Imperial College London

DrRakeshSharma

Faculty of MedicineNational Heart & Lung Institute

Honorary Senior Lecturer
 
 
 
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Contact

 

rakesh.sharma

 
 
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Location

 

Department of CardiologyRoyal BromptonRoyal Brompton Campus

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Summary

 

Publications

Publication Type
Year
to

71 results found

Dubrey S, Shah S, Hardman T, Sharma Ret al., 2014, Sarcoidosis: the links between epidemiology and aetiology, POSTGRADUATE MEDICAL JOURNAL, Vol: 90, Pages: 582-589, ISSN: 0032-5473

Journal article

Arnold AD, Kouranos V, Wechalekar K, Baksi J, Khattar R, Lyon AR, Dar O, Wells AU, Sharma Ret al., 2014, Immunosuppressive therapy and upgrade of conventional pacemaker to CRT-D for dilated cardiomyopathy due to cardiac sarcoidosis, with discordance of disease activity between PET-CT and CMR, Annual Meeting of the European-Society-of-Cardiology (ESC), Publisher: OXFORD UNIV PRESS, Pages: 1205-1205, ISSN: 0195-668X

Conference paper

Theron P, Guha K, Mantziari L, Salahuddin S, Sharma R, Jaggar Set al., 2014, General Anesthesia Versus Sedation for Implantation of a Biventricular Pacing Device for Cardiac Resynchronization Therapy, JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA, Vol: 28, Pages: 280-284, ISSN: 1053-0770

Journal article

Guha K, Konstantinou D, Mantziari L, Modi BN, Chandrasekaran B, Khalique Z, McDonagh T, Sharma Ret al., 2014, The impact of age on clinical outcomes following cardiac resynchronisation therapy, JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY, Vol: 39, Pages: 95-102, ISSN: 1383-875X

Journal article

Gulati A, Ismail TF, Jabbour A, Alpendurada F, Guha K, Ismail NA, Raza S, Khwaja J, Brown TDH, Morarji K, Liodakis E, Roughton M, Wage R, Pakrashi TC, Sharma R, Carpenter J-P, Cook SA, Cowie MR, Assomull RG, Pennell DJ, Prasad SKet al., 2013, The Prevalence and Prognostic Significance of Right Ventricular Systolic Dysfunction in Nonischemic Dilated Cardiomyopathy, CIRCULATION, Vol: 128, Pages: 1623-1633, ISSN: 0009-7322

Journal article

Guha K, Mantziari L, Sharma R, McDonagh TA, Gibson D, Duncan AMet al., 2013, A reduction in total isovolumic time with cardiac resynchronisation therapy is a predictor of clinical outcomes, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 168, Pages: 382-387, ISSN: 0167-5273

Journal article

Konstantinou D, Guha K, Cook C, Sharma Ret al., 2013, QRS duration and clinical outcomes in heart failure patients receiving cardiac resynchronization therapy, Congress of the European-Society-of-Cardiology (ESC), Publisher: OXFORD UNIV PRESS, Pages: 585-585, ISSN: 0195-668X

Conference paper

Guha K, Treibel TA, Roussin I, Prasad SK, Duncan M, Brookes C, McDonagh TA, Sharma Ret al., 2013, Treatment of left ventricular non-compaction with cardiac resynchronization therapy, QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, Vol: 106, Pages: 575-579, ISSN: 1460-2725

Journal article

Richardson JA, Hayward C, Khanna A, Williams O, Markides V, Wong T, Sharma RK, Clague JR, Cowie MR, Lyon ARet al., 2013, Predictive value of future ventricular arrhythmic risk in patients with chronic heart failure from annual remote telemonitoring, EUROPEAN JOURNAL OF HEART FAILURE, Vol: 12, Pages: S247-S247, ISSN: 1388-9842

Journal article

Simpkin VL, Tavazzi G, Ludman A, Marino P, Alexander D, Price S, Griffiths M, Sharma R, Cowie MR, Vazir Aet al., 2013, Serial central venous saturations during ultrafiltration can predict acute kidney injury in acutely decompensated heart failure patients, EUROPEAN JOURNAL OF HEART FAILURE, Vol: 12, Pages: S286-S286, ISSN: 1388-9842

Journal article

Honarbakhsh S, Simpkin VL, Griffiths MR, Price S, Sharma RK, Cowie MR, Vazir Aet al., 2013, Survival and characteristics of patients undergoing rescue cardiac resynchronisation therapy in cardiac intensive care, EUROPEAN JOURNAL OF HEART FAILURE, Vol: 12, Pages: S294-S294, ISSN: 1388-9842

