Imperial College London
Alternate

DrRichardSzydlo

Faculty of Medicine, Department of Immunology and Inflammation

Medical Statistician
 
 
 
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Contact

 

+44 (0)20 3313 2170r.szydlo Website

 
 
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Location

 

4N7Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Little:2022:10.1002/jha2.400,
author = {Little, C and Odho, Z and Szydlo, R and Aw, T-C and Laffan, M and Arachchillage, DRJ},
doi = {10.1002/jha2.400},
journal = {EJHaem},
pages = {317--325},
title = {Impact of aspirin on bleeding and blood product usage in off-pump and on-pump coronary artery bypass graft surgery.},
url = {http://dx.doi.org/10.1002/jha2.400},
volume = {3},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Major bleeding is linked to poorer outcomes following cardiac surgery. Current guidelines recommend continuation of aspirin prior to coronary artery by-pass graft (CABG) but the effect of continuing aspirin in patients with prior indication for aspirin, in particular during off-pump CABG (OPCABG), has not been systematically assessed. In this study, we analysed the effect of continuing aspirin prior to OPCABG and on-pump CABG with respect to bleeding and blood product usage. We compared propensity-matched cohorts of patients who continued aspirin until the day of OPCABG or CABG to controls (no antiplatelet) and to patients discontinuing aspirin 5-7 days prior. Length of hospital stay, 30-day mortality and thromboembolism rates were similar for both OPCABG and CABG. During OPCABG, aspirin-continued patients received more intraoperative red cell units compared to controls without difference in bleeding. Aspirin-continued patients received more blood products perioperatively and bled more than aspirin-discontinued patients undergoing OPCABG. The only difference during CABG was a small increase in the volume of cells salvaged among aspirin-continued patients compared to controls. Current guidelines on the continuation of aspirin prior to CABG and OPCABG are safe. Continuation of aspirin prior to OPCABG may result in more bleeding and blood product usage.
AU  - Little,C
AU  - Odho,Z
AU  - Szydlo,R
AU  - Aw,T-C
AU  - Laffan,M
AU  - Arachchillage,DRJ
DO  - 10.1002/jha2.400
EP  - 325
PY  - 2022///
SP  - 317
TI  - Impact of aspirin on bleeding and blood product usage in off-pump and on-pump coronary artery bypass graft surgery.
T2  - EJHaem
UR  - http://dx.doi.org/10.1002/jha2.400
UR  - https://www.ncbi.nlm.nih.gov/pubmed/35846054
VL  - 3
ER  -
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