Imperial College London
Alternate

ProfessorRobinShattock

Faculty of Medicine, Department of Infectious Disease

Chair in Mucosal Infection and Immunity
 
 
 
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Contact

 

+44 (0)20 7594 5206r.shattock

 
 
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Location

 

453Wright Fleming WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{McKay:2019:10.7554/eLife.46149,
author = {McKay, P and Cizmeci, D and Aldon, Y and Maertzdorf, J and Weiner, J and Kaufmann, S and Lewis, D and van, den Berg R and Del, Giudice G and Shattock, R},
doi = {10.7554/eLife.46149},
journal = {eLife},
title = {Identification of potential biomarkers of vaccine inflammation in mice},
url = {http://dx.doi.org/10.7554/eLife.46149},
volume = {8},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Systems vaccinology approaches have been used successfully to define early signatures of the vaccine-induced immune response. However, the possibility that transcriptomics can also identify a correlate or surrogate for vaccine inflammation has not been fully explored. We have compared four licensed vaccines with known safety profiles, as well as three agonists of Toll-like receptors (TLRs) with known inflammatory potential, to elucidate the transcriptomic profile of an acceptable response to vaccination versus that of an inflammatory reaction. In mice, we looked at the transcriptomic changes in muscle at the injection site, the lymph node that drained the muscle, and the peripheral blood mononuclear cells (PBMCs)isolated from the circulating blood from 4 hr after injection and over the next week. A detailed examination and comparative analysis of these transcriptomes revealed a set of novel biomarkers that are reflective of inflammation after vaccination. These biomarkers are readily measurable in the peripheral blood, providing useful surrogates of inflammation, and provide a way to select candidates with acceptable safety profiles.
AU  - McKay,P
AU  - Cizmeci,D
AU  - Aldon,Y
AU  - Maertzdorf,J
AU  - Weiner,J
AU  - Kaufmann,S
AU  - Lewis,D
AU  - van,den Berg R
AU  - Del,Giudice G
AU  - Shattock,R
DO  - 10.7554/eLife.46149
PY  - 2019///
SN  - 2050-084X
TI  - Identification of potential biomarkers of vaccine inflammation in mice
T2  - eLife
UR  - http://dx.doi.org/10.7554/eLife.46149
UR  - http://hdl.handle.net/10044/1/70552
VL  - 8
ER  -
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