Imperial College London
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Dr Woscholski

Faculty of Natural Sciences, Department of Chemistry

Reader in Chemical Biology
 
 
 
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Contact

 

+44 (0)20 7594 5305r.woscholski

 
 
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Location

 

301LMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Mak:2015:10.1016/j.ymeth.2015.02.007,
author = {Mak, LH and Woscholski, R},
doi = {10.1016/j.ymeth.2015.02.007},
journal = {Methods},
pages = {63--68},
title = {Targeting PTEN using small molecule inhibitors.},
url = {http://dx.doi.org/10.1016/j.ymeth.2015.02.007},
volume = {77-78C},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - PTEN (phosphatase and tensin homologue deleted on chromosome 10) is well known as a tumour suppressor. It's PI(3,4,5)P3 lipid phosphatase activity is an important counteracting mechanism in PI 3-kinase (phosphoinositide 3-kinase) signalling. Furthermore, PTEN lies upstream of Akt kinase, a key enzyme in insulin signalling regulating glucose uptake and cell growth. Therefore, PTEN has recently gained attention as a valuable drug target for the treatment of diabetes, stroke, cardiac infarct and fertility. This review summarizes the use of small molecules as PTEN inhibitors. Currently available methodologies and techniques for accessing PTEN inhibition in vitro and in cellulo will be discussed.
AU  - Mak,LH
AU  - Woscholski,R
DO  - 10.1016/j.ymeth.2015.02.007
EP  - 68
PY  - 2015///
SN  - 1046-2023
SP  - 63
TI  - Targeting PTEN using small molecule inhibitors.
T2  - Methods
UR  - http://dx.doi.org/10.1016/j.ymeth.2015.02.007
UR  - http://hdl.handle.net/10044/1/21652
VL  - 77-78C
ER  -
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