Imperial College London
Alternate

Emeritus ProfessorRobertSinden

Faculty of Natural Sciences, Department of Life Sciences

Emeritus Professor of Parasite Cell Biology
 
 
 
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Contact

 

r.sinden Website

 
 
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Location

 

2.1Centre for Population BiologySilwood Park

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Summary

 

Publications

Publication Type
Year
to

381 results found

Yoshida S, Matsuoka H, Luo EJ, Iwai K, Arai M, Sinden RE, Ishii Aet al., 1999, A single-chain antibody fragment specific for the <i>Plasmodium berghei</i> ookinete protein Pbs21 confers transmission blockade in the mosquito midgut, MOLECULAR AND BIOCHEMICAL PARASITOLOGY, Vol: 104, Pages: 195-204, ISSN: 0166-6851

Journal article

Dessens JT, Beetsma AL, Dimopoulos G, Wengelnik K, Crisanti A, Kafatos FC, Sinden REet al., 1999, CTRP is essential for mosquito infection by malaria ookinetes, EMBO JOURNAL, Vol: 18, Pages: 6221-6227, ISSN: 0261-4189

Journal article

Blanco ARA, Paez A, Gerold P, Dearsly AL, Margos G, Schwarz RT, Barker G, Rodriguez MC, Sinden REet al., 1999, The biosynthesis and post-translational modification of Pbs21 an ookinete-surface protein of <i>Plasmodium berghei</i>, MOLECULAR AND BIOCHEMICAL PARASITOLOGY, Vol: 98, Pages: 163-173, ISSN: 0166-6851

Journal article

Thompson J, van Spaendonk RML, Choudhuri R, Sinden RE, Janse CJ, Waters APet al., 1999, Heterogeneous ribosome populations are present in <i>Plasmodium berghei</i> during development in its vector, MOLECULAR MICROBIOLOGY, Vol: 31, Pages: 253-260, ISSN: 0950-382X

Journal article

Crampton JM, Stowell SL, Karras M, Sinden REet al., 1999, Model systems to evaluate the use of transgenic haematophagous insects to deliver protective Vaccines, PARASSITOLOGIA, VOL 41, NOS 1-3, SEPTEMBER 1999, Pages: 473-477

Journal article

Sinden RE, 1999, <i>Plasmodium</i> differentiation in the mosquito, PARASSITOLOGIA, VOL 41, NOS 1-3, SEPTEMBER 1999, Pages: 139-148

Journal article

Plebanski M, Gilbert SC, Schneider J, Hannan CM, Layton G, Blanchard T, Becker M, Smith G, Butcher G, Sinden RE, Hill AVSet al., 1998, Protection from <i>Plasmodium berghei</i> infection by priming and boosting T cells to a single class I-restricted epitope with recombinant carriers suitable for human use, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 28, Pages: 4345-4355, ISSN: 0014-2980

Journal article

Margos G, van Dijk MR, Ramesar J, Janse CJ, Waters AP, Sinden REet al., 1998, Transgenic expression of a mosquito-stage malarial protein, Pbs21, in blood stages of transformed <i>Plasmodium berghei</i> and induction of an immune response upon infection, INFECTION AND IMMUNITY, Vol: 66, Pages: 3884-3891, ISSN: 0019-9567

Journal article

Navarrete S, Butcher GA, Margos G, Davies A, Willers C, Lachmann PJ, Sinden REet al., 1998, Interactions between complement and the malaria parasite in the mosquito gut, MOLECULAR IMMUNOLOGY, Vol: 35, Pages: 340-340, ISSN: 0161-5890

Journal article

Schneider J, Gilbert SC, Blanchard TJ, Hanke T, Robson KJ, Hannan CM, Becker M, Sinden R, Smith GL, Hill AVSet al., 1998, Enhanced immunogenicity for CD8+ T cell induction and complete protective efficacy of malaria DNA vaccination by boosting with modified vaccinia virus Ankara, NATURE MEDICINE, Vol: 4, Pages: 397-402, ISSN: 1078-8956

