Publications
90 results found
De Oliveira EO, Wang K, Kong H-S, et al., 2011, Effect of the leukotriene A<sub>4</sub> hydrolase aminopeptidase augmentor 4-methoxydiphenylmethane in a pre-clinical model of pulmonary emphysema, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Vol: 21, Pages: 6746-6750, ISSN: 0960-894X
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- Citations: 17
Goulding J, Godlee A, Vekaria S, et al., 2011, Lowering the Threshold of Lung Innate Immune Cell Activation Alters Susceptibility to Secondary Bacterial Superinfection, JOURNAL OF INFECTIOUS DISEASES, Vol: 204, Pages: 1086-1094, ISSN: 0022-1899
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- Citations: 89
Snelgrove RJ, 2011, Targeting of a common receptor shared by CXCL8 and N-Ac-PGP as a therapeutic strategy to alleviate chronic neutrophilic lung diseases, EUROPEAN JOURNAL OF PHARMACOLOGY, Vol: 667, Pages: 1-5, ISSN: 0014-2999
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- Citations: 17
Snelgrove RJ, Godlee A, Hussell T, 2011, Airway immune homeostasis and implications for influenza-induced inflammation, TRENDS IN IMMUNOLOGY, Vol: 32, Pages: 328-334, ISSN: 1471-4906
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- Citations: 55
Snelgrove RJ, 2011, Leukotriene A<sub>4</sub> hydrolase: an anti-inflammatory role for a proinflammatory enzyme, THORAX, Vol: 66, Pages: 550-551, ISSN: 0040-6376
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- Citations: 32
Snelgrove RJ, Jackson PL, Hardison MT, et al., 2010, A Critical Role for LTA<sub>4</sub>H in Limiting Chronic Pulmonary Neutrophilic Inflammation, SCIENCE, Vol: 330, Pages: 90-94, ISSN: 0036-8075
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- Citations: 189
Peirce MJ, Brook M, Morrice N, et al., 2010, Themis2/ICB1 Is a Signaling Scaffold That Selectively Regulates Macrophage Toll-Like Receptor Signaling and Cytokine Production, PLOS ONE, Vol: 5, ISSN: 1932-6203
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- Citations: 27
Noerager B, Jackson PL, O'Reilly P, et al., 2010, Treatment Of Clinical Samples With Aminopeptidase Inhibitors Increases The Signal Strength And Preserves The Integrity Of A Potential COPD Biomarker, Publisher: AMER THORACIC SOC, ISSN: 1073-449X
O'Reilly P, Hardison M, Jackson PL, et al., 2010, Neutrophils contain prolyl endopeptidase and generate the neutrophil chemoattractant, PGP, from collagen, Publisher: AMER THORACIC SOC, ISSN: 1073-449X
Weathington NM, Jackson PL, Gaggar A, et al., 2010, Matrix metalloproteinase-9 cleaves Surfactant Protein-D, impairing collectin function as a bacterial agglutinin and opsonin in vitro, and such cleavage is seen during acute influenza infection in mice, Publisher: AMER THORACIC SOC, ISSN: 1073-449X
O'Reilly PJ, Hardison MT, Jackson PL, et al., 2009, Neutrophils contain prolyl endopeptidase and generate the chemotactic peptide, PGP, from collagen, JOURNAL OF NEUROIMMUNOLOGY, Vol: 217, Pages: 51-54, ISSN: 0165-5728
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- Citations: 60
Snelgrove RJ, Jackson PJ, Noerager BD, et al., 2009, A Novel Tripeptide Aminopeptidase Degrades the Neutrophil Chemoattractant PGP and Dictates the Amplitude of Neutrophilic Lung Inflammation, Publisher: AMER THORACIC SOC, ISSN: 1073-449X
Snelgrove RJ, Goulding J, Didierlaurent AM, et al., 2008, A critical function for CD200 in lung immune homeostasis and the severity of influenza infection, NATURE IMMUNOLOGY, Vol: 9, Pages: 1074-1083, ISSN: 1529-2908
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- Citations: 330
Didierlaurent A, Goulding J, Patel S, et al., 2008, Sustained desensitization to bacterial Toll-like receptor ligands after resolution of respiratory influenza infection, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 205, Pages: 323-329, ISSN: 0022-1007
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- Citations: 299
Goulding J, Snelgrove R, Saldana J, et al., 2007, Respiratory infections: do we ever recover?, Proc Am Thorac Soc, Vol: 4, Pages: 618-625, ISSN: 1546-3222
Although the outcome of respiratory infection alters with age, nutritional status, and immunologic competence, there is a growing body of evidence that we all develop a unique but subtle inflammatory profile. This uniqueness is determined by the sequence of infections or antigenic insults encountered that permanently mold our lungs through experience. This experience and learning process forms the basis of immunologic memory that is attributed to the acquired immune system. But what happens if the pathogen is not homologous to any preceding it? In the absence of cross-specific acquired immunity, one would expect a response similar to that of a subject who had never been infected with anything before. It is now clear that this is not the case. Prior inflammation in the respiratory tract alters immunity and pathology to subsequent infections even when they are antigenically distinct. Furthermore, the influence of the first infection is long lasting, not dependent on the presence of T and B cells, and effective against disparate pathogen combinations. We have used the term "innate imprinting" to explain this phenomenon, although innate education may be a closer description. This educational process, by sequential waves of infection, may be beneficial, as shown for successive viral infections, or significantly worse, as illustrated by the increased susceptibly to life-threatening bacterial pneumonia in patients infected with seasonal and pandemic influenza. We now examine what these long-term changes involve, the likely cell populations affected, and what this means to those studying inflammatory disorders in the lung.
