Publications
246 results found
Brown M, Black JRM, Sharma R, et al., 2016, Gene of the month: Axl, Journal of Clinical Pathology, Vol: 69, Pages: 391-397, ISSN: 0021-9746
The interaction between Axl receptor tyrosine kinase and its main ligand Gas6 has been implicated in the progression of a wide number of malignancies. More recently, overexpression of Axl has emerged as a key molecular determinant underlying the development of acquired resistance to targeted anticancer agents. The activation of Axl is overexpression-dependent and controls a number of hallmarks of cancer progression including proliferation, migration, resistance to apoptosis and survival through a complex network of intracellular second messengers. Axl has been noted to influence clinically meaningful end points including metastatic recurrence and survival in the vast majority of tumour types. With Axl inhibitors having gained momentum as novel anticancer therapies, we provide an overview of the biological and clinical relevance of this molecular pathway, outlining the main directions of research.
Howell J, Pinato D, Ramaswami R, et al., 2016, INTEGRATION OF THE CANCER-RELATED PRO-INFLAMMATORY RESPONSE AS A STRATIFYING BIOMARKER OF SURVIVAL BENEFIT WITH SORAFENIB IN HEPATOCELLULAR CARCINOMA, EASL International Liver Congress, Publisher: ELSEVIER SCIENCE BV, Pages: S195-S195, ISSN: 0168-8278
Dubash S, Keat N, Mapelli P, et al., 2016, Biodistribution and Radiation Dosimetry of a Novel 18F-Fluoroethyl Triazole [Tyr3] Octreotate Analogue for PET Imaging Patients with Advanced Neuroendocrine Tumours, 13th Annual ENETS Conference for the Diagnosis and Treatment of Neuroendocrine Tumor Disease, Publisher: KARGER, Pages: 58-58, ISSN: 0028-3835
Pinato DJ, Sharma R, Yen C, et al., 2016, THE ALBI GRADE PROVIDES OBJECTIVE HEPATIC RESERVE PHENOTYPING ACROSS EACH BCLC STAGE OF HEPATOCELLULAR CARCINOMA, EASL International Liver Congress, Publisher: ELSEVIER SCIENCE BV, Pages: S196-S196, ISSN: 0168-8278
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- Citations: 1
Sharma R, Kallur KG, Ryu JS, et al., 2015, Multicenter Reproducibility of <SUP>18</SUP>F-Fluciclatide PET Imaging in Subjects with Solid Tumors, JOURNAL OF NUCLEAR MEDICINE, Vol: 56, Pages: 1855-1861, ISSN: 0161-5505
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- Citations: 17
Mapelli P, Aboagye EO, Stebbing J, et al., 2015, Epigenetic changes in gastroenteropancreatic neuroendocrine tumours, ONCOGENE, Vol: 34, Pages: 4439-4447, ISSN: 0950-9232
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- Citations: 11
Pinato DJ, Sharma R, 2015, Liver Cancer, The SAGE Encyclopedia of Stem Cell Research, Publisher: SAGE Publications, ISBN: 9781506331898
This second edition reference work will serve as a universal resource for all public and academic libraries. It is an excellent foundation for anyone who is interested in the subject area of stem cell biology.
