Imperial College London
Dr Ronald Pearce

DrRonaldPearce

Faculty of Medicine, Faculty of Medicine Centre

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

ronald.pearce

 
 
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Assistant

 

Dr Stavia Blunt +44 (0)20 3311 1182

 
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Location

 

10L15ACharing Cross HospitalCharing Cross Campus

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Summary

 

Publications

Publication Type
Year
to

97 results found

Kalaitzakis ME, Graeber MB, Gentleman SM, Pearce RKBet al., 2008, Striatal β-amyloid deposition in Parkinson disease with dementia, JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, Vol: 67, Pages: 155-161, ISSN: 0022-3069

Journal article

Kalaitzakis ME, Graeber MB, Gentleman SM, Pearce RKBet al., 2008, Striatal β-amyloid deposition in Parkinson disease with Dementia, Journal of Neuropathology and Experimental Neurology, Vol: 67, Pages: 155-161, ISSN: 0022-3069

Dementia is common in Parkinson disease (PD), although its anatomic and pathologic substrates remain undefined. Recently, striatal abnormalities in Lewy body diseases have been described, but their clinical relevance is not clear. Thirty PD cases from the United Kingdom ParkinsoÇıs Disease Society Tissue Bank were grouped as demented (PDD; n = 16) and nondemented (PD; n = 14) based on a review of clinical records. The extent of a-synuclein, tau, and amyloid A peptide (βA) deposition in the caudate nucleus, putamen, and nucleus accumbens was assessed. All cases showed severe dopaminergic striatal terminal denervation based on tyrosine hydroxylase immunohistochemistry. a-synuclein and tau deposition in the striatum were rare in both groups, but the AA burden was significantly greater in the striatum of PD cases with dementia than present in the nondemented PD group. Striatal βA deposition was type-independent of Alzheimer disease changes in the cortex and was minimal in nondemented PD cases. We conclude thatβA deposition in the striatum strongly correlates with dementia in PD. Copyright © 2008 by the American Association of Neuropathologists, Inc.

Journal article

Kalaitzakis ME, Roncaroli F, Pearce RKB, Gentleman SMet al., 2008, Non stereotypical distribution of alpha-synuclein in the spinal cord and brain of a patient with dementia with Lewy bodies (DLB), Pages: S247-S247, ISSN: 0885-3185

Conference paper

Kalaitzakis ME, Roncaroli F, Pearce RKB, Gentleman SMet al., 2008, Non-stereotypical distribution of α-synuclein in the spinal cord and brain of a patient with dementia with Lewy bodies (DLB), 12th International Congress of Parkinsons Disease and Movement Disorders, Publisher: WILEY-LISS, Pages: S247-S247, ISSN: 0885-3185

Conference paper

Moran LB, Durrenberger PF, Pearce RKB, Graeber MBet al., 2007, Two new molecular markers of lewy bodies in Parkinson disease, ABN Spring Scientific Meeting 2007, Publisher: B M J PUBLISHING GROUP, Pages: 1023-1023, ISSN: 0022-3050

Conference paper

Kalaitzakis ME, Christian LM, Graeber MB, Pearce RKB, Gentleman SMet al., 2007, New insights into the patho-anatomical basis of hallucinations in Parkinson's disease, 108th Annual Meeting of the British-Neuopathological-Society, Publisher: BLACKWELL PUBLISHING, Pages: 266-266, ISSN: 0305-1846

Conference paper

Durrenberger PF, Filiou MD, Moran LB, Pearce RKB, Graeber MBet al., 2007, The DnaJ/HSP40 chaperone family: involvement in Parkinson's disease, 108th Annual Meeting of the British-Neuopathological-Society, Publisher: BLACKWELL PUBLISHING, Pages: 255-256, ISSN: 0305-1846

Conference paper

Slonimsky A, Hickey L, Christian L, Dexter DT, Pearce RKB, Graeber MB, Moran LBet al., 2007, Expression of gamma-synuclein in Parkinson's disease, 108th Annual Meeting of the British-Neuopathological-Society, Publisher: BLACKWELL PUBLISHING, Pages: 256-256, ISSN: 0305-1846

Conference paper

Duke DC, Moran LB, Pearce RKB, Graeber MBet al., 2007, The medial and lateral substantia nigra in Parkinson's disease: mRNA profiles associated with higher brain tissue vulnerability, NEUROGENETICS, Vol: 8, Pages: 83-94, ISSN: 1364-6745

Journal article

Williams MR, Pearce RKB, Hirsch SR, Ansorge O, Thom M, Maier Met al., 2007, Changes in grey matter thickness in the crown of the primary cingulate gyrus in schizophrenia and bipolar disorder is a result of thinning of the pyramidal cell layers, 108th Annual Meeting of the British-Neuopathological-Society, Publisher: BLACKWELL PUBLISHING, Pages: 270-270, ISSN: 0305-1846

Conference paper

Williams MR, Pearce RKB, Hirsch SR, Ansorge O, Thom M, Hampton T, Maier Met al., 2007, Astrocyte abnormalities differentiate male and female schizophrenics in the anterior cingulate cortex and corpus callosum in the post-mortem brain, 108th Annual Meeting of the British-Neuopathological-Society, Publisher: BLACKWELL PUBLISHING, Pages: 269-270, ISSN: 0305-1846

