Publications
71 results found
Dubrey S, Shah S, Hardman T, et al., 2014, Sarcoidosis: the links between epidemiology and aetiology, POSTGRADUATE MEDICAL JOURNAL, Vol: 90, Pages: 582-589, ISSN: 0032-5473
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- Citations: 43
Arnold AD, Kouranos V, Wechalekar K, et al., 2014, Immunosuppressive therapy and upgrade of conventional pacemaker to CRT-D for dilated cardiomyopathy due to cardiac sarcoidosis, with discordance of disease activity between PET-CT and CMR, Annual Meeting of the European-Society-of-Cardiology (ESC), Publisher: OXFORD UNIV PRESS, Pages: 1205-1205, ISSN: 0195-668X
Theron P, Guha K, Mantziari L, et al., 2014, General Anesthesia Versus Sedation for Implantation of a Biventricular Pacing Device for Cardiac Resynchronization Therapy, JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA, Vol: 28, Pages: 280-284, ISSN: 1053-0770
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- Citations: 5
Guha K, Konstantinou D, Mantziari L, et al., 2014, The impact of age on clinical outcomes following cardiac resynchronisation therapy, JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY, Vol: 39, Pages: 95-102, ISSN: 1383-875X
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- Citations: 3
Gulati A, Ismail TF, Jabbour A, et al., 2013, The Prevalence and Prognostic Significance of Right Ventricular Systolic Dysfunction in Nonischemic Dilated Cardiomyopathy, CIRCULATION, Vol: 128, Pages: 1623-1633, ISSN: 0009-7322
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- Citations: 203
Guha K, Mantziari L, Sharma R, et al., 2013, A reduction in total isovolumic time with cardiac resynchronisation therapy is a predictor of clinical outcomes, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 168, Pages: 382-387, ISSN: 0167-5273
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- Citations: 6
Konstantinou D, Guha K, Cook C, et al., 2013, QRS duration and clinical outcomes in heart failure patients receiving cardiac resynchronization therapy, Congress of the European-Society-of-Cardiology (ESC), Publisher: OXFORD UNIV PRESS, Pages: 585-585, ISSN: 0195-668X
Guha K, Treibel TA, Roussin I, et al., 2013, Treatment of left ventricular non-compaction with cardiac resynchronization therapy, QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, Vol: 106, Pages: 575-579, ISSN: 1460-2725
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- Citations: 2
Richardson JA, Hayward C, Khanna A, et al., 2013, Predictive value of future ventricular arrhythmic risk in patients with chronic heart failure from annual remote telemonitoring, EUROPEAN JOURNAL OF HEART FAILURE, Vol: 12, Pages: S247-S247, ISSN: 1388-9842
Simpkin VL, Tavazzi G, Ludman A, et al., 2013, Serial central venous saturations during ultrafiltration can predict acute kidney injury in acutely decompensated heart failure patients, EUROPEAN JOURNAL OF HEART FAILURE, Vol: 12, Pages: S286-S286, ISSN: 1388-9842
Honarbakhsh S, Simpkin VL, Griffiths MR, et al., 2013, Survival and characteristics of patients undergoing rescue cardiac resynchronisation therapy in cardiac intensive care, EUROPEAN JOURNAL OF HEART FAILURE, Vol: 12, Pages: S294-S294, ISSN: 1388-9842
Guha K, Morley-Smith A, Savage HO, et al., 2013, The effect of upgrade from dual chamber ICD to Cardiac resynchronisation therapy and defibrillator upon ventricular arrhythmia burden, EUROPEAN JOURNAL OF HEART FAILURE, Vol: 12, Pages: S301-S302, ISSN: 1388-9842
Demir OM, Darragh K, Pakrashi T, et al., 2013, Integrating the management of elevated resting heart rate in a specialist tertiary centre heart failure clinic, EUROPEAN JOURNAL OF HEART FAILURE, Vol: 12, Pages: S202-S202, ISSN: 1388-9842
Shah G, Scadding G, Nguyen-Lu N, et al., 2013, Peri-operative cardiac arrest with ST elevation secondary to gelofusin anaphylaxis - Kounis syndrome in the anaesthetic room, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 164, Pages: E22-E26, ISSN: 0167-5273
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- Citations: 20
Mantziari L, Guha K, Senguttuvan NB, et al., 2013, Cardiac resynchronization therapy for critically ill patients with left ventricular systolic dysfunction, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 163, Pages: 141-145, ISSN: 0167-5273
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- Citations: 7
Jones DG, Haldar SK, Hussain W, et al., 2013, A randomized trial to assess catheter ablation versus rate control in the management of persistent atrial fibrillation in heart failure, J Am Coll Cardiol, Vol: 61, Pages: 1894-1903, ISSN: 1558-3597