Ramaswami R, Pinato DJ, Kubota K, et al., 2015, Prognostic subclassification of Intermediate Hepatocellular Carcinoma (I-HCC): a multicentre cohort study with propensity score analysis, Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO) / Clinical Science Symposium on Predicting and Improving Adverse Outcomes in Older Adults with Cancer, Publisher: AMER SOC CLINICAL ONCOLOGY, ISSN: 0732-183X
Karali CS, Arino NM, Aboagye E, et al., 2015, Methylation of SSTR2 in gastroenteropancreatic tumours, Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO) / Clinical Science Symposium on Predicting and Improving Adverse Outcomes in Older Adults with Cancer, Publisher: AMER SOC CLINICAL ONCOLOGY, ISSN: 0732-183X
Pinato DJ, Trousil S, Caley M, et al., 2015, Pharmacological inhibition of Axl tyrosine kinase as a novel therapeutic strategy in hepatocellular carcinoma, Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO) / Clinical Science Symposium on Predicting and Improving Adverse Outcomes in Older Adults with Cancer, Publisher: AMER SOC CLINICAL ONCOLOGY, ISSN: 0732-183X
Pinato DJ, Karamanakos G, Ishizuka M, et al., 2015, The Kings Score refines prognostic prediction in hepatocellular carcinoma: a novel application, Liver International, Vol: 35, Pages: 2458-2465, ISSN: 1478-3223
Background & Aims: There are a number of prognostic scores in hepatocellular carcinoma (HCC), none of which is optimalin predicting overall survival (OS) in the individual patient, particularly in intermediate stage disease, where patients are notsurgically treatable but may qualify for a wide range of palliative interventions. We evaluated the prognostic role of a bio-chemical algorithm, the Kings Score (KS), in the palliative setting of care.Methods: We used the algorithm [age x AST xINR]/platelet count to derive the KS. Full clinical data including Barcelona Clinic Liver Cancer (BCLC) stage were studied in atraining set of 97 patients from the UK. Independent predictors of survival identified in multivariate analysis were validatedin an independent cohort of 766 patients from Japan and Italy.Results: In both training and validation sets, KS was con-firmed as an independent predictor of OS (P < 0.01). Ad-hoc subgroup analysis revealed the KS to be prognostic in the palli-ative setting, being able to subclassify patients presenting with intermediate and advanced disease according to BCLCcriteria (P < 0.001).Conclusion: The KS integrates into the BCLC system to improve prognostic substratification in the palli-ative setting of care. The KS may help reducing disease heterogeneity and refine treatment allocation in intermediate-advanced HCC.
Pinato DJ, Sharma R, 2015, Editorial: dynamic changes of the inflammation-based index predict mortality following chemoembolisation for hepatocellular carcinoma - authors' reply, Alimentary Pharmacology and Therapeutics, Vol: 41, Pages: 1218-1219, ISSN: 0269-2813
Challapalli A, Barwick T, Pearson RA, et al., 2015, 3′-Deoxy-3′-<SUP>18</SUP>F-fluorothymidine positron emission tomography as an early predictor of disease progression in patients with advanced and metastatic pancreatic cancer, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, Vol: 42, Pages: 831-840, ISSN: 1619-7070
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- Citations: 17
Pinato DJ, Arizumi T, Jang JW, et al., 2015, COMBINED SEQUENTIAL USE OF HAP AND ART SCORES TO PREDICT TRANSARTERIAL CHEMOEMBOLIZATION FAILURE IN HEPATOCELLULAR CARCINOMA: A MULTI-CENTER COMPARATIVE STUDY, 50th International Liver Congress of the European-Association-for-the-Study-of-the-Liver, Publisher: ELSEVIER SCIENCE BV, Pages: S456-S456, ISSN: 0168-8278
Smirne C, Grossi G, Pinato DJ, et al., 2015, Evaluation of the red cell distribution width as a biomarker of early mortality in hepatocellular carcinoma, Digestive and Liver Disease, Vol: 47, Pages: 488-494, ISSN: 1590-8658
Background: The red cell distribution width is a biomarker of early mortality across various disease states.Aim: To verify whether it may refine estimates of survival in hepatocellular carcinoma.Methods: The red cell distribution width measured at diagnosis was analyzed in relationship to mortalityby any cause both in a retrospective training cohort (N = 208), and in an independent prospectively collectedvalidation cohort (N = 106) of patients with hepatocellular carcinoma. Based on Cox proportionalhazards modelling, a prognostic index was validated.Results: In the training and the validation cohort, median survival time was respectively 1026 and 868days in patients with red cell distribution width ≤14.6%, vs. 282 and 340 days in patients with red celldistribution width >14.6%; the corresponding hazard ratios were 0.43 (95% CI: 0.31–0.60), p < 0.0001 and0.28 (95% CI: 0.17–0.47), p < 0.0001. At multivariate analysis, the red cell distribution width remained anindependent predictor of survival (p < 0.001) in a Cox model including other widely accepted prognosticfactors. Applying to the validation dataset the prognostic index derived from the training dataset,the ability of the model to discriminate the survival probabilities of patients was confirmed (Harrell’sC = 0.769).Conclusions: The red cell distribution width is a novel, reproducible, prospectively validated predictor ofsurvival in patients with hepatocellular carcinoma.
