Imperial College London
Portrait Picture

Dr Richard J Hewitt

Faculty of Medicine, National Heart & Lung Institute

Honorary Clinical Senior Lecturer
 
 
 
//

Contact

 

+44 (0)7731 574 288richard.hewitt

 
 
//

Location

 

Desk 24Sir Alexander Fleming BuildingSouth Kensington Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Hewitt:2016:10.1177/1753465815618113,
author = {Hewitt, R and Farne, H and Ritchie, A and Luke, E and Johnston, SL and Mallia, P},
doi = {10.1177/1753465815618113},
journal = {Therapeutic Advances in Respiratory Disease},
pages = {158--174},
title = {The role of viral infections in exacerbations of chronic obstructive pulmonary disease and asthma},
url = {http://dx.doi.org/10.1177/1753465815618113},
volume = {10},
year = {2016}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Asthma and chronic obstructive pulmonary disease (COPD) are major causes of global morbidity and mortality worldwide. The clinical course of both asthma and COPD are punctuated by the occurrence of exacerbations, acute events characterized by increased symptoms and airflow obstruction. Exacerbations contribute most of the morbidity, mortality and excess healthcare costs associated with both asthma and COPD. COPD and asthma exacerbations are frequently associated with respiratory virus infections and this has led to an intense research focus into the mechanisms of virus-induced exacerbations over the past decade. Current therapies are effective in reducing chronic symptoms but are less effective in preventing exacerbations, particularly in COPD. Understanding the mechanisms of virus-induced exacerbation will lead to the development of new targeted therapies that can reduce the burden of virus-induced exacerbations. In this review we discuss current knowledge of virus-induced exacerbations of asthma and COPD with a particular focus on mechanisms, human studies, virus–bacteria interactions and therapeutic advances.
AU  - Hewitt,R
AU  - Farne,H
AU  - Ritchie,A
AU  - Luke,E
AU  - Johnston,SL
AU  - Mallia,P
DO  - 10.1177/1753465815618113
EP  - 174
PY  - 2016///
SN  - 1753-4666
SP  - 158
TI  - The role of viral infections in exacerbations of chronic obstructive pulmonary disease and asthma
T2  - Therapeutic Advances in Respiratory Disease
UR  - http://dx.doi.org/10.1177/1753465815618113
VL  - 10
ER  -
Download