Publications
205 results found
Jimeno C, Christmann U, Escudero-Adan EC, et al., 2012, Studies on the Amination of Aryl Chlorides with a Monoligated Palladium Catalyst: Kinetic Evidence for a Cooperative Mechanism, CHEMISTRY-A EUROPEAN JOURNAL, Vol: 18, Pages: 16510-16516, ISSN: 0947-6539
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- Citations: 17
Suntharalingam K, Hunt DJ, Duarte AA, et al., 2012, A Tri-copper(II) Complex Displaying DNA-Cleaving Properties and Antiproliferative Activity against Cancer Cells, CHEMISTRY-A EUROPEAN JOURNAL, Vol: 18, Pages: 15133-15141, ISSN: 0947-6539
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- Citations: 70
Tate CW, Gee AD, Vilar R, et al., 2012, Reversible carbon monoxide binding at copper(I) P-S-X (<i>X</i>=N, O) coordination polymers, JOURNAL OF ORGANOMETALLIC CHEMISTRY, Vol: 715, Pages: 39-42, ISSN: 0022-328X
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- Citations: 1
Herranz F, Schmidt-Weber CB, Shamji MH, et al., 2012, Superparamagnetic iron oxide nanoparticles conjugated to a grass pollen allergen and an optical probe, CONTRAST MEDIA & MOLECULAR IMAGING, Vol: 7, Pages: 435-439, ISSN: 1555-4309
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- Citations: 7
Campbell NH, Abd Karim NH, Parkinson GN, et al., 2012, Molecular Basis of Structure-Activity Relationships between Salphen Metal Complexes and Human Telomeric DNA Quadruplexes, JOURNAL OF MEDICINAL CHEMISTRY, Vol: 55, Pages: 209-222, ISSN: 0022-2623
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- Citations: 182
Marti-Centelles V, Isabel Burguete M, Galindo F, et al., 2012, Fluorescent Acridine-Based Receptors for H<sub>2</sub>PO<sub>4</sub><SUP>-</SUP>, JOURNAL OF ORGANIC CHEMISTRY, Vol: 77, Pages: 490-500, ISSN: 0022-3263
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- Citations: 51
Leczkowska A, Vilar R, 2012, Interaction of metal complexes with nucleic acids, ANNUAL REPORTS ON THE PROGRESS OF CHEMISTRY, SECTION A: INORGANIC CHEMISTRY, VOL 108, Vol: 108, Pages: 330-349, ISSN: 0260-1818
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- Citations: 8
Gong X, Miller PW, Gee AD, et al., 2012, Gas–Liquid Segmented Flow Microfluidics for Screening Pd-Catalyzed Carbonylation Reactions, Chemistry: A European Journal, Vol: 18, Pages: 2768-2772
Tate CW, deMello A, Gee AD, et al., 2012, Hemilabile and reversible carbon monoxide binding properties of iron(II), cobalt(II) and nickel(II) complexes containing a new tridentate P-S-N ligand, DALTON TRANSACTIONS, Vol: 41, Pages: 83-89, ISSN: 1477-9226
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- Citations: 12
Child ES, Georgiades SN, Rose KN, et al., 2011, Inhibition of mitogen-activated protein kinase (MAPK) and cyclin-dependent kinase 2 (Cdk2) by platinum(II) phenanthroline complexes., J Chem Biol, Vol: 4, Pages: 159-165
UNLABELLED: Inhibition of protein kinases in the fight against disease remains a constant challenge for medicinal chemists, who have screened multitudes of predominantly planar organic scaffolds, natural and synthetic, to identify potent-albeit not always selective-kinase inhibitors. Herein, in an effort to investigate the potential biological utility of metal-based compounds as inhibitors against the cancer-relevant targets mitogen-activated protein kinase and cyclin-dependent kinase 2, we explore various parameters in planar platinum(II) complexes with substituted phenanthroline ligands and aliphatic diamine chelate co-ligands, to identify combinations that yield promising inhibitory activity. The individual ligands' steric requirements as well as their pattern of hydrogen bond donors/acceptors appear to alter inhibitory potency when modulated. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s12154-011-0059-5) contains supplementary material, which is available to authorized users.
Mak LH, Georgiades SN, Rosivatz E, et al., 2011, A Small Molecule Mimicking a Phosphatidylinositol (4,5)-Bisphosphate Binding Pleckstrin Homology Domain, ACS Chemical Biology, ISSN: 1554-8929
Campbelll NH, Karim NHA, Parkinson GN, et al., 2011, The first crystal structure of a telomeric quadruplex DNA with a metal containing ligand, CANCER RESEARCH, Vol: 71, ISSN: 0008-5472
Georgiades S, Mak L, Angurell I, et al., 2011, Identification of a potent activator of Akt phosphorylation from a novel series of phenolic, picolinic, pyridino, and hydroxamic zinc(II) complexes, Journal of Biological Inorganic Chemistry, Vol: 16, Pages: 195-208, ISSN: 0949-8257
Miller PW, Audrain H, Bender D, et al., 2011, Rapid Carbon-11 Radiolabelling for PET Using Microfluidics, Chemistry - A European Journal, Vol: 17, Pages: 460-463
Surman AJ, Bonnet CS, Lowe MP, et al., 2011, A Pyrophosphate-Responsive Gadolinium(III) MRI Contrast Agent, Chemistry - A European Journal, Vol: 17, Pages: 223-230, ISSN: 0947-6539
Marti-Centelles V, Kumar DK, White AJP, et al., 2011, Zinc(ii) coordination polymers with pseudopeptidic ligands, CrystEngComm, Vol: 13, Pages: 6997-7008
Two new phenyl-bridged pseudopeptidic ligands have been prepared and structurally characterised. The nature of the ligands' substituents play an important role in the nature of the solid state structure yielding either hydrogen bonded linked sheets of molecules or infinite hydrogen bonded networks. Both these ligands were reacted with a range of zinc(ii) salts with the aim of synthesising coordination polymers and networks and exploring the role that anions could play in determining the final structure. The crystal structures of four of these systems (with ZnSO4 and ZnBr2) were determined; in one case, a 3D coordination network was obtained where zinc-ligand coordination bonds generated the 3D arrangements. Three other 3D networks were obtained by anion-mediated hydrogen bonding of coordination 1D chains or 2D sheets. These four very different structures highlight the important role played by the ligands' substituents and the counteranions present in the system.
