Imperial College London
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DrRachelLai

Faculty of Medicine, Department of Infectious Disease

Non-Clinical Lecturer in Antimicrobial Resistance and Infect
 
 
 
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Contact

 

rachel.lai

 
 
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Location

 

8N12Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@unpublished{Seddon:2019:10.12688/wellcomeopenres.15573.1,
author = {Seddon, J and Wilkinson, R and van, Crevel R and Figaji, A and Thwaites, G},
doi = {10.12688/wellcomeopenres.15573.1},
publisher = {Wellcome Open Research},
title = {Knowledge gaps and research priorities in tuberculous meningitis},
url = {http://dx.doi.org/10.12688/wellcomeopenres.15573.1},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - UNPB
AB  - Tuberculous meningitis (TBM) is the most severe and disabling form of tuberculosis (TB), accounting for around 1-5% of the global TB caseload, with mortality of approximately 20% in children and up to 60% in persons co-infected with human immunodeficiency virus even in those treated. Relatively few centres of excellence in TBM research exist and the field would therefore benefit from greater co-ordination, advocacy, collaboration and early data sharing. To this end, in 2009, 2015 and 2019 we convened the TBM International Research Consortium, bringing together approximately 50 researchers from five continents. The most recent meeting took place on 1 st and 2 nd March 2019 in Lucknow, India. During the meeting, researchers and clinicians presented updates in their areas of expertise, and additionally presented on the knowledge gaps and research priorities in that field. Discussion during the meeting was followed by the development, by a core writing group, of a synthesis of knowledge gaps and research priorities within seven domains, namely epidemiology, pathogenesis, diagnosis, antimicrobial therapy, host-directed therapy, critical care and implementation science. These were circulated to the whole consortium for written input and feedback. Further cycles of discussion between the writing group took place to arrive at a consensus series of priorities. This article summarises the consensus reached by the consortium concerning the unmet needs and priorities for future research for this neglected and often fatal disease.
AU  - Seddon,J
AU  - Wilkinson,R
AU  - van,Crevel R
AU  - Figaji,A
AU  - Thwaites,G
DO  - 10.12688/wellcomeopenres.15573.1
PB  - Wellcome Open Research
PY  - 2019///
TI  - Knowledge gaps and research priorities in tuberculous meningitis
UR  - http://dx.doi.org/10.12688/wellcomeopenres.15573.1
UR  - https://wellcomeopenresearch.org/articles/4-188/v1
UR  - http://hdl.handle.net/10044/1/76109
ER  -
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