Imperial College London
Portrait Picture

Professor Reiko J. Tanaka

Faculty of Engineering, Department of Bioengineering

Professor of Computational Systems Biology & Medicine
 
 
 
//

Contact

 

+44 (0)20 7594 6374r.tanaka Website

 
 
//

Location

 

RSM 3.10Royal School of MinesSouth Kensington Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Jurakic:2021:10.1111/jdv.17132,
author = {Jurakic, Toncic R and Jakasa, I and Sun, Y and Hurault, G and Ljubojevic, Hadzavdic S and Tanaka, R and Kezic, S and Marinovic, B},
doi = {10.1111/jdv.17132},
journal = {Journal of the European Academy of Dermatology and Venereology},
pages = {1186--1196},
title = {Stratum corneum markers of innate and T helper cell-related immunity and their relation to the disease severity in Croatian patients with atopic dermatitis},
url = {http://dx.doi.org/10.1111/jdv.17132},
volume = {35},
year = {2021}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundAtopic dermatitis (AD) presents with the wide spectrum of clinical phenotypes within and between various populations. Recent study showed low frequency of filaggrin lossoffunction (FLG LOF) mutations in Croatian AD patients. At present, there are no data on biomarkers of immune response in Croatian AD patients that might be useful in the selection and monitoring of novel immune therapies.ObjectivesTo investigate levels of cytokines of various signature in the stratum corneum (SC) collected from lesional and nonlesional skin of AD patients and healthy controls and to evaluate their relationship with the severity of disease and skin barrier function.MethodsSC samples were collected from 100 adult patients with moderatetosevere AD and 50 healthy controls. The levels of 21 cytokines were measured by multiplex immunoassay. We conducted machine learning analysis to assess whether a small number of cytokine measurements can discriminate between healthy controls and AD patients and can predict AD severity (SCORAD).ResultsThe SC levels of thirteen cytokines representing innate immunity, Th1, Th2 and Th17/22 immune response showed significant differences between healthy and AD skin. Our analysis demonstrated that as few as three cytokines measured in lesional skin can discriminate healthy controls and AD with an accuracy of 99% and that the predictive models for SCORAD did not achieve a high accuracy. Cytokine levels were highly correlated with the levels of filaggrin degradation products and skin barrier function.ConclusionsStratum corneum analysis revealed aberrant levels of cytokines representing innate immunity, Th1, Th2 and Th17/22mediated immune response in Croatian AD patients. Increased Th2 cytokines and their strong association with natural moisturizing factor (NMF) can explain low NMF levels despite of low frequency of FLG LOF mutations in Croatian population. Predictive models for SCORAD identified cytokines associated with SCORAD but warra
AU  - Jurakic,Toncic R
AU  - Jakasa,I
AU  - Sun,Y
AU  - Hurault,G
AU  - Ljubojevic,Hadzavdic S
AU  - Tanaka,R
AU  - Kezic,S
AU  - Marinovic,B
DO  - 10.1111/jdv.17132
EP  - 1196
PY  - 2021///
SN  - 0926-9959
SP  - 1186
TI  - Stratum corneum markers of innate and T helper cell-related immunity and their relation to the disease severity in Croatian patients with atopic dermatitis
T2  - Journal of the European Academy of Dermatology and Venereology
UR  - http://dx.doi.org/10.1111/jdv.17132
UR  - https://onlinelibrary.wiley.com/doi/10.1111/jdv.17132
UR  - http://hdl.handle.net/10044/1/85144
VL  - 35
ER  -
Download