRCULATION, Vol: 144, Pages: 1008-1023, ISSN: 0009-7322

Journal article

Senior R, Khattar R, 2021, Stress echocardiography: the quest for risk stratification beyond myocardial ischaemia, EUROPEAN HEART JOURNAL, Vol: 42, Pages: 3879-3881, ISSN: 0195-668X

Journal article

Agostini D, Ananthasubramaniam K, Chandna H, Friberg L, Hudnut A, Koren M, Miyamoto MI, Senior R, Shah M, Travin MI, vom Dahl J, Chen K, Levy WCet al., 2021, Prognostic usefulness of planar I-123-MIBG scintigraphic images of myocardial sympathetic innervation in congestive heart failure: Follow-Up data from ADMIRE-HF, JOURNAL OF NUCLEAR CARDIOLOGY, Vol: 28, Pages: 1490-1503, ISSN: 1071-3581

Journal article

Chahal NS, Senior R, 2021, Severe Patient-Prosthesis Mismatch Compelling Entity or an Epiphenomenon of Low Flow?, CIRCULATION-CARDIOVASCULAR IMAGING, Vol: 14, ISSN: 1941-9651

Journal article

Lindner JR, Belcik T, Main ML, Montanaro A, Mulvagh SL, Olson J, Olyaei A, Porter TR, Senior Ret al., 2021, Expert Consensus Statement from the American Society of Echocardiography on Hypersensitivity Reactions to Ultrasound Enhancing Agents in Patients with Allergy to Polyethylene Glycol, JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY, Vol: 34, Pages: 707-708, ISSN: 0894-7317

Journal article

Senior R, Lindner JR, Edvardsen T, Cosyns Bet al., 2021, Ultrasound contrast agent hypersensitivity in patients allergic to polyethylene glycol: position statement by the European Association of Cardiovascular Imaging, EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, Vol: 22, Pages: 959-960, ISSN: 2047-2404

Journal article

Woodward W, Dockerill C, McCourt A, Upton R, O'Driscoll J, Balkhausen K, Chandrasekaran B, Firoozan S, Kardos A, Wong K, Woodward G, Sarwar R, Sabharwal N, Benedetto E, Spagou N, Sharma R, Augustine D, Tsiachristas A, Senior R, Leeson P, Boardman H, D'Arcy J, Abraheem A, Banypersad S, Boos C, Bulugahapitiya S, Butts J, Coles D, Easaw J, Hamdan H, Jamil-Copley S, Kanaganayagam G, Mwambingu T, Pantazis A, Papachristidis A, Rajani R, Rasheed MA, Razvi NA, Rekhraj S, Ripley DP, Rose K, Scheuermann-Freestone M, Schofield R, Sultan Aet al., 2021, Real-world performance and accuracy of stress echocardiography: the EVAREST observational multi-centre study, EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, Vol: 23, Pages: 689-698, ISSN: 2047-2404

Journal article

Khattar RS, Senior R, 2021, Stress Echocardiography and Carotid Ultrasound: Combined Use for the Assessment of Coronary Artery Disease?, JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY, Vol: 34, Pages: 625-628, ISSN: 0894-7317

Journal article

Radhakrishnan A, Pickup L, Price A, Law J, Fabritz L, Senior R, Richard P, Ferro C, Townend Jet al., 2021, MYOCARDIAL FIBROSIS IS ASSOCIATED WITH REDUCED CORONARY FLOW VELOCITY RESERVE IN END-STAGE RENAL DISEASE, Publisher: BMJ PUBLISHING GROUP, Pages: A123-A125, ISSN: 1355-6037

Conference paper

Radhakrishnan A, Pickup LC, Price AM, Law JP, McGee KC, Fabritz L, Senior R, Steeds RP, Ferro CJ, Townend JNet al., 2021, Coronary microvascular dysfunction is associated with degree of anaemia in end-stage renal disease, BMC CARDIOVASCULAR DISORDERS, Vol: 21, ISSN: 1471-2261

Journal article

Saeed S, Vamvakidou A, Zidros S, Papasozomenos G, Lysne V, Khattar RS, Senior Ret al., 2021, Sex differences in transaortic flow rate and association with all-cause mortality in patients with severe aortic stenosis, EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, Vol: 22, Pages: 977-982, ISSN: 2047-2404

