Publications
156 results found
Little CD, Kotecha T, Candilio L, et al., 2020, COVID-19 pandemic and STEMI: pathway activation and outcomes from the pan-London heart attack group, OPEN HEART, Vol: 7, ISSN: 2053-3624
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- Citations: 20
Tanaka A, Jabbour RJ, Colombo A, 2019, What are the remaining lessons to be learnt from 1st-generation bioresorbable scaffolds?, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 293, Pages: 103-104, ISSN: 0167-5273
Handa BS, Li X, Mansfield CA, et al., 2019, Ventricular fibrosis spatial distribution and quantity is a key mechanistic determinant of ventricular fibrillation mechanisms, Congress of the European-Society-of-Cardiology (ESC) / World Congress of Cardiology, Publisher: OXFORD UNIV PRESS, Pages: 896-896, ISSN: 0195-668X
Jabbour R, Owen T, Reinsch M, et al., 2019, Development and preclinical testing of upscaled engineered heart tissue for use in translational studies, Congress of the European-Society-of-Cardiology (ESC) / World Congress of Cardiology, Publisher: OXFORD UNIV PRESS, Pages: 3273-3273, ISSN: 0195-668X
Harding S, Jabbour R, 2019, Tissue engineering for cardiovascular repair, Annual Conference of the British-Society-for-Gene-and-Cell-Therapy, Publisher: MARY ANN LIEBERT, INC, Pages: A8-A8, ISSN: 1043-0342
Jabbour RJ, Latib A, 2019, The changing landscape of interventional cardiology, AGING-US, Vol: 11, Pages: 2914-2915, ISSN: 1945-4589
Watson S, Duff J, Bardi I, et al., 2019, Biomimetic electromechanical stimulation to maintain adult myocardial slices in vitro, Nature Communications, Vol: 10, ISSN: 2041-1723
Adult cardiac tissue undergoes a rapid process of dedifferentiation when cultured outside the body. The in vivo environment, particularly constant electromechanical stimulation, is fundamental to the regulation of cardiac structure and function. We investigated the role of electromechanical stimulation in preventing culture-induced dedifferentiation of adult cardiac tissue using rat, rabbit and human heart failure myocardial slices. Here we report that the application of a preload equivalent to sarcomere length (SL) = 2.2 μm is optimal for the maintenance of rat myocardial slice structural, functional and transcriptional properties at 24 h. Gene sets associated with the preservation of structure and function are activated, while gene sets involved in dedifferentiation are suppressed. The maximum contractility of human heart failure myocardial slices at 24 h is also optimally maintained at SL = 2.2 μm. Rabbit myocardial slices cultured at SL = 2.2 μm remain stable for 5 days. This approach substantially prolongs the culture of adult cardiac tissue in vitro.
Handa B, Li X, Mansfield C, et al., 2019, MYOCARDIAL FIBROSIS AND THE DEGREE OF GAP JUNCTION COUPLING DIRECTLY MODIFIES THE UNDERLYING MECHANISM OF FIBRILLATION, Annual Conference of the British-Cardiovascular-Society (BCS) - Digital Health Revolution, Publisher: BMJ PUBLISHING GROUP, Pages: A179-A180, ISSN: 1355-6037
Tanaka A, Jabbour RJ, Testa L, et al., 2019, Incidence, Technical Safety, and Feasibility of Coronary Angiography and Intervention Following Self-expanding Transcatheter Aortic Valve Replacement, CARDIOVASCULAR REVASCULARIZATION MEDICINE, Vol: 20, Pages: 371-375, ISSN: 1553-8389
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- Citations: 24