Ramachandran R, Bech P, Murphy KG, et al., 2015, Comparison of the Utility of Cocaine- and Amphetamine-Regulated Transcript (CART), Chromogranin A, and Chromogranin B in Neuroendocrine Tumor Diagnosis and Assessment of Disease Progression, Journal of Clinical Endocrinology & Metabolism, Vol: 100, Pages: 1520-1528, ISSN: 1945-7197
Wadhwani M, Bali SJ, Satyapal R, et al., 2015, Test-retest variability of retinal nerve fiber layer thickness and macular ganglion cell-inner plexiform layer thickness measurements using spectral-domain optical coherence tomography., J Glaucoma, Vol: 24, Pages: e109-e115
PURPOSE: To evaluate the test-retest variability of spectral-domain optical coherence tomography (OCT) in measurement of retinal nerve fiber layer (RNFL) thickness and macular ganglion cell-inner plexiform layer (GCIPL) thickness. METHODS: A total of 65 eyes of healthy subjects were enrolled in this observational cross-sectional study. RNFL thickness and GCIPL thickness were measured using the repeat scan optic cube and macular cube protocol using Cirrus HD-OCT (software version 6.0). A single operator obtained 3 measurements during 1 session to determine test-retest variability. Intrasession repeatability was defined by intraclass correlation, limits of agreement, and coefficient of variation. RESULTS: The mean age of patients was 37.89±15.11 years (range, 10 to 70 y). The mean RNFL thickness readings as measured during 3 sessions were 93.89±9.73, 93.63±10.00, and 93.55±9.64 μm and average GCIPL thickness measurements were 82.90±4.61, 82.98±4.24, and 83.06±4.36 μm, respectively. Coefficient of variation was 1.2 for average RNFL thickness and 0.82 for average GCIPL thickness. The intraclass correlation coefficient showed a good correlation between repeat measurements for both average RNFL and GCC thicknesses (0.994 and 0.990, respectively). The limits of agreement (95% confidence interval) for the 3 sessions ranged from -3.61 to 4.13 μm for the average RNFL thickness and -2.55 to 2.40 μm for GCIPL thickness measurements. CONCLUSIONS: In healthy eyes, Cirrus HD-OCT shows excellent intrasession repeatability for RNFL and GCIPL thickness measurements.
Sharma SK, Kohli M, Yadav RN, et al., 2015, Evaluating the Diagnostic Accuracy of Xpert MTB/RIF Assay in Pulmonary Tuberculosis., PLoS One, Vol: 10
Pulmonary tuberculosis still remains a major communicable disease worldwide. In 2013, 9 million people developed TB and 1.5 million people died from the disease. India constitutes 24% of the total TB burden. Early detection of TB cases is the key to successful treatment and reduction of disease transmission. Xpert MTB/RIF, an automated cartridge-based molecular technique detects Mycobacterium tuberculosis and rifampicin resistance within two hours has been endorsed by WHO for rapid diagnosis of TB. Our study is the first study from India with a large sample size to evaluate the performance of Xpert MTB/RIF assay in PTB samples. The test showed an overall sensitivity and specificity of 95.7% (430/449) and 99.3% (984/990) respectively. In smear negative-culture positive cases, the test had a sensitivity of 77.7%. The sensitivity and specificity for detecting rifampicin resistance was 94.5% and 97.7% respectively with respect to culture as reference standard. However, after resolving the discrepant samples with gene sequencing, the sensitivity and specificity rose to 99.0% and 99.3% respectively. Hence, while solid culture still forms the foundation of TB diagnosis, Xpert MTB/RIF proposes to be a strong first line diagnostic tool for pulmonary TB cases.
