Imperial College London
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DrRachelLai

Faculty of Medicine, Department of Infectious Disease

Non-Clinical Lecturer in Antimicrobial Resistance and Infect
 
 
 
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Contact

 

rachel.lai

 
 
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Location

 

8N12Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Lai:2015:10.1038/ncomms9451,
author = {Lai, RPJ and Meintjes, G and Wilkinson, KA and Graham, CM and Marais, S and Van, der Plas H and Deffur, A and Schutz, C and Bloom, C and Munagala, I and Anguiano, E and Goliath, R and Maartens, G and Banchereau, J and Chaussabel, D and O'Garra, A and Wilkinson, RJ},
doi = {10.1038/ncomms9451},
journal = {Nature Communications},
title = {HIV-tuberculosis-associated immune reconstitution inflammatory syndrome is characterized by Toll-like receptor and inflammasome signalling},
url = {http://dx.doi.org/10.1038/ncomms9451},
volume = {6},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Patients with HIV-associated tuberculosis (TB) initiating antiretroviral therapy (ART) may develop immune reconstitution inflammatory syndrome (TB-IRIS). No biomarkers for TB-IRIS have been identified and the underlying mechanisms are unclear. Here we perform transcriptomic profiling of the blood samples of patients with HIV-associated TB. We identify differentially abundant transcripts as early as week 0.5 post ART initiation that predict downstream activation of proinflammatory cytokines in patients who progress to TB-IRIS. At the characteristic time of TB-IRIS onset (week 2), the signature is characterized by over-representation of innate immune mediators including TLR signalling and TREM-1 activation of the inflammasome. In keeping with the transcriptional data, concentrations of plasma cytokines and caspase-1/5 are elevated in TB-IRIS. Inhibition of MyD88 adaptor and group 1 caspases reduces secretion of cytokines including IL-1 in TB-IRIS patients. These data provide insight on the pathogenesis of TB-IRIS and may assist the development of specific therapies.
AU  - Lai,RPJ
AU  - Meintjes,G
AU  - Wilkinson,KA
AU  - Graham,CM
AU  - Marais,S
AU  - Van,der Plas H
AU  - Deffur,A
AU  - Schutz,C
AU  - Bloom,C
AU  - Munagala,I
AU  - Anguiano,E
AU  - Goliath,R
AU  - Maartens,G
AU  - Banchereau,J
AU  - Chaussabel,D
AU  - O'Garra,A
AU  - Wilkinson,RJ
DO  - 10.1038/ncomms9451
PY  - 2015///
SN  - 2041-1723
TI  - HIV-tuberculosis-associated immune reconstitution inflammatory syndrome is characterized by Toll-like receptor and inflammasome signalling
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/ncomms9451
UR  - http://hdl.handle.net/10044/1/33888
VL  - 6
ER  -
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