Imperial College London
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DrRachelLai

Faculty of Medicine, Department of Infectious Disease

Non-Clinical Lecturer in Antimicrobial Resistance and Infect
 
 
 
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Contact

 

rachel.lai

 
 
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Location

 

8N12Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Marais:2016:infdis/jiw561,
author = {Marais, S and Lai, RP-J and Wilkinson, KA and Meintjes, G and O'Garra, A and Wilkinson, RJ},
doi = {infdis/jiw561},
journal = {Journal of Infectious Diseases},
pages = {677--686},
title = {Inflammasome activation underlies central nervous system deterioration in HIV-associated tuberculosis},
url = {http://dx.doi.org/10.1093/infdis/jiw561},
volume = {215},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Tuberculous meningitis (TBM) is a frequent cause of meningitis in individuals with human immunodeficiency virus (HIV) infection, resulting in death in approximately 40% of affected patients. A severe complication of antiretroviral therapy (ART) in these patients is neurological tuberculosis–immune reconstitution inflammatory syndrome (IRIS), but its underlying cause remains poorly understood. To investigate the pathogenesis of TBM-IRIS, we performed longitudinal whole-blood microarray analysis of HIV-infected patients with TBM and reflected the findings at the protein level. Patients in whom TBM-IRIS eventually developed had significantly more abundant neutrophil-associated transcripts, from before development of TBM-IRIS through IRIS symptom onset. After ART initiation, a significantly higher abundance of transcripts associated with canonical and noncanonical inflammasomes was detected in patients with TBM-IRIS than in non-IRIS controls. Whole-blood transcriptome findings complement protein measurement from the site of disease, which together suggest a dominant role for the innate immune system in the pathogenesis of TBM-IRIS.
AU  - Marais,S
AU  - Lai,RP-J
AU  - Wilkinson,KA
AU  - Meintjes,G
AU  - O'Garra,A
AU  - Wilkinson,RJ
DO  - infdis/jiw561
EP  - 686
PY  - 2016///
SN  - 1537-6613
SP  - 677
TI  - Inflammasome activation underlies central nervous system deterioration in HIV-associated tuberculosis
T2  - Journal of Infectious Diseases
UR  - http://dx.doi.org/10.1093/infdis/jiw561
UR  - http://hdl.handle.net/10044/1/41631
VL  - 215
ER  -
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