23 results found
Bergner R, Onida S, Velineni R, et al., 2021, Metabolic profiling reveals changes in serum predictive of venous ulcer healing, Annals of Surgery, ISSN: 0003-4932
Objective: The aim of this study was to identify potential biomarkers predictive of healing or failure to heal in a population with venous leg ulceration.Summary Background Data: Venous leg ulceration presents important physical, psychological, social and financial burdens. Compression therapy is the main treatment, but it can be painful and time-consuming, with significant recurrence rates. The identification of a reliable biochemical signature with the ability to identify nonhealing ulcers has important translational applications for disease prognostication, personalized health care and the development of novel therapies.Methods: Twenty-eight patients were assessed at baseline and at 20 weeks. Untargeted metabolic profiling was performed on urine, serum, and ulcer fluid, using mass spectrometry and nuclear magnetic resonance spectroscopy.Results: A differential metabolic phenotype was identified in healing (n = 15) compared to nonhealing (n = 13) venous leg ulcer patients. Analysis of the assigned metabolites found ceramide and carnitine metabolism to be relevant pathways. In this pilot study, only serum biofluids could differentiate between healing and nonhealing patients. The ratio of carnitine to ceramide was able to differentiate between healing phenotypes with 100% sensitivity, 79% specificity, and 91% accuracy.Conclusions: This study reports a metabolic signature predictive of healing in venous leg ulceration and presents potential translational applications for disease prognostication and development of targeted therapies.
MacLeod CS, Velineni R, 2021, An Aortic Band, EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, Vol: 61, Pages: 394-394, ISSN: 1078-5884
Velineni R, Falah O, 2021, Infrarenal Aorto to Brachiocephalic and Left Carotid Artery Bypass With Full Arch TEVAR for Retrograde Type A Dissection, EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, Vol: 61, Pages: 269-269, ISSN: 1078-5884
Epstein DM, Gohel MS, Heatley F, et al., 2019, Cost-effectiveness analysis of a randomized clinical trial of early versus deferred endovenous ablation of superficial venous reflux in patients with venous ulceration, British Journal of Surgery, Vol: 106, Pages: 555-562, ISSN: 0007-1323
BackgroundTreatment of superficial venous reflux in addition to compression therapy accelerates venous leg ulcer healing and reduces ulcer recurrence. The aim of this study was to evaluate the costs and cost‐effectiveness of early versus delayed endovenous treatment of patients with venous leg ulcers.MethodsThis was a within‐trial cost‐utility analysis with a 1‐year time horizon using data from the EVRA (Early Venous Reflux Ablation) trial. The study compared early versus deferred endovenous ablation for superficial venous truncal reflux in patients with a venous leg ulcer. The outcome measure was the cost per quality‐adjusted life‐year (QALY) over 1 year. Sensitivity analyses were conducted with alternative methods of handling missing data, alternative preference weights for health‐related quality of life, and per protocol.ResultsAfter early intervention, the mean(s.e.m.) cost was higher (difference in cost per patient £163(318) (€184(358))) and early intervention was associated with more QALYs at 1 year (mean(s.e.m.) difference 0·041(0·017)). The incremental cost‐effectiveness ratio (ICER) was £3976 (€4482) per QALY. There was an 89 per cent probability that early venous intervention is cost‐effective at a threshold of £20 000 (€22 546)/QALY. Sensitivity analyses produced similar results, confirming that early treatment of superficial reflux is highly likely to be cost‐effective.ConclusionEarly treatment of superficial reflux is highly likely to be cost‐effective in patients with venous leg ulcers over 1 year. Registration number: ISRCTN02335796 (http://www.isrctn.com).
Singh AA, Velineni R, Varty K, et al., 2019, Bilateral Extracranial Internal Carotid Artery Aneurysms in a Patient with Marfan Syndrome: Case Report and Review of the Literature., EJVES Short Rep, Vol: 45, Pages: 14-16
Introduction: Aneurysms of the extracranial carotid artery are rare. They are often asymptomatic but can lead to disabling stroke. This report describes a case of bilateral internal carotid artery aneurysms in a patient with Marfan syndrome. Report: A 65 year old woman with Marfan syndrome presented with an asymptomatic swelling in the right anterior triangle of the neck. Imaging revealed bilateral extracranial fusiform internal carotid artery aneurysms. Staged open repair was performed. The right side was repaired by aneurysm excision and primary end to end anastomosis. The left side was repaired with a great saphenous vein interposition graft. The patient is free from aneurysm related complications at six years, although recurrent dilatation is present on surveillance. Discussion: Internal carotid aneurysms can be managed successfully by open repair. In patients with connective tissue disorders surveillance is required to monitor for post-operative aneurysmal dilatation.