Journal article

Guha K, Morley-Smith A, Savage HO, Mcdonagh T, Sharma Ret al., 2013, The effect of upgrade from dual chamber ICD to Cardiac resynchronisation therapy and defibrillator upon ventricular arrhythmia burden, EUROPEAN JOURNAL OF HEART FAILURE, Vol: 12, Pages: S301-S302, ISSN: 1388-9842

Journal article

Demir OM, Darragh K, Pakrashi T, Fallon L, Pryce-Hawkins H, Sharma RK, Vazir A, Prasad SK, Cowie MR, Lyon ARet al., 2013, Integrating the management of elevated resting heart rate in a specialist tertiary centre heart failure clinic, EUROPEAN JOURNAL OF HEART FAILURE, Vol: 12, Pages: S202-S202, ISSN: 1388-9842

Journal article

Shah G, Scadding G, Nguyen-Lu N, Wigmore T, Chenzbraun A, Wechalekar K, Sharma R, Lyon ARet al., 2013, Peri-operative cardiac arrest with ST elevation secondary to gelofusin anaphylaxis - Kounis syndrome in the anaesthetic room, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 164, Pages: E22-E26, ISSN: 0167-5273

Journal article

Mantziari L, Guha K, Senguttuvan NB, Sharma Ret al., 2013, Cardiac resynchronization therapy for critically ill patients with left ventricular systolic dysfunction, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 163, Pages: 141-145, ISSN: 0167-5273

Journal article

Jones DG, Haldar SK, Hussain W, Sharma R, Francis DP, Rahman-Haley SL, McDonagh TA, Underwood SR, Markides V, Wong Tet al., 2013, A randomized trial to assess catheter ablation versus rate control in the management of persistent atrial fibrillation in heart failure, J Am Coll Cardiol, Vol: 61, Pages: 1894-1903, ISSN: 1558-3597

OBJECTIVES: This study sought to compare catheter ablation with rate control for persistent atrial fibrillation (AF) in heart failure (HF). BACKGROUND: The optimal therapy for AF in HF is unclear. Drug-based rhythm control has not proved clinically beneficial. Catheter ablation improves cardiac function in patients with HF, but impact on physiological performance has not been formally evaluated in a randomized trial. METHODS: In a randomized, open-label, blinded-endpoint clinical trial, adults with symptomatic HF, radionuclide left ventricular ejection fraction (EF) </=35%, and persistent AF were assigned to undergo catheter ablation or rate control. Primary outcome was 12-month change in peak oxygen consumption. Secondary endpoints were quality of life, B-type natriuretic peptide, 6-min walk distance, and EF. Results were analyzed by intention-to-treat. RESULTS: Fifty-two patients (age 63 +/- 9 years, EF 24 +/- 8%) were randomized, 26 each to ablation and rate control. At 12 months, 88% of ablation patients maintained sinus rhythm (single-procedure success 68%). Under rate control, rate criteria were achieved in 96%. The primary endpoint, peak oxygen consumption, significantly increased in the ablation arm compared with rate control (difference +3.07 ml/kg/min, 95% confidence interval: 0.56 to 5.59, p = 0.018). The change was not evident at 3 months (+0.79 ml/kg/min, 95% confidence interval: -1.01 to 2.60, p = 0.38). Ablation improved Minnesota score (p = 0.019) and B-type natriuretic peptide (p = 0.045) and showed nonsignificant trends toward improved 6-min walk distance (p = 0.095) and EF (p = 0.055). CONCLUSIONS: This first randomized trial of ablation versus rate control to focus on objective exercise performance in AF and HF shows significant benefit from ablation, a strategy that also improves symptoms and neurohormonal status. The effects develop over 12 months, consistent with progressive amelioration of the HF syndrome. (A Randomised Trial to Assess Cat

Journal article

Jones DG, Haldar SK, Sharma R, Rahman-Haley SL, Francis DP, McDonagh TA, Mattar W, Underwood R, Hussain W, Markides V, Wong Tet al., 2012, A Randomised Trial to Assess Catheter Ablation versus Rate Control in the Management of Persistent Atrial Fibrillation in Chronic Heart Failure, Scientific Sessions of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 2788-2788, ISSN: 0009-7322

Conference paper

Mantziari L, Guha K, Khalique Z, McDonagh T, Sharma Ret al., 2012, Relation of Dosing of the Renin-Angiotensin System Inhibitors After Cardiac Resynchronization Therapy to Long-Term Prognosis, AMERICAN JOURNAL OF CARDIOLOGY, Vol: 109, Pages: 1619-1625, ISSN: 0002-9149

