Imperial College London
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Prof. Ramon Vilar

Faculty of Natural Sciences, Department of Chemistry

Prof of Medicinal Inorganic Chemistry & Vice-Dean (Research)
 
 
 
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Contact

 

+44 (0)20 7594 1967r.vilar Website

 
 
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Location

 

301HMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Lo:2021:10.26434/chemrxiv-2021-7g0hb,
author = {Lo, R and Fruhwirth, G and Vilar, R},
doi = {10.26434/chemrxiv-2021-7g0hb},
title = {A quadruplex-DNA binder functionalised with a SPECT probe for in vivo imaging},
url = {http://dx.doi.org/10.26434/chemrxiv-2021-7g0hb},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:p>Guanine-rich sequences of DNA can fold into intramolecular tetra-helical assemblies known as G-quadruplexes (G4). Their formation in vivo has been associated to a range of biological functions and therefore they have been identified as potential drug targets. Consequently, a broad range of small molecules have been developed to target quadruplexes. However, to date, there is very limited information of the biodistribution of quadruplex binders in whole organisms. Here, we report the functionalisation of a well-established G4 DNA binder (based on a square planar platinum(II)-salphen complex) with two different radiolabelled complexes. An 111In-conjugate was successfully used to assess its in vivo distribution in a mouse tumour model using single-photon emission computed tomography (SPECT) imaging. These studies have shown the overall biodistribution of the G4 DNA binder highlighting its accumulation in the tumour.</jats:p>
AU  - Lo,R
AU  - Fruhwirth,G
AU  - Vilar,R
DO  - 10.26434/chemrxiv-2021-7g0hb
PY  - 2021///
TI  - A quadruplex-DNA binder functionalised with a SPECT probe for in vivo imaging
UR  - http://dx.doi.org/10.26434/chemrxiv-2021-7g0hb
ER  -
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