Publications
315 results found
Wallace MH, Frayling IM, Clark SK, et al., 1999, Attenuated adenomatous polyposis coli: the role of ascertainment bias through failure to dye-spray at colonoscopy., Dis Colon Rectum, Vol: 42, Pages: 1078-1080, ISSN: 0012-3706
PURPOSE: The aim of this study is to show that the diagnosis of attenuated adenomatous polyposis coli must be made with caution and certainly only after adequate colonic examination with dye-spray. METHODS: Four patients thought to have attenuated adenomatous polyposis coli on the basis of family history and the identification of fewer than 100 polyps on simple colonoscopy underwent colonoscopy with dye-spray. RESULTS: All four individuals were found to have more than 100 polyps when dye-spray was used, confirming a diagnosis of classical familial adenomatous polyposis. CONCLUSIONS: The diagnosis of familial adenomatous polyposis may be missed altogether or incorrectly assigned as attenuated adenomatous polyposis coli if dye-spray is not used at colonoscopy. Patients with a family history of familial adenomatous polyposis or colorectal cancer should be considered for dye-spray before the diagnosis of familial adenomatous polyposis is excluded or one of attenuated adenomatous polyposis coli is made.
Carapeti EA, Kamm MA, McDonald PJ, et al., 1999, Randomised controlled trial shows that glyceryl trinitrate heals anal fissures, higher doses are not more effective, and there is a high recurrence rate, GUT, Vol: 44, Pages: 727-730, ISSN: 0017-5749
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- Citations: 157
Carapeti EA, Kamm MA, McDonald PJ, et al., 1999, Randomized trial of open <i>versus</i> closed day-case haemorrhoidectomy, BRITISH JOURNAL OF SURGERY, Vol: 86, Pages: 612-613, ISSN: 0007-1323
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- Citations: 50
Middleton SB, Clark SK, Frayling IM, et al., 1999, The nature of FAP-associated desmoids; Analysis of patterns of X-chromosome inactivation., Publisher: W B SAUNDERS CO-ELSEVIER INC, Pages: A463-A463, ISSN: 0016-5085
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- Citations: 1
Middleton SB, Pack K, Clark SK, et al., 1999, Measurement of telomeres in FAP-associated desmoids, Publisher: W B SAUNDERS CO-ELSEVIER INC, Pages: A463-A463, ISSN: 0016-5085
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- Citations: 1
Beveridge IG, Swain DJW, Wilkinson KH, et al., 1999, A comparison of rigid sigmoidoscopy and flexible sigmoidoscopy for surveillance of rectal polyps in familial adenomatous polyposis, GUT, Vol: 44, Pages: A142-A142, ISSN: 0017-5749
Beveridge IG, Swain DJW, Wilkinson KH, et al., 1999, A comparison of rigid sigmoidoscopy and flexible sigmoidoscopy for surveillance of rectal polyps in familial adenomatous polyposis, GASTROINTESTINAL ENDOSCOPY, Vol: 49, Pages: AB61-AB61, ISSN: 0016-5107
Beveridge IG, Swain DJW, Saunders BP, et al., 1999, Evaluation of argon plasma coagulation for the fulguration of rectal polyps in familial adenomatous polyposis, GASTROINTESTINAL ENDOSCOPY, Vol: 49, Pages: AB61-AB61, ISSN: 0016-5107
Van Laarhoven CJHM, Kamm MA, Bartram CI, et al., 1999, Relationship between anatomic and symptomatic long-term results after rectocele repair for impaired defecation, DISEASES OF THE COLON & RECTUM, Vol: 42, Pages: 204-210, ISSN: 0012-3706
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- Citations: 78
Carapeti EA, Kamm MA, Evans BK, et al., 1999, Topical phenylephrine increases anal sphincter resting pressure, BRITISH JOURNAL OF SURGERY, Vol: 86, Pages: 267-270, ISSN: 0007-1323
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- Citations: 35
Wallace MH, Phillips RKS, 1999, Preventative strategies for periampullary tumours in FAP, ANNALS OF ONCOLOGY, Vol: 10, Pages: 201-203, ISSN: 0923-7534
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- Citations: 16
Houlston R, Bevan S, Williams A, et al., 1998, Mutations in DPC4 (SMAD4) cause juvenile polyposis syndrome, but only account for a minority of cases, HUMAN MOLECULAR GENETICS, Vol: 7, Pages: 1907-1912, ISSN: 0964-6906
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- Citations: 102
Phillips RK, 1998, Botulinum toxin promoted healing and relieved symptoms of chronic anal fissure., Gut, Vol: 43, ISSN: 0017-5749
Clark SK, Smith TGPJ, Katz DE, et al., 1998, Identification and progression of a desmoid precursor lesion in patients with familial adenomatous polyposis, BRITISH JOURNAL OF SURGERY, Vol: 85, Pages: 970-973, ISSN: 0007-1323
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- Citations: 43
Scates DK, Clark SK, Phillips RK, et al., 1998, Lack of telomerase in desmoids occurring sporadically and in association with familial adenomatous polyposis, The British journal of surgery, Vol: 85, Pages: 965-969
Wallace MH, Phillips RK, 1998, Upper gastrointestinal disease in patients with familial adenomatous polyposis., Br J Surg, Vol: 85, Pages: 742-750, ISSN: 0007-1323
BACKGROUND: Upper gastrointestinal disease has become an important aspect in the management of patients with familial adenomatous polyposis (FAP). METHODS: A review of the literature was carried out using Medline. Epidemiology, pathology and treatment options are considered. RESULTS AND CONCLUSION: Despite the fact that over 90 per cent of patients with FAP develop duodenal adenomas, only 5 per cent go on to develop cancer. In the absence of methods to detect who is at risk of cancer, all patients undergo regular endoscopic surveillance at present. Chemoprevention in the form of drug therapy may be the answer to controlling the disease.
