Publications
246 results found
Challapalli A, Sharma R, Hallett WA, et al., 2014, Biodistribution and Radiation Dosimetry of Deuterium-Substituted <SUP>18</SUP>F-Fluoromethyl-[1, 2-<SUP>2</SUP>H<sub>4</sub>]Choline in Healthy Volunteers, JOURNAL OF NUCLEAR MEDICINE, Vol: 55, Pages: 256-263, ISSN: 0161-5505
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- Citations: 21
Mohamed Z, Pinato DJ, Mauri FA, et al., 2014, Inflammation as a validated prognostic determinant in carcinoma of unknown primary site, BRITISH JOURNAL OF CANCER, Vol: 110, Pages: 208-213, ISSN: 0007-0920
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- Citations: 19
Bhanot A, Sharma R, Singh S, et al., 2013, In vitro anti cancer activity of ethanol extract fractions of Aerva lanata L., Pak J Biol Sci, Vol: 16, Pages: 1612-1617, ISSN: 1028-8880
To explore in vitro anticancer potential of Aerva lanata L. (flowering aerial part). The study was performed with 5 different human cell lines for the study of lung, leukaemia, prostate, colon and cervix cancer by using Sulphorhodamine B (SRB) assay. There were three doses of 10, 30 and 100 microg mL(-1) of each Aerva lanata L. Chloroform fraction (ALCF) and Aerva lanata L. Ethyl Acetate Fraction (ALEAF) used in this study. ALCF showed significant % inhibitory effect for leukaemia, lung and colon cancer at maximum concentration of 100 microg mL(-1) as compared to standard drug mitomycin. On the other hand ALEAF showed the significant % inhibitory effect for lung and cervix cancer at maximum concentration of 100 microg mL(-1) as compared to standard drug 5-fluoro Uracil (5-FU). From the above studies it is concluded that, the ethyl acetate fraction and chloroform fraction of Aerva lanata L. provide enough experimental evidence for anticancer activity and these fractions could be useful in medical care.
Pinato DJ, Tan TM, Toloue S, et al., 2013, An expression signature of the angiogenic response in gastrointestinal neuroendocrine tumours: correlation with tumour phenotype and survival outcomes., British Journal of Cancer, Vol: 110, ISSN: 1532-1827
Mapelli P, Tam HH, Portigliotti L, et al., 2013, The perplexing pancreas: when is pancreatic 68Ga DOTATATE uptake suspicious?, Annual Congress of the European-Association-of-Nuclear-Medicine (EANM), Publisher: SPRINGER, Pages: S253-S253, ISSN: 1619-7070
Kacevska M, Mahns A, Sharma R, et al., 2013, Extra-Hepatic Cancer Represses Hepatic Drug Metabolism <i>Via</i> Interleukin (IL)-6 Signalling, PHARMACEUTICAL RESEARCH, Vol: 30, Pages: 2270-2278, ISSN: 0724-8741
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- Citations: 11
Pinato DJ, Sharma R, 2013, Imatinib induced pyoderma gangrenosum, JOURNAL OF POSTGRADUATE MEDICINE, Vol: 59, Pages: 244-245, ISSN: 0022-3859
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- Citations: 10
Pinato DJ, Tan TM, Toloue-Kalami-Toussi S, et al., 2013, AN EXPRESSION SIGNATURE OF THE ANGIOGENIC RESPONSE IN GASTROINTESTINAL NEUROENDOCRINE TUMOURS: CORRELATION WITH TUMOUR PHENOTYPE AND SURVIVAL OUTCOMES, Annual General Meeting of the British-Society-of-Gastroenterology, Publisher: BMJ PUBLISHING GROUP, Pages: A29-A29, ISSN: 0017-5749
Adjogatse DA, Karamanakos G, Pinato DJ, et al., 2013, The inflammation based index (IBI) predicts survival advantage after transarterial chemoembolization in hepatocellular carcinoma., ASCO Annual Meeting 2013
