Imperial College London
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DrRichardAbel

Faculty of Medicine, Department of Surgery & Cancer

Senior Lecturer
 
 
 
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richard.abel

 
 
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Location

 

204Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Langley:2015:10.1016/j.eururo.2015.11.030,
author = {Langley, RE and Kynaston, HG and Alhasso, AA and Duong, T and Paez, EM and Jovic, G and Scrase, CD and Robertson, A and Cafferty, F and Welland, A and Carpenter, R and Honeyfield, L and Abel, RL and Stone, M and Parmar, MK and Abel, PD},
doi = {10.1016/j.eururo.2015.11.030},
journal = {European Urology},
pages = {1016--1025},
title = {A randomised comparison evaluating changes in bone mineral density in advanced prostate cancer: luteinising hormone-releasing hormone agonists versus transdermal oestradiol.},
url = {http://dx.doi.org/10.1016/j.eururo.2015.11.030},
volume = {69},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Luteinising hormone-releasing hormone agonists (LHRHa), used as androgen deprivation therapy (ADT) in prostate cancer (PCa) management, reduce serum oestradiol as well as testosterone, causing bone mineral density (BMD) loss. Transdermal oestradiol is a potential alternative to LHRHa. OBJECTIVE: To compare BMD change in men receiving either LHRHa or oestradiol patches (OP). DESIGN, SETTING, AND PARTICIPANTS: Men with locally advanced or metastatic PCa participating in the randomised UK Prostate Adenocarcinoma TransCutaneous Hormones (PATCH) trial (allocation ratio of 1:2 for LHRHa:OP, 2006-2011; 1:1, thereafter) were recruited into a BMD study (2006-2012). Dual-energy x-ray absorptiometry scans were performed at baseline, 1 yr, and 2 yr. INTERVENTIONS: LHRHa as per local practice, OP (FemSeven 100μg/24h patches). OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: The primary outcome was 1-yr change in lumbar spine (LS) BMD from baseline compared between randomised arms using analysis of covariance. RESULTS AND LIMITATIONS: A total of 74 eligible men (LHRHa 28, OP 46) participated from seven centres. Baseline clinical characteristics and 3-mo castration rates (testosterone ≤1.7 nmol/l, LHRHa 96% [26 of 27], OP 96% [43 of 45]) were similar between arms. Mean 1-yr change in LS BMD was -0.021g/cm(3) for patients randomised to the LHRHa arm (mean percentage change -1.4%) and +0.069g/cm(3) for the OP arm (+6.0%; p<0.001). Similar patterns were seen in hip and total body measurements. The largest difference between arms was at 2 yr for those remaining on allocated treatment only: LS BMD mean percentage change LHRHa -3.0% and OP +7.9% (p<0.001). CONCLUSIONS: Transdermal oestradiol as a single agent produces castration levels of testosterone while mitigating BMD loss. These early data provide further supporting evidence for the ongoing phase 3 trial. PATIENT SUMMARY: This study found that prostate cancer patients treated with transdermal oestradiol for ho
AU  - Langley,RE
AU  - Kynaston,HG
AU  - Alhasso,AA
AU  - Duong,T
AU  - Paez,EM
AU  - Jovic,G
AU  - Scrase,CD
AU  - Robertson,A
AU  - Cafferty,F
AU  - Welland,A
AU  - Carpenter,R
AU  - Honeyfield,L
AU  - Abel,RL
AU  - Stone,M
AU  - Parmar,MK
AU  - Abel,PD
DO  - 10.1016/j.eururo.2015.11.030
EP  - 1025
PY  - 2015///
SN  - 1421-993X
SP  - 1016
TI  - A randomised comparison evaluating changes in bone mineral density in advanced prostate cancer: luteinising hormone-releasing hormone agonists versus transdermal oestradiol.
T2  - European Urology
UR  - http://dx.doi.org/10.1016/j.eururo.2015.11.030
UR  - http://www.ncbi.nlm.nih.gov/pubmed/26707868
UR  - http://hdl.handle.net/10044/1/30344
VL  - 69
ER  -
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