Publications
13 results found
Cui X, Gong J, Han H, et al., 2018, Relationship between free and total malondialdehyde, a well-established marker of oxidative stress, in various types of human biospecimens, JOURNAL OF THORACIC DISEASE, Vol: 10, Pages: 3088-+, ISSN: 2072-1439
Krauskopf J, Caiment F, van Veldhoven K, et al., 2018, The human circulating miRNome reflects multiple organ disease risks in association with short-term exposure to traffic-related air pollution, Environment International, Vol: 113, Pages: 26-34, ISSN: 0160-4120
Traffic-related air pollution is a complex mixture of particulate matter (PM) and gaseous pollutants, such as nitrogen dioxide (NO2). PM exposure contributes to the pathogenesis of many diseases including several types of cancer, as well as pulmonary, cardiovascular and neurodegenerative diseases. Also exposure to NO2 has been related to increased cardiovascular mortality. In search of an early diagnostic biomarker for improved air pollution-associated health risk assessment, recent human studies have shown that certain circulating miRNAs are altered upon exposure to traffic-related air pollutants. Here, we present for the first time a global analysis of the circulating miRNA genome in an experimental cross-over study of a human population exposed to traffic-related air pollution. By utilizing next-generation sequencing technology and detailed real-time exposure measurements we identified 54 circulating miRNAs to be dose- and pollutant species-dependently associated with PM10, PM2.5, black carbon, ultrafine particles and NO2 already after 2 h of exposure. Bioinformatics analysis suggests that these circulating miRNAs actually reflect the adverse consequences of traffic pollution-induced toxicity in target tissues including the lung, heart, kidney and brain. This study shows the strong potential of circulating miRNAs as novel biomarkers for environmental health risk assessment.
Sinharay R, Gong J, Barratt B, et al., 2018, Respiratory and cardiovascular responses to walking down a traffic-polluted road compared with walking in a traffic-free area in participants older than 60 years with chronic lung or heart disease and age-matched healthy controls: a randomised, crossover study (vol 391, pg 339, 2017), LANCET, Vol: 391, Pages: 308-308, ISSN: 0140-6736
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- Citations: 1
Liu S, Grigoryan H, Edmands WMB, et al., 2018, Cys34 Adductomes Differ between Patients with Chronic Lung or Heart Disease and Healthy Controls in Central London, Environmental Science and Technology (Washington), Vol: 52, Pages: 2307-2313, ISSN: 0013-936X
Oxidative stress generates reactive species that modify proteins, deplete antioxidant defenses, and contribute to chronic obstructive pulmonary disease (COPD) and ischemic heart disease (IHD). To determine whether protein modifications differ between COPD or IHD patients and healthy subjects, we performed untargeted analysis of adducts at the Cys34 locus of human serum albumin (HSA). Biospecimens were obtained from nonsmoking participants from London, U.K., including healthy subjects (n = 20) and patients with COPD (n = 20) or IHD (n = 10). Serum samples were digested with trypsin and analyzed by liquid chromatography-high resolution mass spectrometry. Effects of air pollution on adduct levels were also investigated based on estimated residential exposures to PM2.5, O3 and NO2. For the 39 adducts with sufficient data, levels were essentially identical in blood samples collected from the same subjects on two consecutive days, consistent with the 28 day residence time of HSA. Multivariate linear regression revealed 21 significant associations, mainly with the underlying diseases but also with air-pollution exposures (p-value < 0.05). Interestingly, most of the associations indicated that adduct levels decreased with the presence of disease or increased pollutant concentrations. Negative associations of COPD and IHD with the Cys34 disulfide of glutathione and two Cys34 sulfoxidations, were consistent with previous results from smoking and nonsmoking volunteers and nonsmoking women exposed to indoor combustion of coal and wood.
Sinharay R, Mithra S, Patel P, et al., 2018, EGFR mutation specific immunohistochemistry revolutionises time to treatment with tyrosine kinase inhibitors (TKIs), Publisher: ELSEVIER IRELAND LTD, Pages: S24-S24, ISSN: 0169-5002
Sinharay R, Barratt B, Gong J, et al., 2014, THE EFFECTS OF REAL-WORLD EXPOSURES TO DIESEL TRAFFIC EMISSIONS ON CARDIO-RESPIRATORY OUTCOMES IN COPD : 'OXFORD STREET 2', Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A56-A56, ISSN: 0040-6376
Saito J, Mackay AJ, Rossios C, et al., 2014, Sputum-to-serum hydrogen sulfide ratio in COPD, THORAX, Vol: 69, Pages: 903-909, ISSN: 0040-6376
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- Citations: 20
Sinharay R, Barratt B, Goward C, et al., 2014, Cardio-respiratory outcomes in COPD folio ng ambient exposures to diesel traffic emissions:"Oxford Street 2", Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
Saito J, Mackay A, Rossios C, et al., 2014, Hydrogen sulfide (H<sub>2</sub>S) in sputum and serum as a novel biomarker of COPD, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
Saito J, Mackay A, Rossios C, et al., 2014, Hydrogen sulfide (H<sub>2</sub>S) in sputum and serum as a novel biomarker of COPD, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
Sinharay R, Barratt B, Meesang W, et al., 2014, Ambient Exposure To Diesel Traffic Particles And Cardio-Respiratory Outcomes In Healthy And In COPD Subjects: 'oxford Street 2', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 189, ISSN: 1073-449X
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- Citations: 2
Sinharay R, Barratt B, Rocha JP, et al., 2013, AMBIENT EXPOSURE TO DIESEL TRAFFIC PARTICLES AND CARDIO-RESPIRATORY OUTCOMES IN HEALTHY AND IN COPD SUBJECTS: 'OXFORD STREET 2', Winter Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A129-A130, ISSN: 0040-6376
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- Citations: 2
Leese GP, Morris AD, Swaminathan K, et al., 2005, Implementation of national diabetes retinal screening programme is associated with a lower proportion of patients referred to ophthalmology, DIABETIC MEDICINE, Vol: 22, Pages: 1112-1115, ISSN: 0742-3071
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- Citations: 33
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