Imperial College London
Alternate

Emeritus ProfessorRobertSinden

Faculty of Natural Sciences, Department of Life Sciences

Emeritus Professor of Parasite Cell Biology
 
 
 
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Contact

 

r.sinden Website

 
 
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Location

 

2.1Centre for Population BiologySilwood Park

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Summary

 

Publications

Citation

BibTex format

@article{Churcher:2017:10.1371/journal.ppat.1006108,
author = {Churcher, TS and Sinden, RE and Edwards, NJ and Poulton, ID and Rampling, TW and Brock, PM and Griffin, JT and Upton, LM and Zakutansky, SE and Sala, KA and Angrisano, F and Hill, AV and Blagborough, AM},
doi = {10.1371/journal.ppat.1006108},
journal = {PLOS Pathogens},
title = {Probability of transmission of malaria from mosquito to human Is regulated by mosquito parasite density in naïve and vaccinated hosts},
url = {http://dx.doi.org/10.1371/journal.ppat.1006108},
volume = {13},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Over a century since Ronald Ross discovered that malaria is caused by the bite of an infectious mosquito it is still unclear how the number of parasites injected influences disease transmission. Currently it is assumed that all mosquitoes with salivary gland sporozoites are equally infectious irrespective of the number of parasites they harbour, though this has never been rigorously tested. Here we analyse >1000 experimental infections of humans and mice and demonstrate a dose-dependency for probability of infection and the length of the host pre-patent period. Mosquitoes with a higher numbers of sporozoites in their salivary glands following blood-feeding are more likely to have caused infection (and have done so quicker) than mosquitoes with fewer parasites. A similar dose response for the probability of infection was seen for humans given a pre-erythrocytic vaccine candidate targeting circumsporozoite protein (CSP), and in mice with and without transfusion of anti-CSP antibodies. These interventions prevented infection more efficiently from bites made by mosquitoes with fewer parasites. The importance of parasite number has widespread implications across malariology, ranging from our basic understanding of the parasite, how vaccines are evaluated and the way in which transmission should be measured in the field. It also provides direct evidence for why the only registered malaria vaccine RTS,S was partially effective in recent clinical trials.
AU  - Churcher,TS
AU  - Sinden,RE
AU  - Edwards,NJ
AU  - Poulton,ID
AU  - Rampling,TW
AU  - Brock,PM
AU  - Griffin,JT
AU  - Upton,LM
AU  - Zakutansky,SE
AU  - Sala,KA
AU  - Angrisano,F
AU  - Hill,AV
AU  - Blagborough,AM
DO  - 10.1371/journal.ppat.1006108
PY  - 2017///
SN  - 1553-7366
TI  - Probability of transmission of malaria from mosquito to human Is regulated by mosquito parasite density in naïve and vaccinated hosts
T2  - PLOS Pathogens
UR  - http://dx.doi.org/10.1371/journal.ppat.1006108
UR  - http://www.ncbi.nlm.nih.gov/pubmed/28081253
UR  - http://hdl.handle.net/10044/1/44056
VL  - 13
ER  -
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