Imperial College London
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DrRachelLai

Faculty of Medicine, Department of Infectious Disease

Non-Clinical Lecturer in Antimicrobial Resistance and Infect
 
 
 
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Contact

 

rachel.lai

 
 
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Location

 

8N12Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Schutz:2018:10.1080/17476348.2018.1515628,
author = {Schutz, C and Davis, AG and Sossen, B and Lai, R and Ntsekhe, M and Harley, YXR and Wilkinson, R},
doi = {10.1080/17476348.2018.1515628},
journal = {Expert Review of Respiratory Medicine},
pages = {881--891},
title = {Corticosteroids as an adjunct to tuberculosis therapy},
url = {http://dx.doi.org/10.1080/17476348.2018.1515628},
volume = {12},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Introduction: Inflammation, or the prolonged resolution of inflammation, contributes to death from tuberculosis. Interest in inflammatory mechanisms and the prospect of beneficial immune modulation as an adjunct to antibacterial therapy has revived and the concept of host directed therapies has been advanced. Such renewed attention has however, overlooked the experience of such therapy with corticosteroids.Areas covered: The authors conducted literature searches and evaluated randomized clinical trials, systematic reviews and current guidelines and summarize these findings. They found evidence of benefit in meningeal and pericardial tuberculosis in HIV-1 uninfected persons, but less so in those HIV-1 coinfected and evidence of harm in the form of opportunist malignancy in those not prescribed antiretroviral therapy. Adjunctive corticosteroids are however of benefit in the treatment and prevention of paradoxical HIV-tuberculosis immune reconstitution inflammatory syndrome.Expert commentary: Further high-quality clinical trials and experimental medicine studies are warranted and analysis of materials arising from such studies could illuminate ways to improve corticosteroid efficacy or identify novel pathways for more specific intervention.
AU  - Schutz,C
AU  - Davis,AG
AU  - Sossen,B
AU  - Lai,R
AU  - Ntsekhe,M
AU  - Harley,YXR
AU  - Wilkinson,R
DO  - 10.1080/17476348.2018.1515628
EP  - 891
PY  - 2018///
SN  - 1747-6348
SP  - 881
TI  - Corticosteroids as an adjunct to tuberculosis therapy
T2  - Expert Review of Respiratory Medicine
UR  - http://dx.doi.org/10.1080/17476348.2018.1515628
UR  - http://hdl.handle.net/10044/1/63780
VL  - 12
ER  -
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