Journal article

Billker O, Lindo V, Panico M, Etienne AE, Paxton T, Dell A, Rogers M, Sinden RE, Morris HRet al., 1998, Identification of xanthurenic acid as the putative inducer of malaria development in the mosquito, NATURE, Vol: 392, Pages: 289-292, ISSN: 0028-0836

Journal article

Charlwood JD, Mendis C, Thompson R, Begtrup K, Cuamba N, Dgedge M, Gamage-Mendis A, Hunt RH, Sinden RE, Hogh Bet al., 1998, Cordon Sanitaire or Laissez Faire:: differential dispersal of young and old females of the malaria vector Anopheles funestus Giles (Diptera: Culicidae) in southern Mozambique, AFRICAN ENTOMOLOGY, Vol: 6, Pages: 1-6, ISSN: 1021-3589

Journal article

Sinden RE, 1998, Malaria transfection: A new tool to study molecular function, PARASITOLOGY TODAY, Vol: 14, Pages: 88-90, ISSN: 0169-4758

Journal article

Hogh B, Gamage-Mendis A, Butcher GA, Thompson R, Begtrup K, Mendis C, Enosse SM, Dgedge M, Barreto J, Eling W, Sinden REet al., 1998, The differing impact of chloroquine and pyrimethamine/sulfadoxine upon the infectivity of malaria species to the mosquito vector, AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, Vol: 58, Pages: 176-182, ISSN: 0002-9637

Journal article

Crampton JM, Stowell S, Karras M, Sinden REet al., 1998, Genetic manipulation of mosquito disease vectors: incompetent mosquitoes and vaccine deliverers, 9th International Congress of Parasitology (ICOPA IX), Publisher: MEDIMOND S R L, Pages: 111-115

Conference paper

Thompson R, Begtrup K, Cuamba N, Dgedge M, Mendis C, GamageMendis A, Enosse SM, Barreto J, Sinden RE, Hogh Bet al., 1997, The Matola malaria project: A temporal and spatial study of malaria transmission and disease in a suburban area of Maputo, Mozambique, AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, Vol: 57, Pages: 550-559, ISSN: 0002-9637

Journal article

vanPelt JF, Butcher G, Hollingdale MR, Verhave JP, Sinden RE, Yap SHet al., 1997, Differences in susceptibility of human hepatocytes to the invasion of Plasmodium falciparum sporozoites in vitro is associated with the development stage of the hepatocytes., HEPATOLOGY, Vol: 26, Pages: 263-263, ISSN: 0270-9139

Journal article

Billingsley PF, Sinden RE, 1997, Determinants of malaria-mosquito specificity, PARASITOLOGY TODAY, Vol: 13, Pages: 297-301, ISSN: 0169-4758

Journal article

Billker O, Shaw MK, Margos G, Sinden REet al., 1997, The roles of temperature, pH and mosquito factors as triggers of male and female gametogenesis of Plasmodium berghei in vitro, PARASITOLOGY, Vol: 115, Pages: 1-7, ISSN: 0031-1820

Journal article

Sinden RE, 1997, Antimalarial transmission-blocking vaccines, 5th CEC Malaria Contract Holders Meeting, Publisher: MANEY PUBLISHING, Pages: S69-S84, ISSN: 0003-4983

Conference paper

Robson KJH, Naitza S, Barker G, Sinden RE, Crisanti Aet al., 1997, Cloning and expression of the thrombospondin related adhesive protein gene of Plasmodium berghei, MOLECULAR AND BIOCHEMICAL PARASITOLOGY, Vol: 84, Pages: 1-12, ISSN: 0166-6851

Journal article

Butcher GA, Sinden RE, Billker O, 1996, Plasmodium berghei: Infectivity of mice to Anopheles stephensi mosquitoes, EXPERIMENTAL PARASITOLOGY, Vol: 84, Pages: 371-379, ISSN: 0014-4894