Pinato DJ, Graham J, Gabra H, et al., 2013, Evolving concepts in the management of drug resistant ovarian cancer: Dose dense chemotherapy and the reversal of clinical platinum resistance, CANCER TREATMENT REVIEWS, Vol: 39, Pages: 153-160, ISSN: 0305-7372
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- Citations: 49
Pinato DJ, Nya P, Sharma R, et al., 2013, CD24: a potential new marker in differentiating malignant mesothelioma from pulmonary adenocarcinoma, JOURNAL OF CLINICAL PATHOLOGY, Vol: 66, Pages: 256-259, ISSN: 0021-9746
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- Citations: 3
Pinato DJ, Mauri FA, Lloyd T, et al., 2013, The expression of Axl receptor tyrosine kinase influences the tumour phenotype and clinical outcome of patients with malignant pleural mesothelioma, BRITISH JOURNAL OF CANCER, Vol: 108, Pages: 621-628, ISSN: 0007-0920
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- Citations: 28
Pinato DJ, Ramachandran R, Toussi STK, et al., 2013, Immunohistochemical markers of the hypoxic response can identify malignancy in phaeochromocytomas and paragangliomas and optimize the detection of tumours with VHL germline mutations, BRITISH JOURNAL OF CANCER, Vol: 108, Pages: 429-437, ISSN: 0007-0920
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- Citations: 34
Yadav RN, Singh BK, Sharma SK, et al., 2013, Comparative evaluation of GenoType MTBDRplus line probe assay with solid culture method in early diagnosis of multidrug resistant tuberculosis (MDR-TB) at a tertiary care centre in India., PLoS One, Vol: 8
BACKGROUND: The objectives of the study were to compare the performance of line probe assay (GenoType MTBDRplus) with solid culture method for an early diagnosis of multidrug resistant tuberculosis (MDR-TB), and to study the mutation patterns associated with rpoB, katG and inhA genes at a tertiary care centre in north India. METHODS: In this cross-sectional study, 269 previously treated sputum-smear acid-fast bacilli (AFB) positive MDR-TB suspects were enrolled from January to September 2012 at the All India Institute of Medical Sciences hospital, New Delhi. Line probe assay (LPA) was performed directly on the sputum specimens and the results were compared with that of conventional drug susceptibility testing (DST) on solid media [Lowenstein Jensen (LJ) method]. RESULTS: DST results by LPA and LJ methods were compared in 242 MDR-TB suspects. The LPA detected rifampicin (RIF) resistance in 70 of 71 cases, isoniazid (INH) resistance in 86 of 93 cases, and MDR-TB in 66 of 68 cases as compared to the conventional method. Overall (rifampicin, isoniazid and MDR-TB) concordance of the LPA with the conventional DST was 96%. Sensitivity and specificity were 98% and 99% respectively for detection of RIF resistance; 92% and 99% respectively for detection of INH resistance; 97% and 100% respectively for detection of MDR-TB. Frequencies of katG gene, inhA gene and combined katG and inhA gene mutations conferring all INH resistance were 72/87 (83%), 10/87 (11%) and 5/87 (6%) respectively. The turnaround time of the LPA test was 48 hours. CONCLUSION: The LPA test provides an early diagnosis of monoresistance to isoniazid and rifampicin and is highly sensitive and specific for an early diagnosis of MDR-TB. Based on these findings, it is concluded that the LPA test can be useful in early diagnosis of drug resistant TB in high TB burden countries.
