Imperial College London
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DrRyanThwaites

Faculty of Medicine, National Heart & Lung Institute

Lecturer in Respiratory Immunology
 
 
 
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r.thwaites

 
 
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Location

 

Respiratory InfectionsMedical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@unpublished{Thwaites:2020:10.1101/2020.10.08.20209411,
author = {Thwaites, R and Sevilla, Uruchurtu AS and Siggins, M and Liew, F and Russell, C and Moore, S and Carter, E and Abrams, S and Short, C-E and Thaventhiran, T and Bergstrom, E and Gardener, Z and Ascough, S and Chiu, C and Docherty, A and Hunt, D and Crow, Y and Solomon, T and Taylor, G and Turtle, L and Harrison, E and Semple, M and Baillie, K and Openshaw, PJM},
doi = {10.1101/2020.10.08.20209411},
publisher = {medRxiv},
title = {Elevated antiviral, myeloid and endothelial inflammatory markers in severe COVID-19},
url = {http://dx.doi.org/10.1101/2020.10.08.20209411},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - UNPB
AB  - Introductory paragraph</h4> The mechanisms that underpin COVID-19 disease severity, and determine the outcome of infection, are only beginning to be unraveled. The host inflammatory response contributes to lung injury, but circulating mediators levels fall below those in classical ‘cytokine storms’. We analyzed serial plasma samples from 619 patients hospitalized with COVID-19 recruited through the prospective multicenter ISARIC clinical characterization protocol U.K. study and 39 milder community cases not requiring hospitalization. Elevated levels of numerous mediators including angiopoietin-2, CXCL10, and GM-CSF were seen at recruitment in patients who later died. Markers of endothelial injury (angiopoietin-2 and von-Willebrand factor A2) were detected early in some patients, while inflammatory cytokines and markers of lung injury persisted for several weeks in fatal COVID-19 despite decreasing antiviral cytokine levels. Overall, markers of myeloid or endothelial cell activation were associated with severe, progressive, and fatal disease indicating a central role for innate immune activation and vascular inflammation in COVID-19.
AU  - Thwaites,R
AU  - Sevilla,Uruchurtu AS
AU  - Siggins,M
AU  - Liew,F
AU  - Russell,C
AU  - Moore,S
AU  - Carter,E
AU  - Abrams,S
AU  - Short,C-E
AU  - Thaventhiran,T
AU  - Bergstrom,E
AU  - Gardener,Z
AU  - Ascough,S
AU  - Chiu,C
AU  - Docherty,A
AU  - Hunt,D
AU  - Crow,Y
AU  - Solomon,T
AU  - Taylor,G
AU  - Turtle,L
AU  - Harrison,E
AU  - Semple,M
AU  - Baillie,K
AU  - Openshaw,PJM
DO  - 10.1101/2020.10.08.20209411
PB  - medRxiv
PY  - 2020///
TI  - Elevated antiviral, myeloid and endothelial inflammatory markers in severe COVID-19
UR  - http://dx.doi.org/10.1101/2020.10.08.20209411
UR  - http://hdl.handle.net/10044/1/101271
ER  -
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