Pinato DJ, Arizumi T, Allara E, et al., 2014, Validation of the Hepatoma Arterial Embolization Prognostic Score in European and Asian Populations and Proposed Modification, Clinical Gastroenterology and Hepatology, Vol: 13, Pages: 1204-1208, ISSN: 1542-3565
Background & Aims: Transarterial chemoembolization (TACE) is used to treat hepatocellular carcinoma (HCC), but it is a challenge to predict patient survival. The hepatic arterial embolization prognostic (HAP) score has been shown to predict which patients will have shorter survival times and should not undergo TACE. We aimed to validate this scoring system in a prospective study of patients in Europe and Asia.Methods: We evaluated the prognostic accuracy of the HAP score in estimating overall survival (OS) of 126 patients with HCC who received TACE in the United Kingdom or Italy (training set) from 2001 through 2013. We also analyzed data from 723 patients treated in Korea and Japan (validation set), including 79 with newly diagnosed HCC, who underwent TACE in Korea or Japan from 2004 through 2013. Response to TACE was determined based on computed tomography analysis. OS was calculated from the time of the first TACE until death or the last follow-up evaluation.Results: OS was associated with hypoalbuminemia, α-fetoprotein level greater than 400 ng/mL, and tumor size greater than 7 cm at diagnosis (P < .01), but not a bilirubin level greater than 17 umol/L (P > .05), in both data sets. The lack of association between OS and bilirubin level was confirmed using receiver operating characteristic analysis. We developed a modified version of the HAP score, based on the level of albumin and α-fetoprotein and tumor size, which predicted OS with increased accuracy in the training and validation cohorts.Conclusions: In a multicenter validation study, we developed a modified version of the HAP that predicts survival of patients with HCC treated with TACE in Europe and Asia. This system might be used to identify patients with HCC most likely to benefit from TACE in clinical practice.
Trousil S, Lee P, Pinato DJ, et al., 2014, Alterations of choline phospholipid metabolism in endometrial cancer are caused by choline kinase alpha overexpression and a hyperactivated deacylation pathway, Cancer Research, Vol: 74, Pages: 6867-6877, ISSN: 0008-5472
Metabolic rearrangements subsequent to malignant transformation are not well characterized in endometrial cancer. Identification of altered metabolites could facilitate imaging-guided diagnosis, treatment surveillance, and help to identify new therapeutic options. Here, we used high-resolution magic angle spinning magnetic resonance mass spectroscopy on endometrial cancer surgical specimens and normal endometrial tissue to investigate the key modulators that might explain metabolic changes, incorporating additional investigations using qRT-PCR, Western blotting, tissue microarrays (TMA), and uptake assays of [3H]-labeled choline. Lipid metabolism was severely dysregulated in endometrial cancer with various amino acids, inositols, nucleobases, and glutathione also altered. Among the most important lipid-related alterations were increased phosphocholine levels (increased 70% in endometrial cancer). Mechanistic investigations revealed that changes were not due to altered choline transporter expression, but rather due to increased expression of choline kinase α (CHKA) and an activated deacylation pathway, as indicated by upregulated expression of the catabolic enzymes LYPLA1, LYPLA2, and GPCPD1. We confirmed the significance of CHKA overexpression on a TMA, including a large series of endometrial hyperplasia, atypical hyperplasia, and adenocarcinoma tissues, supporting a role for CHKA in malignant transformation. Finally, we documented several-fold increases in the uptake of [3H]choline in endometrial cancer cell lines compared with normal endometrial stromal cells. Our results validate deregulated choline biochemistry as an important source of noninvasive imaging biomarkers for endometrial cancer. Cancer Res; 74(23); 6867–77. ©2014 AACR.
