Imperial College London
Alternate

DrRobinTyacke

Faculty of Medicine, Department of Brain Sciences

Research Manager
 
 
 
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Contact

 

+44 (0)20 7594 7096r.tyacke

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@inbook{Bosker:2014:10.1007/978-3-642-40384-2_3,
author = {Bosker, FJ and Doorduin, J and Jongsma, ME and Visser, AKD and Dehaes, JU and Cremers, TIFH and Rea, K and Tyacke, R and Nutt, DJ and den, Boer JA and Westerink, BHC},
booktitle = {PET and SPECT in Psychiatry},
doi = {10.1007/978-3-642-40384-2_3},
pages = {45--63},
title = {Pharmacological interventions that have the potential to alter neurotransmitter levels in the human brain},
url = {http://dx.doi.org/10.1007/978-3-642-40384-2_3},
year = {2014}
}
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RIS format (EndNote, RefMan)

TY  - CHAP
AB  - Monitoring of neuronal activity in vivo is one of the greatest challenges in neuropsychiatry. Theoretically, levels of intra and extra synaptic neurotransmitters can be estimated through competition with suitable PET ligands at their receptors. When validating candidate receptor PET ligands for competition studies it is essential to manipulate neurotransmitter levels in vivo using interventions with drugs that have negligible affinity for the receptors aimed at and are allowed to be used in humans. Neurochemical evidence for pharmacological interventions mostly originates from microdialysis studies in animals. First we will give a brief historical and methodological overview of the microdialysis technique. We will focus on serotonin and present microdialysis data of various pharmacological interventions in rats that have the potential to alter serotonin levels in humans. Our primary aim is to broaden the arsenal of pharmacological tools for PET competition studies, in particular because the type of neuronal manipulation might be a critical factor. Microdialysis of glutamate is briefly discussed, merely to illustrate some of the shortcomings of the technique.
AU  - Bosker,FJ
AU  - Doorduin,J
AU  - Jongsma,ME
AU  - Visser,AKD
AU  - Dehaes,JU
AU  - Cremers,TIFH
AU  - Rea,K
AU  - Tyacke,R
AU  - Nutt,DJ
AU  - den,Boer JA
AU  - Westerink,BHC
DO  - 10.1007/978-3-642-40384-2_3
EP  - 63
PY  - 2014///
SN  - 9783642403835
SP  - 45
TI  - Pharmacological interventions that have the potential to alter neurotransmitter levels in the human brain
T1  - PET and SPECT in Psychiatry
UR  - http://dx.doi.org/10.1007/978-3-642-40384-2_3
ER  -
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