Desai DC, Murday V, Phillips RK, et al., 1998, A survey of phenotypic features in juvenile polyposis., J Med Genet, Vol: 35, Pages: 476-481, ISSN: 0022-2593
Solitary juvenile polyps are quite frequent in children, but juvenile polyposis (JP) is a rare autosomal dominant trait characterised by the occurrence of numerous polyps in the gastrointestinal tract. Extracolonic phenotypic abnormalities are well documented in patients with familial adenomatous polyposis and Peutz-Jeghers syndrome and can allow a clinical diagnosis to be made before the bowel pathology becomes available. Though described, characteristic extracolonic abnormalities have not been clearly defined in juvenile polyposis. We sought to determine whether there are consistent extracolonic phenotypic abnormalities in JP patients and how frequently this would allow diagnosis of one of the genetic syndromes known to be associated with juvenile polyposis. Twenty-two JP patients underwent clinical examination and data from one patient were obtained from case notes. Those consenting to further investigations had x rays of the skull, chest, and hands and an echocardiogram if clinically indicated. Significant extracolonic phenotypic abnormalities were present in 18 patients (14 male and four female), and included dermatological (13), skeletal (16), neurological (5), cardiopulmonary (4), gastrointestinal (3), genitourinary (4), and ocular (1) features. In five patients the diagnosis of a genetic syndrome was possible: two had Bannayan-Riley-Ruvalcaba syndrome, two had Gorlin syndrome, and one had hereditary haemorrhagic telangiectasia (HHT, also known as Osler-Rendu-Weber syndrome). Other patients had some features of these conditions and of Cowden and Simpson-Golabi-Behmel syndromes, but these were not sufficient to allow a definitive diagnosis.
Carapeti EA, Kamm MA, Phillips RKS, 1998, Topical and oral diltiazem lower the resting anal sphincter pressure, BRITISH JOURNAL OF SURGERY, Vol: 85, Pages: 80-81, ISSN: 0007-1323
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- Citations: 1
Carapeti EA, Kamm MA, McDonald PJ, et al., 1998, Randomized controlled trial of metronidazole to reduce pain after day-case haemorrhoidectomy, BRITISH JOURNAL OF SURGERY, Vol: 85, Pages: 13-13, ISSN: 0007-1323
Clark SK, Johnson-Smith TGP, Katz DE, et al., 1998, Desmoid precursor lesions, Publisher: BLACKWELL SCIENCE LTD, Pages: 711-711, ISSN: 0007-1323
Carapeti EA, Kamm MA, Evans BK, et al., 1998, Diltiazem lowers resting anal sphincter pressure: A potential low side-effect alternative to glycerl trinitrate (GTN) for fissures., GASTROENTEROLOGY, Vol: 114, Pages: A7-A7, ISSN: 0016-5085
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- Citations: 6
Carapeti EA, Kamm MA, Phillips RKS, 1998, Glyceryl trinitrate heals anal fissures, high doses do it quicker, but there is a high recurrence rate., GASTROENTEROLOGY, Vol: 114, Pages: A7-A7, ISSN: 0016-5085
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- Citations: 6
Carapeti EA, Kamm MA, McDonald PJ, et al., 1998, Randomised controlled trial of metronidazole to reduce pain after day case haemorrhoidectomy., GASTROENTEROLOGY, Vol: 114, Pages: A7-A7, ISSN: 0016-5085
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- Citations: 6
Carapeti EA, Kamm MA, Brian ER, et al., 1998, Topical phenylephrine increases anal sphincter resting pressure: A possible treatment for faecal incontinence, GASTROENTEROLOGY, Vol: 114, Pages: A731-A731, ISSN: 0016-5085
Carapeti EA, Kamm MA, Evans BK, et al., 1998, Diltiazem lowers resting anal sphincter pressure a potential low side-effect alternative to glyceryl trinitrate (GTN) for fissures, GUT, Vol: 42, Pages: A97-A97, ISSN: 0017-5749
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- Citations: 9
Carapeti EA, Kamm MA, Phillips RKS, 1998, Glyceryl trinitrate heals anal fissures, high doses do it quicker but there is a high recurrence rate, GUT, Vol: 42, Pages: A97-A97, ISSN: 0017-5749
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- Citations: 9
Carapeti EA, Kamm MA, McDonald PJ, et al., 1998, Randomised controlled trial of metronidazole to reduce pain after day case haemorrhoidectomy, GUT, Vol: 42, Pages: A97-A97, ISSN: 0017-5749
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- Citations: 9
Carapeti EA, Kamm MA, Evans B, et al., 1998, Topical phenylephrine increases anal sphincter resting pressure - A possible treatment for faecal incontinence, GUT, Vol: 42, Pages: A94-A94, ISSN: 0017-5749
Carapeti EA, Kamm MA, McDonald PJ, et al., 1998, Double-blind randomised controlled trial of effect of metronidazole on pain after day-case haemorrhoidectomy, LANCET, Vol: 351, Pages: 169-172, ISSN: 0140-6736
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- Citations: 139
Olschwang S, Markie D, Seal S, et al., 1998, Peutz-Jeghers disease: most, but not all, families are compatible with linkage to 19p13.3, JOURNAL OF MEDICAL GENETICS, Vol: 35, Pages: 42-44, ISSN: 0022-2593
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- Citations: 75
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