Pinato DJ, Karamanakos G, Arizumi T, et al., 2014, Dynamic changes of the inflammation-based index predict mortality following chemoembolisation for hepatocellular carcinoma: a prospective study, ALIMENTARY PHARMACOLOGY & THERAPEUTICS, Vol: 40, Pages: 1270-1281, ISSN: 0269-2813
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- Citations: 27
Sharma SK, Kohli M, Chaubey J, et al., 2014, Evaluation of Xpert MTB/RIF assay performance in diagnosing extrapulmonary tuberculosis among adults in a tertiary care centre in India., Eur Respir J, Vol: 44, Pages: 1090-1093
Pinato DJ, Pirisi M, Maslen L, et al., 2014, Tissue Biomarkers of Prognostic Significance in Hepatocellular Carcinoma, ADVANCES IN ANATOMIC PATHOLOGY, Vol: 21, Pages: 270-284, ISSN: 1072-4109
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- Citations: 14
Mapelli P, Tam HH, Sharma R, et al., 2014, Frequency and significance of physiological versus pathological uptake of <SUP>68</SUP>Ga-DOTATATE in the pancreas: validation with morphological imaging, NUCLEAR MEDICINE COMMUNICATIONS, Vol: 35, Pages: 613-619, ISSN: 0143-3636
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- Citations: 16
Pinato DJ, Ishizuka M, Karamanakos G, et al., 2014, The London Liver Cancer Score (LLCS): A novel and validated prognostic algorithm in hepatocellular carcinoma., 50th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Publisher: LIPPINCOTT WILLIAMS & WILKINS, ISSN: 0732-183X
Mapelli P, Tam H, Sharma R, et al., 2014, Physiological uptake of 68Ga-DOTATATE in the pancreas: Does it matter?, Annual Meeting of the Society-of-Nuclear-Medicine-and-Molecular-Imaging (SNMMI), Publisher: SOC NUCLEAR MEDICINE INC, ISSN: 0161-5505
Mapelli P, Tam H, Sharma R, et al., 2014, Physiological uptake of 68Ga-DOTATATE in the pancreas: Does it matter?, Annual Meeting of the Society-of-Nuclear-Medicine-and-Molecular-Imaging (SNMMI), Publisher: SOC NUCLEAR MEDICINE INC, ISSN: 0161-5505
Pinato DJ, Shiner RJ, Seckl MJ, et al., 2014, Prognostic performance of inflammation-based prognostic indices in primary operable non-small cell lung cancer, BRITISH JOURNAL OF CANCER, Vol: 110, Pages: 1930-1935, ISSN: 0007-0920
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- Citations: 124
Rosmarin D, Palles C, Church D, et al., 2014, Genetic Markers of Toxicity From Capecitabine and Other Fluorouracil-Based Regimens: Investigation in the QUASAR2 Study, Systematic Review, and Meta-Analysis, JOURNAL OF CLINICAL ONCOLOGY, Vol: 32, Pages: 1031-1039, ISSN: 0732-183X
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- Citations: 175
Pinato DJ, Karamanakos G, Goyal A, et al., 2014, DYNAMIC CHANGES OF THE INFLAMMATION BASED INDEX (IBI) AS A PREDICTOR OF MORTALITY FOLLOWING TRANS-ARTERIAL CHEMOEMBOLIZATION FOR HEPATOCELLULAR CARCINOMA, 49th Annual International Liver Congress of the European-Association-for-the-Study-of-the-Liver, Publisher: ELSEVIER SCIENCE BV, Pages: S400-S400, ISSN: 0168-8278
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