Imperial College London
Dr Romain Silhol

DrRomainSilhol

Faculty of Medicine, School of Public Health

Research Fellow
 
 
 
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Contact

 

r.silhol

 
 
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Location

 

School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Obadia:2015:10.1371/journal.pcbi.1004170,
author = {Obadia, T and Silhol, R and Opatowski, L and Temime, L and Legrand, J and Thiebaut, ACM and Herrmann, J-L and Fleury, E and Guillemot, D and Boelle, P-Y},
doi = {10.1371/journal.pcbi.1004170},
journal = {PLoS Computational Biology},
pages = {1--16},
title = {Detailed contact data and the dissemination of staphylococcus aureus in hospitals},
url = {http://dx.doi.org/10.1371/journal.pcbi.1004170},
volume = {11},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Close proximity interactions (CPIs) measured by wireless electronic devices are increasingly used in epidemiological models. However, no evidence supports that electronically collected CPIs inform on the contacts leading to transmission. Here, we analyzed Staphylococcus aureus carriage and CPIs recorded simultaneously in a long-term care facility for 4 months in 329 patients and 261 healthcare workers to test this hypothesis. In the broad diversity of isolated S. aureus strains, 173 transmission events were observed between participants. The joint analysis of carriage and CPIs showed that CPI paths linking incident cases to other individuals carrying the same strain (i.e. possible infectors) had fewer intermediaries than predicted by chance (P < 0.001), a feature that simulations showed to be the signature of transmission along CPIs. Additional analyses revealed a higher dissemination risk between patients via healthcare workers than via other patients. In conclusion, S. aureus transmission was consistent with contacts defined by electronically collected CPIs, illustrating their potential as a tool to control hospital-acquired infections and help direct surveillance.
AU  - Obadia,T
AU  - Silhol,R
AU  - Opatowski,L
AU  - Temime,L
AU  - Legrand,J
AU  - Thiebaut,ACM
AU  - Herrmann,J-L
AU  - Fleury,E
AU  - Guillemot,D
AU  - Boelle,P-Y
DO  - 10.1371/journal.pcbi.1004170
EP  - 16
PY  - 2015///
SN  - 1553-734X
SP  - 1
TI  - Detailed contact data and the dissemination of staphylococcus aureus in hospitals
T2  - PLoS Computational Biology
UR  - http://dx.doi.org/10.1371/journal.pcbi.1004170
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000352195700048&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1004170
UR  - http://hdl.handle.net/10044/1/84159
VL  - 11
ER  -
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