Thorpe C, Edwards L, Snelgrove R, et al., 2007, Discovery of a vaccine antigen that protects mice from <i>Chlamydia pneumoniae</i> infection, VACCINE, Vol: 25, Pages: 2252-2260, ISSN: 0264-410X
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- Citations: 25
Gwyer E, Snelgrove R, Hussell T, 2006, The therapeutic potential of positive and negative immune cell co-stimulation during inflammation, BIOCHEMICAL SOCIETY TRANSACTIONS, Vol: 34, Pages: 1032-1036, ISSN: 0300-5127
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- Citations: 2
Humphreys IR, Edwards L, Snelgrove RJ, et al., 2006, A critical role for ICOS co-stimulation in immune containment of pulmonary influenza virus infection, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 36, Pages: 2928-2938, ISSN: 0014-2980
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- Citations: 20
Snelgrove RJ, Edwards L, Williams AE, et al., 2006, In the absence of reactive oxygen species, T cells default to a Th1 phenotype and mediate protection against pulmonary <i>Cryptococcus neoformans</i> infection, JOURNAL OF IMMUNOLOGY, Vol: 177, Pages: 5509-5516, ISSN: 0022-1767
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- Citations: 39
Shelgrove R, Gwyer E, Hussell T, 2006, Modulation of immunity to respiratory viral infection, FUTURE VIROLOGY, Vol: 1, Pages: 471-481, ISSN: 1746-0794
Snelgrove RJ, Edwards L, Rae AJ, et al., 2006, An absence of reactive oxygen species improves the resolution of lung influenza infection, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 36, Pages: 1364-1373, ISSN: 0014-2980
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- Citations: 137
Humphreys IR, Stewart GR, Turner DJ, et al., 2006, A role for dendritic cells in the dissemination of mycobacterial infection, MICROBES AND INFECTION, Vol: 8, Pages: 1339-1346, ISSN: 1286-4579
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- Citations: 88
Didierlaurent A, Snelgrove R, Edwards L, et al., 2005, TLR5 signalling alters subsequent immune responses in the lung, IMMUNOLOGY, Vol: 116, Pages: 26-26, ISSN: 0019-2805
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- Citations: 1
Snelgrove RJ, Edwards L, Barclay AN, et al., 2005, CD200 governs compartmentalization and resolution of inflammatory responses to respiratory infection, IMMUNOLOGY, Vol: 116, Pages: 103-104, ISSN: 0019-2805
Gwyer EL, Edwards L, Snelgrove RJ, et al., 2005, Parameters affecting the expression and function of the late co-stimulatory molecule OX40, IMMUNOLOGY, Vol: 116, Pages: 7-7, ISSN: 0019-2805
Henson SM, Snelgrove R, Hussell T, et al., 2005, An IL-7 fusion protein that shows increased thymopoietic ability, JOURNAL OF IMMUNOLOGY, Vol: 175, Pages: 4112-4118, ISSN: 0022-1767
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- Citations: 35
Edwards L, Williams AE, Krieg AM, et al., 2005, Stimulation via Toll-like receptor 9 reduces <i>Cryptococcus neoformans</i>-induced pulmonary inflammation in an IL-12-dependent manner, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 35, Pages: 273-281, ISSN: 0014-2980
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- Citations: 44
Williams AE, Edwards L, Humphreys IR, et al., 2004, Innate imprinting by the modified heat-labile toxin of <i>Escherichia coli</i> (LTK63) provides generic protection against lung infectious disease, JOURNAL OF IMMUNOLOGY, Vol: 173, Pages: 7435-7443, ISSN: 0022-1767
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- Citations: 56
Hussell T, Snelgrove R, Humphreys IR, et al., 2004, Co-stimulation: novel methods for preventing viral-induced lung inflammation, TRENDS IN MOLECULAR MEDICINE, Vol: 10, Pages: 379-386, ISSN: 1471-4914
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- Citations: 10
Snelgrove R, Williams A, Thorpe C, et al., 2004, Manipulation of immunity to and pathology of respiratory infections., Expert Rev Anti Infect Ther, Vol: 2, Pages: 413-426, ISSN: 1478-7210
Respiratory infections are the third leading cause of death worldwide and are a priority for vaccine development. Immune defence mechanisms are critical in recovery from most respiratory infections but the role of the immune system in causing bystander lung injury is not as well understood, and will be the focus of this review. Immune-mediated injury results from physical occlusion of the airways or the ensuing 'cytokine storm', which may spill over into the systemic circulation and cause devastating consequences. Respiratory pathogens employ numerous strategies to avoid detection by the immune system. One of these, the alteration of key surface determinants, makes the design of rational vaccines problematic. In the following review the immune compartments responsible for clinical lung disease are discussed, and current and novel strategies to reduce their potency are overviewed.
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