D'Arcy M, Weiss DJ, Bluck M, et al., 2011, Adsorption kinetics, capacity and mechanism of arsenate and phosphate on a bifunctional TiO2-Fe2O3 bi-composite, Journal of Colloid and Interface Science, Vol: 364, Pages: 205-212
Surman AJ, Kenny GD, Kumar DK, et al., 2011, Targeting of anionic membrane species by lanthanide(iii) complexes: towards improved MRI contrast agents for apoptosis, Chemical Communications, ISSN: 1359-7345
Buscemi G, Miller PW, Kealey S, et al., 2011, Rapid carbonylative coupling reactions using palladium(I) dimers: applications to <SUP>11</SUP>CO-radiolabelling for the synthesis of PET tracers, ORGANIC & BIOMOLECULAR CHEMISTRY, Vol: 9, Pages: 3499-3503, ISSN: 1477-0520
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- Citations: 29
Li X, Nazeeruddin MK, Thelakkat M, et al., 2011, Spectroelectrochemical studies of hole percolation on functionalised nanocrystalline TiO<sub>2</sub> films: a comparison of two different ruthenium complexes, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, Vol: 13, Pages: 1575-1584, ISSN: 1463-9076
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- Citations: 32
Suntharalingam K, Vilar R, 2011, Interaction of metal complexes with nucleic acids, ANNUAL REPORTS ON THE PROGRESS OF CHEMISTRY, SECTION A: INORGANIC CHEMISTRY, VOL 107, Vol: 107, Pages: 339-358, ISSN: 0260-1818
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- Citations: 9
Mak L, Vilar R, Woscholski R, 2010, Characterisation of the PTEN inhibitor VO-OHpic, Journal of Chemical Biology, Vol: 3, Pages: 157-163, ISSN: 1864-6158
Suntharalingam K, White AJP, Vilar R, 2010, Two Metals Are Better than One: Investigations on the Interactions between Dinuclear Metal Complexes and Quadruplex DNA, INORGANIC CHEMISTRY, Vol: 49, Pages: 8371-8380, ISSN: 0020-1669
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- Citations: 93
Vilar R, Suntharalingam K, 2010, Two metals are better than one: Interactions between dinuclear metal complexes and quadruplex DNA, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol: 240, ISSN: 0065-7727
Georgiades SN, Vilar R, 2010, Interaction of metal complexes with nucleic acids, ANNUAL REPORTS ON THE PROGRESS OF CHEMISTRY, SECTION A: INORGANIC CHEMISTRY, VOL 106, Vol: 106, Pages: 481-503, ISSN: 0260-1818
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- Citations: 11
Martinelli J, Balali-Mood B, Panizzo R, et al., 2010, Coordination chemistry of amide-functionalised tetraazamacrocycles: structural, relaxometric and cytotoxicity studies, DALTON TRANSACTIONS, Vol: 39, Pages: 10056-10067, ISSN: 1477-9226
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- Citations: 16
He X, Herranz F, Cheng EC-C, et al., 2010, Design, Synthesis, Photophysics, and Anion-Binding Studies of Bis(dicyclohexylphosphino)methane-Containing Dinuclear Gold(I) Thiolate Complexes with Urea Receptors, CHEMISTRY-A EUROPEAN JOURNAL, Vol: 16, Pages: 9123-9131, ISSN: 0947-6539
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- Citations: 47
Suntharalingam K, Gupta D, Miguel PJS, et al., 2010, Synthesis, Structural Characterisation and Quadruplex DNA Binding Studies of a New Gold(III) Pyrazolylpyridine Complex, CHEMISTRY-A EUROPEAN JOURNAL, Vol: 16, Pages: 3613-3616, ISSN: 0947-6539
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- Citations: 27
Georgiades SN, Abd Karim NH, Suntharalingam K, et al., 2010, Interaction of Metal Complexes with G-Quadruplex DNA, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol: 49, Pages: 4020-4034, ISSN: 1433-7851
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- Citations: 394
Owen GR, White AJP, Vilar R, 2009, Palladium Iminoacyl Imine Complexes: Strategies toward Imine Insertion, ORGANOMETALLICS, Vol: 28, Pages: 5783-5793, ISSN: 0276-7333
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- Citations: 9
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