Jabbour R, Owen T, Reinsch M, et al., 2019, DEVELOPMENT AND PRECLINICAL TESTING OF A LARGE HEART MUSCLE PATCH, Annual Conference of the British-Cardiovascular-Society (BCS) - Digital Health Revolution, Publisher: BMJ PUBLISHING GROUP, Pages: A157-A158, ISSN: 1355-6037
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- Citations: 3
Montalto C, Mangieri A, Jabbour RJ, et al., 2019, Prevalence, Burden and Echocardiographic Features of Moderate to Severe Tricuspid Regurgitation: Insights from a Tertiary Referral Center, STRUCTURAL HEART-THE JOURNAL OF THE HEART TEAM, Vol: 3, Pages: 123-131, ISSN: 2474-8706
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- Citations: 7
Jabbour RJ, Mikhail GW, 2019, Valve durability - is this the Achilles' heel of TAVI?, EUROINTERVENTION, Vol: 14, Pages: E1544-E1547, ISSN: 1774-024X
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- Citations: 3
Yazdani KO, Mitomo S, Ruparelia N, et al., 2019, Percutaneous left atrial appendage occlusion with the Amulet device: The impact of device disc position upon periprocedural and long-term outcomes, CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, Vol: 93, Pages: 120-127, ISSN: 1522-1946
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- Citations: 6
Jabbour RJ, Latib A, 2019, The "new" syndrome of delayed coronary obstruction after transcatheter aortic valve replacement, CARDIOVASCULAR REVASCULARIZATION MEDICINE, Vol: 20, Pages: 81-83, ISSN: 1553-8389
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- Citations: 1
Mitomo S, Jabbour RJ, Latib A, et al., 2018, Bioresorbable vascular scaffold implantation for severely calcified lesions after excimer laser lesion preparation, CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, Vol: 92, Pages: 1283-1288, ISSN: 1522-1946
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- Citations: 1
Mitomo S, Latib A, Jabbour RJ, et al., 2018, Variation in vessel healing response after implantation of two different poly-L-lactic acid bioresorbable scaffolds: insights from optical coherence tomography, EUROINTERVENTION, Vol: 14, Pages: E1304-E1305, ISSN: 1774-024X
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- Citations: 1
Zhou Y, Chen S, Huang L, et al., 2018, Definite stent thrombosis after drug-eluting stent implantation in coronary bifurcation lesions: A meta-analysis of 3,107 patients from 14 randomized trials, CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, Vol: 92, Pages: 680-691, ISSN: 1522-1946
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- Citations: 9
Jabbour RJ, Tanaka A, Colombo A, et al., 2018, Delayed Coronary Occlusion After Transcatheter Aortic Valve Implantation: Implications for New Transcatheter Heart Valve Design and Patient Management., Interv Cardiol, Vol: 13, Pages: 137-139
Transcatheter aortic valve implantation has revolutionised the treatment of patients with severe aortic stenosis and is the preferred treatment option for patients with elevated surgical risk. Outcomes have continually improved, but because of the nature of the procedure infrequent catastrophic complications, such as coronary obstruction, persist. Recently, data were published regarding delayed coronary obstruction (DCO), a phenomenon in which the obstruction occurs after the index procedure. DCO has important consequences for future research. In this article we will explore the implications for new transcatheter heart valve design and approaches to patient management to minimise the risk of DCO occurring.