Journal article

Spano F, Matsuoka H, Ozawa R, Chinzei Y, Sinden REet al., 1996, Epitope mapping on the ookinete surface antigen Pbs21 of Plasmodium berghei: identification of the site of binding of transmission-blocking monoclonal antibody 13.1., Parassitologia, Vol: 38, Pages: 559-563, ISSN: 0048-2951

The ookinete surface protein of Plasmodium berghei Pbs21 belongs to a class of sexual stage antigens able to induce in the vertebrate host a transmission-blocking immune response. The effectors of this transmission-blocking immunity are antibody molecules directed against particular protein epitopes. The anti-Pbs21 monoclonal antibody 13.1 is known to bind a linear stretch of amino acids within the primary sequence of Pbs21 and to efficiently block the development of P. berghei in the mosquito gut. To map the 13.1 epitope along the amino acid sequence of Pbs21 we assayed the ability of 13.1 antibody to recognize, in Western blot, a series of Pbs21 deletion mutants as well as the ability of synthetic peptides to inhibit 13.1 binding to full length Pbs21. The epitope was identified within the second EGF-like domain of the Pbs21 molecule.

Journal article

Shaw MK, Thompson J, Sinden RE, 1996, Localization of ribosomal RNA and Pbs21-mRNA in the sexual stages of Plasmodium berghei using electron microscope in situ hybridization, EUROPEAN JOURNAL OF CELL BIOLOGY, Vol: 71, Pages: 270-276, ISSN: 0171-9335

Journal article

Jones IW, Thomsen LL, Knowles R, Gutteridge WE, Butcher GA, Sinden REet al., 1996, Nitric oxide synthase activity in malaria-infected mice, PARASITE IMMUNOLOGY, Vol: 18, Pages: 535-538, ISSN: 0141-9838

Journal article

Allsopp CEM, Plebanski M, Gilbert S, Sinden RE, Harris S, Frankel G, Dougan G, Hioe C, Nixon D, Paoletti E, Layton G, Hill AVSet al., 1996, Comparison of numerous delivery systems for the induction of cytoxic T lymphocytes by immunization, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 26, Pages: 1951-1959, ISSN: 0014-2980

Journal article

Fleck SL, Pudney M, Sinden RE, 1996, The effect of atovaquone (566C80) on the maturation and viability of Plasmodium falciparum gametocytes in vitro, TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, Vol: 90, Pages: 309-312, ISSN: 0035-9203

Journal article

Matsuoka H, Kobayashi J, Barker GC, Miura K, Chinzei Y, Miyajima S, Ishii A, Sinden REet al., 1996, Induction of anti-malarial transmission blocking immunity with a recombinant ookinete surface antigen of Plasmodium berghei produced in silkworm larvae using the baculovirus expression vector system, VACCINE, Vol: 14, Pages: 120-126, ISSN: 0264-410X

Journal article

Sinden RE, Butcher GA, Billker O, Fleck SLet al., 1996, Regulation of infectivity of Plasmodium to the mosquito vector, ADVANCES IN PARASITOLOGY, VOL 38, Vol: 38, Pages: 53-117, ISSN: 0065-308X

Journal article

ROBSON KJH, FREVERT U, RECKMANN I, COWAN G, BEIER J, SCRAGG IG, TAKEHARA K, BISHOP DHL, PRADEL G, SINDEN R, SACCHEO S, MULLER HM, CRISANTI Aet al., 1995, THROMBOSPONDIN-RELATED ADHESIVE PROTEIN (TRAP) OF PLASMODIUM-FALCIPARUM - EXPRESSION DURING SPOROZOITE ONTOGENY AND BINDING TO HUMAN HEPATOCYTES, EMBO JOURNAL, Vol: 14, Pages: 3883-3894, ISSN: 0261-4189

Journal article

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