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@article{Horvath:2023:10.3389/fimmu.2022.1075606,
author = {Horvath, A and Rogers, L and Pollakis, G and Baranov, O and Pieroth, N and Joseph, S and Chachage, M and Heitzer, A and Maganga, L and Msafiri, F and Joachim, A and Viegas, E and Eller, L-A and Kibuuka, H and Rerks-Ngarm, S and Pitisuttithum, P and Nitayapan, S and Dhitavat, J and Premsri, N and Fidler, S and Shattock, RJJ and Robb, ML and Weber, J and McCormack, S and Munseri, PJ and Lyamuya, E and Nilsson, C and Kroidl, A and Hoelscher, M and Wagner, R and Geldmacher, C and Held, K},
doi = {10.3389/fimmu.2022.1075606},
journal = {Frontiers in Immunology},
pages = {1--16},
title = {Systematic comparison of HIV-1 Envelope-specific IgG responses induced by different vaccination regimens: Can we steer IgG recognition towards regions of viral vulnerability?},
url = {http://dx.doi.org/10.3389/fimmu.2022.1075606},
volume = {13},
year = {2023}
}

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TY  - JOUR
AB  - Immunogens and vaccination regimens can influence patterns of immune-epitope recognition, steering them towards or away from epitopes of potential viral vulnerability. HIV-1 envelope (Env)-specific antibodies targeting variable region 2 (V2) or 3 (V3) correlated with protection during the RV144 trial, however, it was suggested that the immunodominant V3 region might divert antibody responses away from other relevant sites. We mapped IgG responses against linear Env epitopes in five clinical HIV vaccine trials, revealing a specific pattern of Env targeting for each regimen. Notable V2 responses were only induced in trials administering CRF01_AE based immunogens, but targeting of V3 was seen in all trials, with the soluble, trimeric CN54gp140 protein eliciting robust V3 recognition. Strong V3 targeting was linked to greater overall response, increased number of total recognised antigenic regions, and where present, stronger V2 recognition. Hence, strong induction of V3-specific antibodies did not negatively impact the targeting of other linear epitopes in this study, suggesting that the induction of antibodies against V3 and other regions of potential viral vulnerability need not be necessarily mutually exclusive.
AU  - Horvath,A
AU  - Rogers,L
AU  - Pollakis,G
AU  - Baranov,O
AU  - Pieroth,N
AU  - Joseph,S
AU  - Chachage,M
AU  - Heitzer,A
AU  - Maganga,L
AU  - Msafiri,F
AU  - Joachim,A
AU  - Viegas,E
AU  - Eller,L-A
AU  - Kibuuka,H
AU  - Rerks-Ngarm,S
AU  - Pitisuttithum,P
AU  - Nitayapan,S
AU  - Dhitavat,J
AU  - Premsri,N
AU  - Fidler,S
AU  - Shattock,RJJ
AU  - Robb,ML
AU  - Weber,J
AU  - McCormack,S
AU  - Munseri,PJ
AU  - Lyamuya,E
AU  - Nilsson,C
AU  - Kroidl,A
AU  - Hoelscher,M
AU  - Wagner,R
AU  - Geldmacher,C
AU  - Held,K
DO  - 10.3389/fimmu.2022.1075606
EP  - 16
PY  - 2023///
SN  - 1664-3224
SP  - 1
TI  - Systematic comparison of HIV-1 Envelope-specific IgG responses induced by different vaccination regimens: Can we steer IgG recognition towards regions of viral vulnerability?
T2  - Frontiers in Immunology
UR  - http://dx.doi.org/10.3389/fimmu.2022.1075606
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000920274200001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR  - https://www.frontiersin.org/articles/10.3389/fimmu.2022.1075606/full
UR  - http://hdl.handle.net/10044/1/102257
VL  - 13
ER  -

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