Imperial College London
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Prof. Ramon Vilar

Faculty of Natural Sciences, Department of Chemistry

Prof of Medicinal Inorganic Chemistry & Vice-Dean (Research)
 
 
 
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Contact

 

+44 (0)20 7594 1967r.vilar Website

 
 
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Location

 

301HMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Kench:2020:10.26434/chemrxiv.13249643.v1,
author = {Kench, T and Summers, PA and Kuimova, MK and Lewis, J and Vilar, R},
doi = {10.26434/chemrxiv.13249643.v1},
title = {Rotaxanes as Cages to Control DNA Binding, Cytotoxicity and Cellular Uptake of a Small Molecule},
url = {http://dx.doi.org/10.26434/chemrxiv.13249643.v1},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:p>In this paper we report a unique approach to control the DNA interactions, cellular uptake and cellular localisation of a small molecule. We have designed rotaxanes that include a luminescent DNA binder, a macrocycle that modulates the DNA binding and a stopper that can be cleaved by either light or the activity of an enzyme.</jats:p>
AU  - Kench,T
AU  - Summers,PA
AU  - Kuimova,MK
AU  - Lewis,J
AU  - Vilar,R
DO  - 10.26434/chemrxiv.13249643.v1
PY  - 2020///
TI  - Rotaxanes as Cages to Control DNA Binding, Cytotoxicity and Cellular Uptake of a Small Molecule
UR  - http://dx.doi.org/10.26434/chemrxiv.13249643.v1
ER  -
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