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@article{Thickett:2020:10.1136/bmjopen-2019-034428,
author = {Thickett, D and Voorham, J and Ryan, R and Jones, R and Coker, R and Wilson, AM and Yang, S and Ow, MYL and Raju, P and Chaudhry, I and Hardjojo, A and Carter, V and Price, DB},
doi = {10.1136/bmjopen-2019-034428},
journal = {BMJ Open},
pages = {1--10},
title = {Historical database cohort study addressing the clinical patterns prior to idiopathic pulmonary fibrosis (IPF) diagnosis in UK primary care},
url = {http://dx.doi.org/10.1136/bmjopen-2019-034428},
volume = {10},
year = {2020}
}

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TY  - JOUR
AB  - Objective To explore the clinical pathways, including signs and symptoms, and symptom progression patterns preceding idiopathic pulmonary fibrosis (IPF) diagnosis.Design and setting A historical cohort study was conducted using primary care patient records from the Optimum Patient Care Research Database.Participants Patients included were at least 30 years, had IPF diagnosis, identified via clinical-coding and free-text records and had a consultation with a chest specialist prior to IPF diagnosis.Outcome measures The signs and symptoms in the year prior to IPF diagnosis from clinical codes and free-text in primary care electronic records included: cough, dyspnoea, dry cough, weight loss, fatigue/malaise, loss of appetite, crackles and clubbed fingers. The time course of presentations of clinical features and investigations in the years prior to IPF diagnosis were mapped.Results Within 462 patients identified, the majority (77.9%) had a respiratory consultation within 365 days prior to the chest specialist visit preceding the IPF diagnosis recorded in their primary care records. The most common symptoms recorded in the 1 year prior to IPF diagnosis were dyspnoea (48.7%) and cough (40.9%); other signs and symptoms were rarely recorded (<5%). The majority of patients with cough (58.0%) and dyspnoea (55.0%) in the 1 year before IPF diagnosis had multiple recordings of the respective symptoms. Both cough and dyspnoea were recorded in 23.4% of patients in the year prior to diagnosis. Consultation rates for cough, dyspnoea and both, but not other signs or symptoms, began to increase 4 to 5 years prior diagnosis, with the sharpest increase in the last year. Cough and dyspnoea were often preceded by a reduction in measured weight over 5 years leading to IPF diagnosis.Conclusion Prolonged cough and/or progressive dyspnoea, especially if accompanied with weight loss, should signal for a referral to specialist assessment at the earliest opportunity.
AU  - Thickett,D
AU  - Voorham,J
AU  - Ryan,R
AU  - Jones,R
AU  - Coker,R
AU  - Wilson,AM
AU  - Yang,S
AU  - Ow,MYL
AU  - Raju,P
AU  - Chaudhry,I
AU  - Hardjojo,A
AU  - Carter,V
AU  - Price,DB
DO  - 10.1136/bmjopen-2019-034428
EP  - 10
PY  - 2020///
SN  - 2044-6055
SP  - 1
TI  - Historical database cohort study addressing the clinical patterns prior to idiopathic pulmonary fibrosis (IPF) diagnosis in UK primary care
T2  - BMJ Open
UR  - http://dx.doi.org/10.1136/bmjopen-2019-034428
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000561432600004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://bmjopen.bmj.com/content/10/5/e034428
UR  - http://hdl.handle.net/10044/1/104161
VL  - 10
ER  -

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Dr Robina Coker (Professor of Practice, Respiratory Medicine)

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