OBJECTIVES: This study sought to compare catheter ablation with rate control for persistent atrial fibrillation (AF) in heart failure (HF). BACKGROUND: The optimal therapy for AF in HF is unclear. Drug-based rhythm control has not proved clinically beneficial. Catheter ablation improves cardiac function in patients with HF, but impact on physiological performance has not been formally evaluated in a randomized trial. METHODS: In a randomized, open-label, blinded-endpoint clinical trial, adults with symptomatic HF, radionuclide left ventricular ejection fraction (EF) </=35%, and persistent AF were assigned to undergo catheter ablation or rate control. Primary outcome was 12-month change in peak oxygen consumption. Secondary endpoints were quality of life, B-type natriuretic peptide, 6-min walk distance, and EF. Results were analyzed by intention-to-treat. RESULTS: Fifty-two patients (age 63 +/- 9 years, EF 24 +/- 8%) were randomized, 26 each to ablation and rate control. At 12 months, 88% of ablation patients maintained sinus rhythm (single-procedure success 68%). Under rate control, rate criteria were achieved in 96%. The primary endpoint, peak oxygen consumption, significantly increased in the ablation arm compared with rate control (difference +3.07 ml/kg/min, 95% confidence interval: 0.56 to 5.59, p = 0.018). The change was not evident at 3 months (+0.79 ml/kg/min, 95% confidence interval: -1.01 to 2.60, p = 0.38). Ablation improved Minnesota score (p = 0.019) and B-type natriuretic peptide (p = 0.045) and showed nonsignificant trends toward improved 6-min walk distance (p = 0.095) and EF (p = 0.055). CONCLUSIONS: This first randomized trial of ablation versus rate control to focus on objective exercise performance in AF and HF shows significant benefit from ablation, a strategy that also improves symptoms and neurohormonal status. The effects develop over 12 months, consistent with progressive amelioration of the HF syndrome. (A Randomised Trial to Assess Cat
Jones DG, Haldar SK, Sharma R, et al., 2012, A Randomised Trial to Assess Catheter Ablation versus Rate Control in the Management of Persistent Atrial Fibrillation in Chronic Heart Failure, Scientific Sessions of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 2788-2788, ISSN: 0009-7322
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- Citations: 2
Mantziari L, Guha K, Khalique Z, et al., 2012, Relation of Dosing of the Renin-Angiotensin System Inhibitors After Cardiac Resynchronization Therapy to Long-Term Prognosis, AMERICAN JOURNAL OF CARDIOLOGY, Vol: 109, Pages: 1619-1625, ISSN: 0002-9149
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- Citations: 11
Pryse-Hawkins H, Davidson L, Fallon L, et al., 2012, AUDIT OF TERTIARY HEART FAILURE OUTPATIENT SERVICE TO ASSESS COMPLIANCE WITH UPDATED NICE GUIDELINES, Annual Conference of the British-Cardiovascular-Society (BCS), Publisher: B M J PUBLISHING GROUP, Pages: A10-A11, ISSN: 1355-6037
Alpendurada F, Guha K, Sharma R, et al., 2011, Right ventricular dysfunction is a predictor of non-response and clinical outcome following cardiac resynchronization therapy, JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, Vol: 13, ISSN: 1097-6647
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- Citations: 38
Guha K, Alpendurada F, Prasad SK, et al., 2011, Right ventricular dysfunction predicts clinical outcomes for patients following the implantation of cardiac resynchronisation therapy, EUROPEAN HEART JOURNAL, Vol: 32, Pages: 286-286, ISSN: 0195-668X
Guha K, Alpendurada F, Prasad S, et al., 2011, RIGHT VENTRICULAR DYSFUNCTION IDENTIFIES CLINICAL OUTCOMES FOLLOWING CARDIAC RESYNCHRONISATION THERAPY, Annual Conference of the British-Cardiovascular-Society (BCS), Publisher: B M J PUBLISHING GROUP, Pages: A53-A53, ISSN: 1355-6037
Dubrey SW, Mehta PA, Sharma R, et al., 2011, Entitlement to hospital treatment in the UK, BRITISH JOURNAL OF HOSPITAL MEDICINE, Vol: 72, Pages: 294-294, ISSN: 1750-8460
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- Citations: 1
Chandrasekaran B, Sharma R, Donovan J, et al., 2009, The effect of cardiac resynchronisation therapy on plasma apelin, EUROPEAN HEART JOURNAL, Vol: 30, Pages: 135-136, ISSN: 0195-668X
Sharma R, Zucknick M, London R, et al., 2008, Systemic inflammatory response predicts prognosis in patients with advanced-stage colorectal cancer, CLINICAL COLORECTAL CANCER, Vol: 7, Pages: 331-337, ISSN: 1533-0028
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- Citations: 87
Chandrasekaran B, Sharma R, Stirrup J, et al., 2008, Left ventricular remodelling after cardiac resynchronisation therapy in a contemporary heart failure population, Annual Scientific Conference of the British-Cardiovascular-Society/British-Society-for-Cardiovascular-Research, Publisher: B M J PUBLISHING GROUP, Pages: A105-A106, ISSN: 1355-6037
Krack A, Sharma R, Figulla HR, et al., 2005, The importance of the gastrointestinal system in the pathogenesis of heart failure, EUROPEAN HEART JOURNAL, Vol: 26, Pages: 2368-2374, ISSN: 0195-668X
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- Citations: 185
Sharma R, Bolger AP, Rauchhaus M, et al., 2005, Cellular endotoxin desensitization in patients with severe chronic heart failure, EUROPEAN JOURNAL OF HEART FAILURE, Vol: 7, Pages: 865-868, ISSN: 1388-9842
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- Citations: 20
Iqbal MB, Sharma R, Underwood SR, et al., 2005, Radioisotopes and airport security, LANCET, Vol: 366, Pages: 342-342, ISSN: 0140-6736
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- Citations: 13
Sharma R, von Haehling S, Rauchhaus M, et al., 2005, Whole blood endotoxin responsiveness in patients with chronic heart failure: the importance of serum lipoproteins, EUROPEAN JOURNAL OF HEART FAILURE, Vol: 7, Pages: 479-484, ISSN: 1388-9842
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- Citations: 39
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