Imperial College London
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DrRachelLai

Faculty of Medicine, Department of Infectious Disease

Non-Clinical Lecturer in Antimicrobial Resistance and Infect
 
 
 
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rachel.lai

 
 
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Location

 

8N12Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Shenje:2017:10.1016/j.ijcha.2017.10.002,
author = {Shenje, J and Lai, RP and Ross, IL and Mayosi, BM and Wilkinson, RJ and Ntsekhe, M and Wilkinson, KA},
doi = {10.1016/j.ijcha.2017.10.002},
journal = {IJC Heart and Vasculature},
pages = {104--108},
title = {Effect of prednisolone on inflammatory markers in pericardial tuberculosis: A pilot study},
url = {http://dx.doi.org/10.1016/j.ijcha.2017.10.002},
volume = {18},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: Pericardial disorders are a common cause of heart disease, and the most common cause of pericarditis in developing countries is tuberculous (TB) pericarditis. It has been shown that prednisolone added to standard anti-TB therapy leads to a lower rate of constrictive pericarditis. We conducted a pilot study to evaluate the effect of adjunctive prednisolone treatment on the concentration of inflammatory markers in pericardial tuberculosis, in order to inform immunological mechanisms at the disease site. Methods: Pericardial fluid, plasma and saliva samples were collected from fourteen patients with pericardial tuberculosis, at multiple time points. Inflammatory markers were measured using multiplex luminex analysis and ELISA. Results: In samples from 14 patients we confirmed a strongly compartmentalized immune response at the disease site and found that prednisolone significantly reduced IL-6 concentrations in plasma by 8 hours of treatment, IL-1beta concentrations in saliva, as well as IL-8 concentrations in both pericardial fluid and saliva by 24 hours. Conclusion: Monitoring the early effect of adjunctive immunotherapy in plasma or saliva is a possibility in pericarditis.
AU  - Shenje,J
AU  - Lai,RP
AU  - Ross,IL
AU  - Mayosi,BM
AU  - Wilkinson,RJ
AU  - Ntsekhe,M
AU  - Wilkinson,KA
DO  - 10.1016/j.ijcha.2017.10.002
EP  - 108
PY  - 2017///
SN  - 2352-9067
SP  - 104
TI  - Effect of prednisolone on inflammatory markers in pericardial tuberculosis: A pilot study
T2  - IJC Heart and Vasculature
UR  - http://dx.doi.org/10.1016/j.ijcha.2017.10.002
UR  - http://hdl.handle.net/10044/1/58402
VL  - 18
ER  -
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