Sharma R, Kallur KG, Ryu JS, et al., 2012, Test-retest reproducibility of [<SUP>18</SUP>F]fluciclatide PET imaging in subjects with solid tumors, 25th Annual Congress of the European-Association-of-Nuclear-Medicine (EANM), Publisher: SPRINGER, Pages: S226-S226, ISSN: 1619-7070
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- Citations: 1
Mohamed Z, Pinato DJ, Sharma R, 2012, NOVEL INFLAMMATION-BASED PROGNOSTIC DETERMINANTS IN PATIENTS WITH CARCINOMA OF UNKNOWN PRIMARY, 37th Congress of the European-Society-for-Medical-Oncology (ESMO), Publisher: OXFORD UNIV PRESS, Pages: 381-381, ISSN: 0923-7534
Pinato DJ, Sharma R, 2012, An inflammation-based prognostic index predicts survival advantage after transarterial chemoembolization in hepatocellular carcinoma, TRANSLATIONAL RESEARCH, Vol: 160, Pages: 146-152, ISSN: 1931-5244
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- Citations: 56
Mauri FA, Pinato DJ, Trivedi P, et al., 2012, Isogeneic comparison of primary and metastatic lung cancer identifies CX3CR1 as a molecular determinant of site-specific metastatic diffusion, ONCOLOGY REPORTS, Vol: 28, Pages: 647-653, ISSN: 1021-335X
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- Citations: 10
Pinato DJ, Stebbing J, Ishizuka M, et al., 2012, A novel and validated prognostic index in hepatocellular carcinoma: The inflammation based index (IBI), Publisher: Elsevier, Pages: 1013-1020, ISSN: 1600-0641
Background & AimsOutcome prediction is uniquely different in hepatocellular carcinoma (HCC) as the progressive functional impairment of the liver impacts patient survival independently of tumour stage. As chronic inflammation is associated with the pathogenesis of HCC, we explored the prognostic impact of a panel of inflammatory based scores, including the modified Glasgow Prognostic Score (mGPS), neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR), in independent cohorts.MethodsInflammatory markers, Barcelona Clinic Liver Cancer (BCLC) and Cancer of the Liver Italian Program (CLIP) scores were studied in a training set of 112 patients with predominantly unresectable HCC (75%). Independent predictors of survival identified in multivariate analysis were validated in an independent cohort of 466 patients with an overall lower tumour burden (BCLC-A, 56%).ResultsIn both training and validation sets, mGPS and CLIP scores emerged as independent predictors of overall survival. The predictive accuracy of the combined mGPS and CLIP score (c score 0.7, 95% CI 0.6–0.8) appeared superior to that of the CLIP score alone (c score 0.6, 95% CI 0.5–0.7).ConclusionsSystemic inflammation as measured by the mGPS, independently predicts overall survival in HCC. We have validated a novel, easy to use inflammatory score that can be used to stratify individuals. These data enable formulation of a new prognostic system, the inflammation based index in HCC (IBI). Further validation of the IBI considering treatment allocation and survival is warranted in an independent patient cohort.
Contractor K, Challapalli A, Tomasi G, et al., 2012, Imaging of cellular proliferation in liver metastasis by [<SUP>18</SUP>F]fluorothymidine positron emission tomography: effect of therapy, PHYSICS IN MEDICINE AND BIOLOGY, Vol: 57, Pages: 3419-3433, ISSN: 0031-9155
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- Citations: 16
Challapalli A, Wasan HS, Al-Nahhas A, et al., 2012, <SUP>18</SUP>F-fluorothymidine (FLT) PET-CT for early response assessment in advanced pancreatic cancer, 48th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Publisher: AMER SOC CLINICAL ONCOLOGY, ISSN: 0732-183X
Pinato DJ, North BV, Sharma R, 2012, A novel, externally validated inflammation-based prognostic algorithm in hepatocellular carcinoma: the prognostic nutritional index (PNI), BRITISH JOURNAL OF CANCER, Vol: 106, Pages: 1439-1445, ISSN: 0007-0920
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- Citations: 303
Pinato DJ, Stebbing J, Ishizuka M, et al., 2012, A novel and validated prognostic index in hepatocellular carcinoma: the Inflammation Based Index (IBI)., EASL International Liver Meeting
Pinato DJ, Mauri FA, Ramakrishnan R, et al., 2012, Inflammation-Based Prognostic Indices in Malignant Pleural Mesothelioma, JOURNAL OF THORACIC ONCOLOGY, Vol: 7, Pages: 587-594, ISSN: 1556-0864
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- Citations: 115
Healey CS, Ahmed S, ANECS, et al., 2011, Breast cancer susceptibility polymorphisms and endometrial cancer risk: a Collaborative Endometrial Cancer Study., Carcinogenesis, Vol: 32, Pages: 1862-1866
Recent large--scale association studies, both of genome-wide and candidate gene design, have revealed several single-nucleotide polymorphisms (SNPs) which are significantly associated with risk of developing breast cancer. As both breast and endometrial cancers are considered to be hormonally driven and share multiple risk factors, we investigated whether breast cancer risk alleles are also associated with endometrial cancer risk. We genotyped nine breast cancer risk SNPs in up to 4188 endometrial cases and 11,928 controls, from between three and seven Caucasian populations. None of the tested SNPs showed significant evidence of association with risk of endometrial cancer.
