Imperial College London
Portrait Picture

ProfessorRobertSnelgrove

Faculty of Medicine, National Heart & Lung Institute

Professor of Respiratory Science
 
 
 
//

Contact

 

+44 (0)20 7594 8192robert.snelgrove

 
 
//

Location

 

Sir Alexander Fleming BuildingSouth Kensington Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Patel:2018:10.1183/16000617.0017-2018,
author = {Patel, DF and Snelgrove, RJ},
doi = {10.1183/16000617.0017-2018},
journal = {European Respiratory Review},
title = {The multifaceted roles of the matrikine Pro-Gly-Pro in pulmonary health and disease},
url = {http://dx.doi.org/10.1183/16000617.0017-2018},
volume = {27},
year = {2018}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Matrikines are bioactive fragments of the extracellular matrix (ECM) that are fundamental in regulating a diverse array of physiological processes. The tripeptide Proline-Glycine-Proline (PGP) is a collagen-derived matrikine that has classically been described as a neutrophil chemoattractant. In this article, we describe our current understanding of the pathways that generate, degrade and modify PGP to dictate its bioavailability and stability. Additionally, we discuss our expanding appreciation of the capacity of PGP to regulate diverse cell types and biological processes, independent of its activity on neutrophils, including a putative role in wound repair. We argue that PGP functions as a primitive and conserved damage-associated molecular pattern, which is generated during infection or injury and subsequently acts to shape ensuing inflammatory and repair processes. As a fragment of the ECM that accumulates at the epicentre of the action, PGP is perfectly positioned to focus neutrophils to the exact site required and direct a localised repair response. However, it is essential that PGP is efficiently degraded, as if this matrikine is allowed to persist then pathology can ensue. Accordingly, we discuss how this pathway is subverted in chronic lung diseases giving rise to persistent inflammation and pathological tissue remodelling.
AU  - Patel,DF
AU  - Snelgrove,RJ
DO  - 10.1183/16000617.0017-2018
PY  - 2018///
SN  - 0905-9180
TI  - The multifaceted roles of the matrikine Pro-Gly-Pro in pulmonary health and disease
T2  - European Respiratory Review
UR  - http://dx.doi.org/10.1183/16000617.0017-2018
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000437470300011&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/62072
VL  - 27
ER  -
Download