Velineni R, Spagou K, Gohel MS, et al., 2016, Metabolic profiling in chronic venous ulceration of the lower limb - a potential tool for discovering biomarkers of prognosis?, Annual Meeting of the Society-of-Academic-and-Research-Surgery (SARS), Publisher: Wiley, Pages: 11-11, ISSN: 1365-2168
Warwick AM, Velineni R, Smart NJ, et al., 2016, Onlay parastomal hernia repair with cross-linked porcine dermal collagen biologic mesh: long-term results, HERNIA, Vol: 20, Pages: 321-325, ISSN: 1265-4906
Harris SA, Velineni R, Davies AH, 2015, Inferior Vena Cava Filters in Pregnancy: A Systematic Review., Journal of Vascular and Interventional Radiology, Vol: 27, Pages: 354-360.e8, ISSN: 1535-7732
During pregnancy, patients have an increased risk of venous thromboembolism (VTE). This is an important cause of maternal mortality. Inferior vena cava (IVC) filters can be used to prevent pulmonary embolism in complicated cases of VTE during pregnancy. The present systematic review includes all patients reported in the literature who had an IVC filter placed during pregnancy. The indications for IVC filters are discussed, along with practical considerations for placement during pregnancy, filter effectiveness, and maternal and fetal mortality and morbidity. IVC filters can be used safely when appropriate during pregnancy, with complication rates similar to those in nonpregnant patients.
Mittapalli D, Velineni R, Rae N, et al., 2015, Necrotizing Soft Tissue Infections in Intravenous Drug Users: A Vascular Surgical Emergency, EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, Vol: 49, Pages: 593-599, ISSN: 1078-5884
Spagou K, Velineni R, Penn JW, et al., 2015, Metabolic profiling of patients with differing severity of venous disease, Annual Meeting of the Society-of-Academic-and-Research-Surgery (SARS(, Publisher: WILEY-BLACKWELL, Pages: 5-5, ISSN: 0007-1323
Mittapalli D, Velineni R, Rae N, et al., 2015, Necrotizing Soft Tissue Infections in Intravenous Drug Users - A Vascular Surgical Emergency?, Publisher: WILEY-BLACKWELL, Pages: 23-23, ISSN: 0007-1323
Velineni R, Spagou K, Gohel MS, et al., 2014, Metabolic profiling in chronic venous ulceration of the lower limb - a new approach to an old problem?, Annual Meeting of the Society-of-Academic-and-Research-Surgery, Publisher: WILEY-BLACKWELL, Pages: 38-38, ISSN: 0007-1323
Bhangu A, Singh P, Panagiotopoulou IG, et al., 2014, Safety of Short, In-Hospital Delays Before Surgery for Acute Appendicitis, ANNALS OF SURGERY, Vol: 259, Pages: 894-903, ISSN: 0003-4932
Roxburgh CS, Richards CH, O'Neill S, et al., 2014, A national survey of attitudes to research in Scottish General Surgery Trainees, SCOTTISH MEDICAL JOURNAL, Vol: 59, Pages: 9-15, ISSN: 0036-9330
Velineni R, Spagou K, Gohel MS, et al., 2014, Metabolic Profiling in Chronic Venous Ulceration of the Lower Limb: A New Approach to an Old Problem?, J Vasc Surg Venous Lymphat Disord, Vol: 2, ISSN: 2213-333X
Bhangu A, Richardson C, Torrance A, et al., 2013, Multicentre observational study of performance variation in provision and outcome of emergency appendicectomy, BRITISH JOURNAL OF SURGERY, Vol: 100, Pages: 1240-1252, ISSN: 0007-1323
Dalton RSJ, Velineni R, Osborne ME, et al., 2012, A single-centre experience of chemoradiotherapy for rectal cancer: is there potential for nonoperative management?, COLORECTAL DISEASE, Vol: 14, Pages: 567-571, ISSN: 1462-8910
Colvin HS, Velineni R, Robertson AGN, et al., 2012, Letter 2: Routine colonoscopy following acute uncomplicated diverticulitis (Br J Surg 2011; 98: 1630-1634), BRITISH JOURNAL OF SURGERY, Vol: 99, Pages: 300-300, ISSN: 0007-1323
Smart NJ, Velineni R, Khan D, et al., 2011, Parastomal hernia repair outcomes in relation to stoma site with diisocyanate cross-linked acellular porcine dermal collagen mesh, HERNIA, Vol: 15, Pages: 433-437, ISSN: 1265-4906
Velineni R, Smart N, Daniels I, 2010, Bioprosthetics in Parastomal Hernia Repair, DISEASES OF THE COLON & RECTUM, Vol: 53, Pages: 1342-1343, ISSN: 0012-3706
Williams JP, Velineni R, Veeramootoo D, et al., 2010, Survival following recurrence after minimally invasive oesophagectomy for cancer, Electronic Poster of Distinction in Association-of-Surgeons-of-Great-Britain-and-Ireland-International-Surgical-Congress, Publisher: WILEY-BLACKWELL, Pages: 20-20, ISSN: 0007-1323
Velineni R, Williams JP, Veeramootoo D, et al., 2010, Predictors of early recurrence after minimally invasive oesophagectomy for cancer, Electronic Poster of Distinction in Association-of-Surgeons-of-Great-Britain-and-Ireland-International-Surgical-Congress, Publisher: WILEY-BLACKWELL, Pages: 89-89, ISSN: 0007-1323
Velineni R, 2005, Foundation year for newly qualified doctors - A house officer writes, BRITISH MEDICAL JOURNAL, Vol: 331, Pages: 697-697, ISSN: 0959-8146
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