Imperial College London
Alternate

DrRachelSmith

Faculty of Medicine, School of Public Health

Research Fellow in Population Child Health
 
 
 
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Contact

 

rachel.smith05

 
 
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Location

 

School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@misc{Patjamontri:2021,
author = {Patjamontri, S and Spiers, ADV and Smith, RB and Shen, C and Adaway, J and Keevil, BG and Toledano, MB and Ahmed, F},
title = {Salivary sex steroids as markers of puberty in boys during late childhood and adolescence},
type = {Poster},
url = {https://abstracts.eurospe.org/hrp/0094/hrp0094p2-375},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - GEN
AB  - Introduction: Salivary androgens represent a non-invasive marker of puberty that may have utility in population studies as well as in the clinical arena.Objectives: To establish normal reference values of salivary androgens using LC-MS/MS and demonstrate the correlations between salivary androgens and pubertal development in boys.Methods: School-based adolescent cohort study with two time points for collecting saliva samples two years apart. Five androgens (Testosterone;T, androstenedione; A4, 17-hydroxyprogesterone; 17-OHP, 11-ketotestosterone; 11-KT and 11β-hydroxyandrostenedione; 11OHA4 were analyzed in saliva samples using LC-MS/MS. In addition, self-reported assessment of puberty through the Pubertal Development Scale (PDS) was also collected at both time points. Receiver-operating characteristic (ROC) curves were used to determine the areas under the curves (AUCs), of each androgen as a predictor of self-reported voice maturation.Results: A total of 1,166 saliva samples were available from 929 boys aged between 11-16 years at either baseline or follow up or both time points with the median age of 12.3 yrs (range 11.3-13.2) and 14.3 yrs (range 13.4-15.8) at baseline and follow up time point, respectively. Median salivary T increased from 7 pmol/l (10th,90th centile, 5, 41) in participants aged 11-12 yrs to 122 pmol/l (21.6, 267.4) in participants aged 15-16 yrs and median salivary A4 increased from 53 pmol/l (26.2, 92.0) in participants aged 11-12 yrs to 144 pmol/l (50.7, 241.2) in participants aged 15-16 yrs. In a subgroup analysis of 147 saliva samples that were collected within 90 days before or after PDS, salivary T and A4 concentrations showed the highest correspondence with self-reported voice-breaking (One-way ANOVA P < 0.005). ROC curve analysis showed that a salivary testosterone of 82.7 pmol/l and a salivary A4 of 113.4 pmol/l provided a sensitivity of 77% and 74%, respectively and a specificity of 76% and 74%, respectively. Salivary T concent
AU  - Patjamontri,S
AU  - Spiers,ADV
AU  - Smith,RB
AU  - Shen,C
AU  - Adaway,J
AU  - Keevil,BG
AU  - Toledano,MB
AU  - Ahmed,F
PY  - 2021///
TI  - Salivary sex steroids as markers of puberty in boys during late childhood and adolescence
UR  - https://abstracts.eurospe.org/hrp/0094/hrp0094p2-375
ER  -
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