Imperial College London
Alternate

Alex Bottle

Faculty of Medicine, School of Public Health

Professor of Medical Statistics
 
 
 
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Contact

 

+44 (0)20 7594 0913robert.bottle Website

 
 
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Location

 

3 Dorset Rise, London EC4Y 8ENCharing Cross HospitalCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Blackwell:2021:ecco-jcc/jjaa146,
author = {Blackwell, J and Saxena, S and Jayasooriya, N and Bottle, A and Petersen, I and Hotopf, M and Alexakis, C and Pollok, RC},
doi = {ecco-jcc/jjaa146},
journal = {Journal of Crohn's and Colitis},
pages = {203--211},
title = {Prevalence and duration of gastrointestinal symptoms before diagnosis of Inflammatory Bowel Disease and predictors of timely specialist review: a population-based study},
url = {http://dx.doi.org/10.1093/ecco-jcc/jjaa146},
volume = {15},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background and AimsLack of timely referral and significant waits for specialist review amongst individuals with unresolved gastrointestinal (GI) symptoms can result in delayed diagnosis of Inflammatory Bowel Disease (IBD).AimsTo determine the frequency and duration of GI symptoms and predictors of timely specialist review before the diagnosis of both Crohn’s Disease (CD) and ulcerative colitis (UC).MethodsCase-control study of IBD matched 1:4 for age and sex to controls without IBD using the Clinical Practice Research Datalink from 1998-2016.ResultsWe identified 19,555 cases of IBD, and 78,114 controls. 1 in 4 cases of IBD reported gastrointestinal symptoms to their primary care physician more than 6 months before receiving a diagnosis. There is a significant excess prevalence of GI symptoms in each of the 10 years before IBD diagnosis. GI symptoms were reported by 9.6% and 10.4% at 5 years before CD and UC diagnosis respectively compared to 5.8% of controls. Amongst patients later diagnosed with IBD, <50% received specialist review within 18 months from presenting with chronic GI symptoms. Patients with a previous diagnosis of irritable bowel syndrome or depression were less likely to receive timely specialist review (IBS: HR=0.77, 95%CI 0.60-0.99, depression: HR=0.77, 95%CI 0.60-0.98).ConclusionsThere is an excess of GI symptoms 5 years before diagnosis of IBD compared to the background population which are likely attributable to undiagnosed disease. Previous diagnoses of IBS and depression are associated with delays in specialist review. Enhanced pathways are needed to accelerate specialist referral and timely IBD diagnosis.
AU  - Blackwell,J
AU  - Saxena,S
AU  - Jayasooriya,N
AU  - Bottle,A
AU  - Petersen,I
AU  - Hotopf,M
AU  - Alexakis,C
AU  - Pollok,RC
DO  - ecco-jcc/jjaa146
EP  - 211
PY  - 2021///
SN  - 1873-9946
SP  - 203
TI  - Prevalence and duration of gastrointestinal symptoms before diagnosis of Inflammatory Bowel Disease and predictors of timely specialist review: a population-based study
T2  - Journal of Crohn's and Colitis
UR  - http://dx.doi.org/10.1093/ecco-jcc/jjaa146
UR  - https://academic.oup.com/ecco-jcc/article/doi/10.1093/ecco-jcc/jjaa146/5871943
UR  - http://hdl.handle.net/10044/1/80785
VL  - 15
ER  -
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