Imperial College London
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ProfessorRobertSnelgrove

Faculty of Medicine, National Heart & Lung Institute

Professor of Respiratory Science
 
 
 
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Contact

 

+44 (0)20 7594 8192robert.snelgrove

 
 
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Location

 

Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Vijayakumar:2022:10.1016/j.immuni.2022.01.017,
author = {Vijayakumar, B and Boustani, K and Ogger, PP and Papadaki, A and Tonkin, J and Orton, CM and Ghai, P and Suveizdyte, K and Hewitt, RJ and Desai, SR and Devaraj, A and Snelgrove, RJ and Molyneaux, PL and Garner, JL and Peters, JE and Shah, PL and Lloyd, CM and Harker, JA},
doi = {10.1016/j.immuni.2022.01.017},
journal = {Immunity},
pages = {542--556.e5},
title = {Immuno-proteomic profiling reveals aberrant immune cell regulation in the airways of individuals with ongoing post-COVID-19 respiratory disease.},
url = {http://dx.doi.org/10.1016/j.immuni.2022.01.017},
volume = {55},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Some patients hospitalized with acute COVID-19 suffer respiratory symptoms that persist for many months. We delineated the immune-proteomic landscape in the airways and peripheral blood of healthy controls and post-COVID-19 patients 3 to 6 months after hospital discharge. Post-COVID-19 patients showed abnormal airway (but not plasma) proteomes, with an elevated concentration of proteins associated with apoptosis, tissue repair, and epithelial injury versus healthy individuals. Increased numbers of cytotoxic lymphocytes were observed in individuals with greater airway dysfunction, while increased B cell numbers and altered monocyte subsets were associated with more widespread lung abnormalities. A one-year follow-up of some post-COVID-19 patients indicated that these abnormalities resolved over time. In summary, COVID-19 causes a prolonged change to the airway immune landscape in those with persistent lung disease, with evidence of cell death and tissue repair linked to the ongoing activation of cytotoxic T cells.
AU  - Vijayakumar,B
AU  - Boustani,K
AU  - Ogger,PP
AU  - Papadaki,A
AU  - Tonkin,J
AU  - Orton,CM
AU  - Ghai,P
AU  - Suveizdyte,K
AU  - Hewitt,RJ
AU  - Desai,SR
AU  - Devaraj,A
AU  - Snelgrove,RJ
AU  - Molyneaux,PL
AU  - Garner,JL
AU  - Peters,JE
AU  - Shah,PL
AU  - Lloyd,CM
AU  - Harker,JA
DO  - 10.1016/j.immuni.2022.01.017
EP  - 556
PY  - 2022///
SP  - 542
TI  - Immuno-proteomic profiling reveals aberrant immune cell regulation in the airways of individuals with ongoing post-COVID-19 respiratory disease.
T2  - Immunity
UR  - http://dx.doi.org/10.1016/j.immuni.2022.01.017
UR  - https://www.ncbi.nlm.nih.gov/pubmed/35151371
UR  - http://hdl.handle.net/10044/1/94155
VL  - 55
ER  -
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