Overview
- Synthesis of metal-containing drugs and study of their interactions with
DNA (as potential anticancer drugs) and proteins (as inhibitors of phosphatases). - Development of metal-containing probes for biomedical imaging (MRI and optical)
- Organometallic chemistry of palladium (cross-coupling reactions, development of
fast chemical processes for PET labelling) - Development of receptors for selective recognition of anions (phosphate, chloride, arsenate)
and cations (mercury, lead) for the development of chemical sensors - Anion templated synthesis of supramolecular assemblies
For more details, visit the group''s website:
http://www3.imperial.ac.uk/medinchem
Collaborators
Kuimova, Marina, Chemistry, Imperial College London
Ying, Liming, NHLI, Imperial College London
Mann, David, Life Sciences, Imperial College London
Woscholski, Rudiger, Chemistry, Imperial College London
Prof. S. Neidle
National Institute of Chemistry
Long, Nick, Chemistry, Imperial College London
Aboagye, Eric, Surgery and Cancer, Imperial College London
Research Staff
Damodaran,DK
Ghosh,S
Leczkowska,A
Mendoza,O
Research Student Supervision
Abd-Karim,NH, PhD Student. Project: INteraction of metal complexes with DNA
Balali-mood,B, PhD Student, Project: Caged Gd(III) complexes as MRI contrast agents
Behjat,H, PhD Student. Project: Development of receptors for inositol phosphates
Cowell,S, PhD Student, Project: MRI probes for the detection of matrix metalloproteinases (MMPs)
Klejevskaja,B, PhD Student, Project:Structural and functional characterization of potential G-quadruplex motif from the promoter region of GATA-4 gene
Li,X, PhD Student. Project: Functionalised nanostructured metal oxides for anion and cation sensing
Moffat,C, PhD Students, Project: Development of arsenate scavvengin and sensing materials
Patel,C, PhD Student. Polymers and gels for phosphate recognition
Shivalingam,A, PhD Student, Investigation into the role of quadruplex DNA sequences in the promoter regions of peptidase
Stafford,V, PhD Student, Project: Interaction of multimetallic complexes and DNA
Suntharalingam,K, PhD Student, Project: Metal complexes as quadruplex DNA stabilisers
Whyte,G, PhD Student. Project: Molecular Receptors for phosphoinositols
Wilson,N, PhD Student. Project: Optical probes for NO and CO sensing