Journal article

Bleakley C, Singh S, Garfield B, Morosin M, Surkova E, Mandalia MS, Dias B, Androulakis E, Price LC, McCabe C, Wort SJ, West C, Li W, Khattar R, Senior R, Patel BV, Price Set al., 2021, Right ventricular dysfunction in critically ill COVID-19 ARDS, International Journal of Cardiology, Vol: 327, Pages: 251-258, ISSN: 0167-5273

AIMS: Comprehensive echocardiography assessment of right ventricular (RV) impairment has not been reported in critically ill patients with COVID-19. We detail the specific phenotype and clinical associations of RV impairment in COVID-19 acute respiratory distress syndrome (ARDS). METHODS: Transthoracic echocardiography (TTE) measures of RV function were collected in critically unwell patients for associations with clinical, ventilatory and laboratory data. RESULTS: Ninety patients (25.6% female), mean age 52.0 ± 10.8 years, veno-venous extracorporeal membrane oxygenation (VVECMO) (42.2%) were studied. A significantly higher proportion of patients were identified as having RV dysfunction by RV fractional area change (FAC) (72.0%,95% confidence interval (CI) 61.0-81.0) and RV velocity time integral (VTI) (86.4%, 95 CI 77.3-93.2) than by tricuspid annular plane systolic excursion (TAPSE) (23.8%, 95 CI 16.0-33.9), RVS' (11.9%, 95% CI 6.6-20.5) or RV free wall strain (FWS) (35.3%, 95% CI 23.6-49.0). RV VTI correlated strongly with RV FAC (p ≤ 0.01). Multivariate regression demonstrated independent associations of RV FAC with NTpro-BNP and PVR. RV-PA coupling correlated with PVR (univariate p < 0.01), as well as RVEDAi (p < 0.01), and RVESAi (p < 0.01), and was associated with P/F ratio (p 0.026), PEEP (p 0.025), and ALT (p 0.028). CONCLUSIONS: Severe COVID-19 ARDS is associated with a specific phenotype of RV radial impairment with sparing of longitudinal function. Clinicians should avoid interpretation of RV health purely on long-axis parameters in these patients. RV-PA coupling potentially provides important additional information above standard measures of RV performance in this cohort.

Journal article

Lang NN, Ahmad FA, Cleland JG, O'Connor CM, Teerlink JR, Voors AA, Taubel J, Hodes AR, Anwar M, Karra R, Sakata Y, Ishihara S, Senior R, Khemka A, Prasad NG, DeSouza MM, Seiffert D, Ye JY, Kessler PD, Borentain M, Solomon SD, Felker GM, McMurray JJVet al., 2021, Haemodynamic effects of the nitroxyl donor cimlanod (BMS-986231) in chronic heart failure: a randomized trial, EUROPEAN JOURNAL OF HEART FAILURE, Vol: 23, Pages: 1147-1155, ISSN: 1388-9842

Journal article

Halliday B, Senior R, Pennell D, 2021, Assessing left ventricular systolic function – from ejection fraction to strain analysis, European Heart Journal, Vol: 42, Pages: 789-797, ISSN: 0195-668X

The measurement of left ventricular ejection fraction (LVEF) is a ubiquitous component of imaging studies used to evaluate patients with cardiac conditions and acts as an arbiter for many management decisions. This follows early trials investigating heart failure therapies which used a binary LVEF cut-off to select patients with the worst prognosis, who may gain the most benefit. Forty years on, the cardiac disease landscape has changed. LVEF is now a poor indicator of prognosis for many heart failure patients; specifically, for the half of patients with heart failure and truly preserved ejection fraction (HF-PEF). It is also recognised that LVEF may remain normal amongst patients with valvular heart disease who have significant myocardial dysfunction. This emphasises the importance of the interaction between LVEF and left ventricular geometry. Guidelines based on LVEF may therefore miss a proportion of patients who would benefit from early intervention to prevent further myocardial decompensation and future adverse outcomes. The assessment of myocardial strain, or intrinsic deformation, holds promise to improve these issues. The measurement of global longitudinal strain (GLS) has consistently been shown to improve the risk stratification of patients with heart failure and identify patients with valvular heart disease who have myocardial decompensation despite preserved LVEF and an increased risk of adverse outcomes. To complete the integration of GLS into routine clinical practice, further studies are required to confirm that such approaches improve therapy selection and accordingly, the outcome for patients.

Journal article

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