Imperial College London
Alternate

Alex Bottle

Faculty of Medicine, School of Public Health

Professor of Medical Statistics
 
 
 
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Contact

 

+44 (0)20 7594 0913robert.bottle Website

 
 
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Location

 

3 Dorset Rise, London EC4Y 8ENCharing Cross HospitalCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bottle:2022:10.1136/openhrt-2021-001888,
author = {Bottle, R and Newson, R and Faitna, P and Hayhoe, B and Cowie, M},
doi = {10.1136/openhrt-2021-001888},
journal = {Open Heart},
title = {Changes in heart failure management and long-term mortality over ten years: observational study},
url = {http://dx.doi.org/10.1136/openhrt-2021-001888},
volume = {9},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Objectives: To estimate the long-term survival of two cohorts of people diagnosed with heart failure 10 years apart and to assess differences in patient characteristics, clinical guideline compliance and survival by diagnosis setting.Methods Data: for patients aged 18 and over with a new diagnosis of heart failure in the Clinical Practice Research Datalink in 2001–2002 (5966 patients in 156 practices) and 2011–2012 (12 827 patients in 331 practices). Survival rates since diagnosis were described using Kaplan-Meier plots. Compliance with national guidelines was summarised.Results: 2011/2012 patients were older than those diagnosed a decade before, with lower blood pressure and cholesterol but more comorbidity and healthcare contacts. For those diagnosed in 2001/2002, the 5-year survival was 40.0% (40.2% in the 2011/2012 cohort), 10-year survival was 20.8%, and 15-year survival 11.1%. Improvement in survival between the two time periods was seen only in those diagnosed in primary care (5-year survival 46.0% vs 57.4%, compared with 33.9% and 32.6% for hospital-diagnosed patients).Beta-blocker use rose from 24.3% to 39.1%; renin–angiotensin system blockers rose from 31.8% to 54.3% (both p<0.001). There was little change for loop diuretics and none for thiazide diuretics. For the 9963 patients with symptoms recorded by their general practitioner before diagnosis, brain natriuretic peptide (BNP) testing was low, but echocardiogram use rose from 8.3% to 19.3%, and specialist referral rose from 7.2% to 24.6% (all p<0.001).
AU  - Bottle,R
AU  - Newson,R
AU  - Faitna,P
AU  - Hayhoe,B
AU  - Cowie,M
DO  - 10.1136/openhrt-2021-001888
PY  - 2022///
SN  - 2053-3624
TI  - Changes in heart failure management and long-term mortality over ten years: observational study
T2  - Open Heart
UR  - http://dx.doi.org/10.1136/openhrt-2021-001888
UR  - http://hdl.handle.net/10044/1/96147
VL  - 9
ER  -
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