Dr Ravi Singh is currently based at the Molecular Sciences Research Hub (White City campus) in the group of Professor Ed Tate. Ravi's role involves managing the Tate laboratory, conducting small molecule synthesis, acting as the cohort manager for the MRes in Drug Discovery and Development (DDD) course, directly supervising several MRes DDD students on reseach projects, and teaching and assessing within the MRes DDD programme.
Ravi is also involved in undergraduate chemistry teaching: both as a staff demonstrator in the teaching labs and an organic chemistry tutor. At third year, Ravi is a co-supervisor for BSc research projects.
Ravi obtained his degree in Medicinal Chemistry (MChem, BSc) from the University of Leeds, with his MChem research project focusing on disrupting protein-protein interactions implicated in cancer. This was achieved using a combination of small molecules and constrained peptides. Ravi then remained at the University of Leeds to complete an interdisciplinary PhD which involved working in the Department of Chemistry, Leeds Institute of Cardiology and Metabolic Medicine (LICAMM), and The Astbury Centre for Structural and Molecular Biology. This research project aimed to identify and optimize novel small molecules against a confidential target implicated in thrombosis. The project utilized a combination of in silico modelling, organic synthesis, and biochemical testing. Colleagues at LICAMM designed and developed an in vitro chromogenic assay which was used to generate potency and selectivity data of the synthesized molecules. Ravi then initiated an NMR fragment screening process (The Astbury Centre) to generate hits for a new series against the biological target of interest.
Dr Singh also has a strong interest in Chemical Education. During his PhD, he designed and developed online tools which were used in undergraduate lectures and then published in the Journal of Chemical Education. Ravi also blended his PhD research with the undergraduate teaching laboratories by creating a series of workshops. This allowed students to apply their theoretical knowledge in a ‘real world’ setting in a classroom-based activity, which resulted in another publication in the Journal of Chemical Education. Ravi was then awarded his Associate Fellowship of the Advance HE in August 2018 and was invited to speak at ViCEPhEC 2018 held at the University of Sheffield. In 2022, Ravi was awarded his Fellowship from Advance HE.
Research interests: organic synthesis, medicinal chemistry, chemical education, computational modelling, protein-ligand NMR, fragment-based drug discovery, chemical biology.
et al., 2021, A probe for NLRP3 inflammasome inhibitor MCC950 identifies carbonic anhydrase 2 as a novel target, Acs Chemical Biology, Vol:16, ISSN:1554-8929, Pages:982-990
et al., 2021, A Classroom-Based Activity to Teach Students How to Apply Organic Chemistry Theory to Design Experiments, Journal of Chemical Education, Vol:98, ISSN:0021-9584, Pages:515-520
Mistry N, Singh R, Ridley J, 2020, A Web-Based Stereochemistry Tool to Improve Students' Ability to Draw Newman Projections and Chair Conformations and Assign R/S Labels, Journal of Chemical Education, Vol:97, ISSN:0021-9584, Pages:1157-1161