Journal article

Pryse-Hawkins H, Davidson L, Fallon L, Guha K, Lyon AR, Sharma R, Vazir A, Cowie MRet al., 2012, AUDIT OF TERTIARY HEART FAILURE OUTPATIENT SERVICE TO ASSESS COMPLIANCE WITH UPDATED NICE GUIDELINES, Annual Conference of the British-Cardiovascular-Society (BCS), Publisher: B M J PUBLISHING GROUP, Pages: A10-A11, ISSN: 1355-6037

Conference paper

Alpendurada F, Guha K, Sharma R, Ismail TF, Clifford A, Banya W, Mohiaddin RH, Pennell DJ, Cowie MR, McDonagh T, Prasad SKet al., 2011, Right ventricular dysfunction is a predictor of non-response and clinical outcome following cardiac resynchronization therapy, JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, Vol: 13, ISSN: 1097-6647

Journal article

Guha K, Alpendurada F, Prasad SK, Cowie MR, Mohiaddin R, Mcdonagh T, Sharma Ret al., 2011, Right ventricular dysfunction predicts clinical outcomes for patients following the implantation of cardiac resynchronisation therapy, EUROPEAN HEART JOURNAL, Vol: 32, Pages: 286-286, ISSN: 0195-668X

Journal article

Guha K, Alpendurada F, Prasad S, McDonagh T, Cowie MR, Sharma Ret al., 2011, RIGHT VENTRICULAR DYSFUNCTION IDENTIFIES CLINICAL OUTCOMES FOLLOWING CARDIAC RESYNCHRONISATION THERAPY, Annual Conference of the British-Cardiovascular-Society (BCS), Publisher: B M J PUBLISHING GROUP, Pages: A53-A53, ISSN: 1355-6037

Conference paper

Dubrey SW, Mehta PA, Sharma R, Shah Set al., 2011, Entitlement to hospital treatment in the UK, BRITISH JOURNAL OF HOSPITAL MEDICINE, Vol: 72, Pages: 294-294, ISSN: 1750-8460

Journal article

Chandrasekaran B, Sharma R, Donovan J, Stirrup J, Wechalekar K, Hooper J, Underwood SR, Cowie MR, Mcdonagh Tet al., 2009, The effect of cardiac resynchronisation therapy on plasma apelin, EUROPEAN HEART JOURNAL, Vol: 30, Pages: 135-136, ISSN: 0195-668X

Journal article

Sharma R, Zucknick M, London R, Kacevska M, Liddle C, Clarke SJet al., 2008, Systemic inflammatory response predicts prognosis in patients with advanced-stage colorectal cancer, CLINICAL COLORECTAL CANCER, Vol: 7, Pages: 331-337, ISSN: 1533-0028

Journal article

Chandrasekaran B, Sharma R, Stirrup J, Dar O, Wechalekar K, Clague J, Underwood SR, Cowie MR, McDonagh Tet al., 2008, Left ventricular remodelling after cardiac resynchronisation therapy in a contemporary heart failure population, Annual Scientific Conference of the British-Cardiovascular-Society/British-Society-for-Cardiovascular-Research, Publisher: B M J PUBLISHING GROUP, Pages: A105-A106, ISSN: 1355-6037

Conference paper

Krack A, Sharma R, Figulla HR, Anker SDet al., 2005, The importance of the gastrointestinal system in the pathogenesis of heart failure, EUROPEAN HEART JOURNAL, Vol: 26, Pages: 2368-2374, ISSN: 0195-668X

Journal article

Sharma R, Bolger AP, Rauchhaus M, von Haehling S, Doehner W, Adcock IM, Barnes PJ, Poole-Wilson PA, Volk HD, Coats AJS, Lim S, Anker SDet al., 2005, Cellular endotoxin desensitization in patients with severe chronic heart failure, EUROPEAN JOURNAL OF HEART FAILURE, Vol: 7, Pages: 865-868, ISSN: 1388-9842

Journal article

Iqbal MB, Sharma R, Underwood SR, Kaddoura Set al., 2005, Radioisotopes and airport security, LANCET, Vol: 366, Pages: 342-342, ISSN: 0140-6736

Journal article

Sharma R, von Haehling S, Rauchhaus M, Bolger AP, Genth-Zotz S, Doehner W, Oliver B, Poole-Wilson PA, Volk HD, Coats AJS, Adcock IM, Anker SDet al., 2005, Whole blood endotoxin responsiveness in patients with chronic heart failure: the importance of serum lipoproteins, EUROPEAN JOURNAL OF HEART FAILURE, Vol: 7, Pages: 479-484, ISSN: 1388-9842

Journal article

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