Imperial College London
Professor Richard Syms

ProfessorRichardSyms

Faculty of Engineering, Department of Electrical and Electronic Engineering

Professor
 
 
 
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Contact

 

+44 (0)20 7594 6203r.syms

 
 
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Location

 

702Electrical EngineeringSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Syms:2020:10.2147/HMER.S266841,
author = {Syms, R and Khuntikeo, N and Titapun, A and Chamadol, N and Boonphongsathien, W and Sa-Ngiamwibool, P and Taylor-Robinson, S and Wadsworth, C and Zhang, S and Kardoulaki, E},
doi = {10.2147/HMER.S266841},
journal = {Hepatic Medicine : Evidence and Research},
pages = {107--114},
title = {In vitro intraductal MRI and T2 mapping of cholangiocarcinoma using catheter coils},
url = {http://dx.doi.org/10.2147/HMER.S266841},
volume = {2020},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Aim: Diagnostic imaging of early-stage cholangiocarcinoma is challenging. A previous in vitro study of fixed-tissue liver resection specimens investigated T2 mapping as a method of exploiting the locally increased signal-to-noise ratio (SNR) of duodenoscope coils for improved quantitative magnetic resonance imaging (MRI), despite their non-uniform sensitivity. This work applies similar methods to unfixed liver specimens using catheter-based receivers.Methods: Ex vivo intraductal MRI and T2 mapping were carried out at 3T on unfixed resection specimens obtained from cholangiocarcinoma patients immediately after surgery using a catheter coil based on a thin-film magneto-inductive waveguide, inserted directly into an intrahepatic duct.Results: Polypoid intraductal cholangiocarcinoma was imaged using fast spin echo sequences. High resolution T2 maps were extracted by fitting of data obtained at different echo times to mono-exponential models, and disease-induced changes were correlated with histopathology. An increase in T2 was found compared with fixed specimens and differences in T2 allowed the resolution of tumour tissue and malignant features such as polypoid morphology.Conclusions: Despite their limited field of view, useful data can be obtained using catheter coils, and T2 mapping offers an effective method of exploiting their local SNR advantage without the need for image correction.
AU  - Syms,R
AU  - Khuntikeo,N
AU  - Titapun,A
AU  - Chamadol,N
AU  - Boonphongsathien,W
AU  - Sa-Ngiamwibool,P
AU  - Taylor-Robinson,S
AU  - Wadsworth,C
AU  - Zhang,S
AU  - Kardoulaki,E
DO  - 10.2147/HMER.S266841
EP  - 114
PY  - 2020///
SN  - 1179-1535
SP  - 107
TI  - In vitro intraductal MRI and T2 mapping of cholangiocarcinoma using catheter coils
T2  - Hepatic Medicine : Evidence and Research
UR  - http://dx.doi.org/10.2147/HMER.S266841
UR  - https://www.dovepress.com/in-vitro-intraductal-mri-and-t2-mapping-of-cholangiocarcinoma-using-ca-peer-reviewed-article-HMER
UR  - http://hdl.handle.net/10044/1/81387
VL  - 2020
ER  -
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