Roberto Solari is a Visiting Professor within the Infection in Airway Disease research group, Respiratory Infections section within the National Heart and Lung Institute.
Professor Solari obtained his first class BSc from Nottingham University in 1978 followed by his PhD in 1981 for which he studied the receptor mediated transmission of IgG from mothers to neonates via intestinal uptake. He went on to do a post-doc at the Institut de Biochimie, University of Lausanne funded by a Royal Society European Fellowship and followed this with a second post-doc in the Department of Cell Biology, Liverpool University. Both postdoctoral positions researched the receptor mediated transepithelial transport of dimeric IgA into mother’s milk.
In 1986, Professor Solari joined Glaxo and worked on inflammation and allergy drug discovery. He has since held a number of research posts in industry working from target discovery through to human clinical trials. Most recently, he was Vice President in the Respiratory Therapy Area at GSK leading a unit working the discovery of novel asthma drugs. Roberto has also been involved with the creation of UK start-up companies such as Astex Pharmaceuticals, Lorantis, Chroma Therapeutics and Heptares.
His industrial research interests have broadly been in drug discovery in inflammation and allergy, but as a cell biologist his main scientific interest has been in the functioning of the secretory pathway.
His current research is on the interaction between human Rhinovirus and the host cell in particular how the virus hijacks the cellular ER and Golgi membranes in order to replicate. The aim is to discover novel targets to allow the development of anti-viral drugs.
Solari R, Kraehenbuhl JP, 1984, Biosynthesis of the IgA antibody receptor: a model for the transepithelial sorting of a membrane glycoprotein., Cell, Vol:36, ISSN:0092-8674, Pages:61-71
et al., 1989, RECEPTOR-MEDIATED ENDOCYTOSIS AND NUCLEAR TRANSPORT OF HUMAN INTERLEUKIN-1-ALPHA, Biochemical Journal, Vol:264, ISSN:0264-6021, Pages:813-822
et al., 1993, POLYMORPHISM IN HUMAN IL-1 RECEPTOR ANTAGONIST GENE INTRON-2 IS CAUSED BY VARIABLE NUMBERS OF AN 86-BP TANDEM REPEAT, Human Genetics, Vol:91, ISSN:0340-6717, Pages:403-404
et al., 1994, RECEPTOR-MEDIATED ENDOCYTOSIS AND INTRACELLULAR FATE OF INTERLEUKIN-1, Biochemical Pharmacology, Vol:47, ISSN:0006-2952, Pages:93-101
et al., 1995, GRANZYME-A IS AN INTERLEUKIN-1-BETA-CONVERTING ENZYME, Journal of Experimental Medicine, Vol:181, ISSN:0022-1007, Pages:1917-1922
et al., 1995, THE STRUCTURE OF RAT ADP-RIBOSYLATION-FACTOR-I (ARF-1) COMPLEXED TO GDP DETERMINED FROM 2 DIFFERENT CRYSTAL FORMS, Nature Structural Biology, Vol:2, ISSN:1072-8368, Pages:797-806
et al., 1996, STAT3 beta, a splice variant of transcription factor STAT3, is a dominant negative regulator of transcription, Journal of Biological Chemistry, Vol:271, ISSN:0021-9258, Pages:13221-13227
et al., 1996, Identification of the homologous beige and Chediak-Higashi syndrome genes., Nature, Vol:382, ISSN:0028-0836, Pages:262-265
Norcott JP, Solari R, Cutler DF, 1996, Targeting of P-selectin to two regulated secretory organelles in PC12 cells, Journal of Cell Biology, Vol:134, ISSN:0021-9525, Pages:1229-1240
et al., 1996, Defining the regions of human interleukin-5 important in receptor binding and cellular activation, Annals of the New York Academy of Sciences, Vol:796, ISSN:0077-8923, Pages:226-234
et al., 1997, Receptor-mediated endocytosis of CC-chemokines, Journal of Biological Chemistry, Vol:272, ISSN:0021-9258, Pages:9617-9620
et al., 1997, An interleukin 5 mutant distinguishes between two functional responses in human eosinophils, Journal of Experimental Medicine, Vol:186, ISSN:0022-1007, Pages:121-129
et al., 1998, RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor, Nature, Vol:393, ISSN:0028-0836, Pages:333-339
et al., 1998, Phospholipase D1 localises to secretory granules and lysosomes and is plasma-membrane translocated on cellular stimulation, Current Biology, Vol:8, ISSN:0960-9822, Pages:835-838
et al., 1998, Conserved in vivo phosphorylation of calnexin at casein kinase II sites as well as a protein kinase C proline-directed kinase site, Journal of Biological Chemistry, Vol:273, ISSN:0021-9258, Pages:17227-17235
et al., 1999, Erp1p and Erp2p, partners for Emp24p and Erv25p in a yeast p24 complex., Molecular Biology of the Cell, Vol:10, ISSN:1059-1524, Pages:1923-1938
et al., 2000, The p24 family member p23 is required for early embryonic development, Current Biology, Vol:10, ISSN:0960-9822, Pages:55-58
et al., 2001, Proteomics characterization of abundant Golgi membrane proteins, Journal of Biological Chemistry, Vol:276, ISSN:0021-9258, Pages:5152-5165
et al., 2001, Reverse genetic analysis of components of the Toll signaling pathway in Caenorhabditis elegans, Current Biology, Vol:11, ISSN:0960-9822, Pages:809-821