Imperial College London


Faculty of MedicineNational Heart & Lung Institute

Research Associate







Mint WingSt Mary's Campus





Ryan Thwaites is a Research Associate within the Department of Respiratory Medicine of the National Heart and Lung Institute, Imperial College London. Ryan obtained his PhD in 2015 in the field of innate immunology from the Brighton and Sussex Medical School, University of Sussex. Following on from this work, he joined Professor Peter Openshaw and Professor Trevor Hansel at the NHLI.

His research continues to investigate the activity of the innate immune system in human disease, particularly during the anti-viral immune response. This work uses non-infectious human models of innate immune activation (such as Toll-like receptor agonists), experimental human infection models and natural infection. In addition to these biological interests, Ryan's work has developed non-invasive techniques for sampling the airways of infants during viral infections.



Siggins MK, Thwaites RS, Openshaw PJM, 2021, Durability of Immunity to SARS-CoV-2 and Other Respiratory Viruses., Trends Microbiol, Vol:29, Pages:648-662

Drake TM, Fairfield CJ, Pius R, et al., 2021, Non-steroidal anti-inflammatory drug use and outcomes of COVID-19 in the ISARIC Clinical Characterisation Protocol UK cohort: a matched, prospective cohort study., The Lancet Rheumatology, ISSN:2665-9913

Challenger JD, Foo CY, Wu Y, et al., 2021, Modelling upper respiratory viral load dynamics of SARS-CoV-2

Ogbe A, Kronsteiner B, Skelly DT, et al., 2021, T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses., Nat Commun, Vol:12

Gupta RK, Harrison EM, Ho A, et al., 2021, Development and validation of the ISARIC 4C Deterioration model for adults hospitalised with COVID-19: a prospective cohort study, The Lancet Respiratory Medicine, Vol:9, ISSN:2213-2600, Pages:349-359

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