Mangieri A, Lanzillo G, Bertoldi L, et al., 2018, Predictors of Advanced Conduction Disturbances Requiring a Late (≥48 H) Permanent Pacemaker Following Transcatheter Aortic Valve Replacement, JACC-CARDIOVASCULAR INTERVENTIONS, Vol: 11, Pages: 1519-1526, ISSN: 1936-8798
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- Citations: 66
Watson SA, Duff JD, Bardi IB, et al., 2018, A novel platform to maintain adult cardiac tissue in vitro: myocardial slices and electromechanical stimulation with physiological preload, European-Society-of-Cardiology Congress, Publisher: OXFORD UNIV PRESS, Pages: 1090-1090, ISSN: 0195-668X
Jabbour R, Kapnisi K, Mawad D, et al., 2018, Conductive polymers affect myocardial conduction velocity but are not pro-arrhythmic, European-Society-of-Cardiology Congress, Publisher: OXFORD UNIV PRESS, Pages: 1205-1205, ISSN: 0195-668X
Mitomo S, Jabbour RJ, Mangieri A, et al., 2018, Mid-term clinical outcomes after bailout drug-eluting stenting for suboptimal drug-coated balloon results: Insights from a Milan registry, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 263, Pages: 17-23, ISSN: 0167-5273
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- Citations: 13
Kawamoto H, Chieffo A, D'Ascenzo F, et al., 2018, Provisional versus elective two-stent strategy for unprotected true left main bifurcation lesions: Insights from a FAILS-2 sub-study (vol 250, pg 80, 2018), INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 263, Pages: 188-188, ISSN: 0167-5273
Giannini F, Baldetti L, Ponticelli F, et al., 2018, Coronary Sinus Reducer Implantation for the Treatment of Chronic Refractory Angina A Single-Center Experience, JACC-CARDIOVASCULAR INTERVENTIONS, Vol: 11, Pages: 784-792, ISSN: 1936-8798
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- Citations: 36
Jabbour RJ, Tanaka A, Finkelstein A, et al., 2018, Delayed Coronary Obstruction After Transcatheter Aortic Valve Replacement, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 71, Pages: 1513-1524, ISSN: 0735-1097
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- Citations: 118
Giannini F, Latib A, Montorfano M, et al., 2018, A comparison of the fully repositionable and retrievable Boston Lotus and direct flow medical valves for the treatment of severe aortic stenosis: A single center experience, CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, Vol: 91, Pages: 966-974, ISSN: 1522-1946
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- Citations: 4
Mitomo S, Jabbour RJ, Watanabe Y, et al., 2018, Comparison of mid-term clinical outcomes after treatment of ostial right coronary artery lesions with early and new generation drug-eluting stents: Insights from an international multicenter registry, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 254, Pages: 53-58, ISSN: 0167-5273
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- Citations: 8
Ahmad Y, Demir O, Rajkumar CA, et al., 2018, Optimal antiplatelet strategy after transcatheter aortic valve implantation: a meta-analysis, Open Heart, Vol: 5, ISSN: 2053-3624
Objective International guidelines recommend the use of dual antiplatelet therapy (DAPT) after transcatheter aortic valve implantation (TAVI). The recommended duration of DAPT varies between guidelines. In this two-part study, we (1) performed a structured survey of 45 TAVI centres from around the world to determine if there is consensus among clinicians regarding antiplatelet therapy after TAVI; and then (2) performed a systematic review of all suitable studies (randomised controlled trials (RCTs) and registries) to determine if aspirin monotherapy can be used instead of DAPT.Methods A structured electronic survey regarding antiplatelet use after TAVI was completed by 45 TAVI centres across Europe, Australasia and the USA. A systematic review of TAVI RCTs and registries was then performed comparing DAPT duration and incidence of stroke, bleeding and death. A variance weighted least squared metaregression was then performed to determine the relationship of antiplatelet therapy and adverse events.Results 82.2% of centres routinely used DAPT after TAVI. Median duration was 3 months. 13.3% based their practice on guidelines. 11 781 patients (26 studies) were eligible for the metaregression. There was no benefit of DAPT over aspirin monotherapy for stroke (P=0.49), death (P=0.72) or bleeding (P=0.91).Discussion Aspirin monotherapy appears to be as safe and effective as DAPT after TAVI.
Mangieri A, Montorfano M, Stella S, et al., 2018, Severe Mitral Stenosis and Persistent Left Appendage Thrombosis When an Old Percutaneous Solution Meets New Percutaneous Strategies, JACC-CARDIOVASCULAR INTERVENTIONS, Vol: 11, Pages: E11-E13, ISSN: 1936-8798
Kawamoto H, Chieffo A, D'Ascenzo F, et al., 2018, Provisional versus elective two- stent strategy for unprotected true left main bifurcation lesions: Insights from a FAILS-2 sub-study, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 250, Pages: 80-85, ISSN: 0167-5273
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- Citations: 13
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