Pinato DJ, Krell J, Wasan H, et al., 2011, Neoplastic infiltration of the sphenoid wing: A rare manifestation of metastatic colorectal cancer, ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, Vol: 7, Pages: 399-400, ISSN: 1743-7555
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- Citations: 5
Sharma R, Aboagye E, 2011, Development of radiotracers for oncology - the interface with pharmacology, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 163, Pages: 1565-1585, ISSN: 0007-1188
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- Citations: 38
Sharma R, Graham J, Blagden S, et al., 2011, Sustained platelet-sparing effect of weekly low dose paclitaxel allows effective, tolerable delivery of extended dose dense weekly carboplatin in platinum resistant/refractory epithelial ovarian cancer, BMC Cancer, Vol: 11, ISSN: 1471-2407
BackgroundPlatinum agents have shown demonstrable activity in the treatment of patients with platinum resistant, recurrent ovarian cancer when delivered in a "dose-dense" fashion. However, the development of thrombocytopenia limits the weekly administration of carboplatin to no greater than AUC 2. Paclitaxel has a well-described platelet sparing effect however its use to explicitly provide thromboprotection in the context of dose dense carboplatin has not been explored.MethodsWe treated seven patients with platinum resistant ovarian cancer who had previously received paclitaxel or who had developed significant peripheral neuropathy precluding the use of further full dose weekly paclitaxel.ResultsWe were able to deliver carboplatin AUC 3 and paclitaxel 20 mg/m2 with no thrombocytopenia or worsening of neuropathic side-effects, and with good activity.ConclusionsWe conclude that this regimen may be feasible and active, and could be formally developed as a "platinum-focussed dose-dense scaffold" into which targeted therapies that reverse platinum resistance can be incorporated, and merits further evaluation.
Arya V, Sharma R, Parmar RK, 2011, A newer approach in purification of acetone extract of Pyrus pashia Buch.-Ham. ex D. Don stem bark, International Journal of Pharmaceutical Sciences Review and Research, Vol: 9, Pages: 142-146
This study reported the purification of acetone extract of Pyrus pashia Buch.-Ham. ex D. Don stem bark. The powdered drug was defatted with petroleum ether and then extracted with acetone. The orange brown acetone extract had no odour, showed the presence of desired phytochemicals i.e. steroids, tannins, terpenes etc. The acetone extract was further subjected to chromatographic purification in separating funnel and one pure compound has been successfully isolated from acetone fraction which was confirmed on the basis of TLC, paper chromatography. UV spectroscopic studies were also performed on isolated compound. This method of purification involving separating funnel was employed for the first time and found to be simple, cost effective and highly efficient for purification of acetone extract of Pyrus pashia Buch.-Ham. ex D. Don stem bark.
Kacevska M, Downes MR, Sharma R, et al., 2011, Extrahepatic Cancer Suppresses Nuclear Receptor-Regulated Drug Metabolism, CLINICAL CANCER RESEARCH, Vol: 17, Pages: 3170-3180, ISSN: 1078-0432
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- Citations: 28
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