Conference paper

Moran LB, Croisier E, Duke DC, Kalaitzakis ME, Roncaroli F, Deprez M, Dexter DT, Pearce RKB, Graeber MBet al., 2007, Analysis of alpha-synuclein, dopamine and parkin pathways in neuropathologically confirmed Parkinsonian nigra, ACTA NEUROPATHOLOGICA, Vol: 113, Pages: 253-263, ISSN: 0001-6322

Journal article

Kalaitzakis ME, Pearce RKB, Graeber MB, Gentleman SMet al., 2007, Anxiety in Parkinson's disease relates to limbic and brainstem alpha-synuclein pathology, 11th International Congress of Parkinsons Disease and Movement Disorders, Publisher: WILEY-LISS, Pages: S154-S155, ISSN: 0885-3185

Conference paper

Kalaitzakis ME, Graeber MB, Gentleman SM, Pearce RKBet al., 2007, Topography of α-synuclein pathology in Parkinson's disease, 11th International Congress of Parkinsons Disease and Movement Disorders, Publisher: WILEY-LISS, Pages: S7-S7, ISSN: 0885-3185

Conference paper

Kalaitzakis ME, Graeber MB, Gentleman SM, Pearce RKBet al., 2007, Striatal amyloid β plaques relate to dementia in Parkinson's disease, 11th International Congress of Parkinsons Disease and Movement Disorders, Publisher: WILEY-LISS, Pages: S155-S156, ISSN: 0885-3185

Conference paper

Williams MR, Pearce RKB, Hirsch SR, Ansorge O, Thom M, Maier Met al., 2007, Oligodendrocyte abnormalities differentiate mood and affective disorders in the anterior cingulate cortex in the post-mortem brain, NEURON GLIA BIOLOGY, Vol: 2, Pages: S72-S72, ISSN: 1740-925X

Journal article

Moran LB, Duke DC, Croisier E, Slonimsky A, Kalaitzakis M, Deprez M, Dexter DT, Pearce RK, Graeber MBet al., 2006, Whole genome expression profiling reveals involvement of the cerebral cortex in Parkinson's disease, 16th International Congress of Neuropathology, Publisher: BLACKWELL PUBLISHING, Pages: S8-S8, ISSN: 1015-6305

Conference paper

Duke DC, Moran LB, Kalaitzakis ME, Deprez M, Dexter DT, Pearce RKB, Graeber MBet al., 2006, Transcriptome analysis reveals link between proteasomal and mitochondrial pathways in Parkinson's disease, NEUROGENETICS, Vol: 7, Pages: 139-148, ISSN: 1364-6745

Journal article

Croisier E, MRes DE, Deprez M, Goldring K, Dexter DT, Pearce RKB, Graeber MB, Roncaroli Fet al., 2006, Comparative study of commercially available anti-α-synuclein antibodies, NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol: 32, Pages: 351-356, ISSN: 0305-1846

Journal article

Croisier E, Moran LB, Dexter DT, Pearce RKB, Graeber MBet al., 2006, Microglial inflammation in the parkinsonian substantia nigra: relationship to alpha-synuclein deposition (vol 2, pg 14, 2005), JOURNAL OF NEUROINFLAMMATION, Vol: 3, ISSN: 1742-2094

Journal article

Moran LB, Duke DC, Deprez M, Dexter DT, Pearce RKB, Graeber MBet al., 2006, Whole genome expression profiling of the medial and lateral substantia nigra in Parkinson's disease, 107th Meeting of the British-Neuropathological-Society, Publisher: WILEY, Pages: 222-222, ISSN: 0305-1846

Conference paper

Moran LB, Duke DC, Deprez M, Dexter DT, Pearce RKB, Graeber MBet al., 2006, Whole genome expression profiling of the medial and lateral substantia nigra in Parkinson's disease, NEUROGENETICS, Vol: 7, Pages: 1-11, ISSN: 1364-6745

Journal article

Williams MR, Pearce RKB, Hirsch SR, Ansorge O, Thom M, Maier Met al., 2006, Astrocytes abnormalities differentiate schizophrenia from affective disorders in post-mortem brain, 13th Biennial Winter Workshop on Schizophrenia Research, Publisher: ELSEVIER SCIENCE BV, Pages: 72-72, ISSN: 0920-9964

Conference paper

Kalaitzakis ME, Christian LM, Graeber MB, Pearce RK, Gentleman SMet al., 2006, Cortical, hippocampal and amygdaloid α-synuclein pathology in Parkinson's disease:: Correlation with neuropsychiatric signs, 10th International Congress of Parkinson's Disease and Movement Disorders, Publisher: WILEY-LISS, Pages: S598-S598, ISSN: 0885-3185

Conference paper

Pearce RK, Choudry T, Farrar M, Turkheimer FE, Roncaroli Fet al., 2006, Microglia activation in non-Parkinson's disease tremor, 10th International Congress of Parkinson's Disease and Movement Disorders, Publisher: WILEY-LISS, Pages: S708-S708, ISSN: 0885-3185

Conference paper

Kalaitzakis ME, Graeber MB, Gentleman SM, Pearce RKet al., 2006, Amygdala α-synuclein pathology and cardiovascular dysautonomia in Parkinson's disease, 10th International Congress of Parkinson's Disease and Movement Disorders, Publisher: WILEY-LISS, Pages: S611-S612, ISSN: 0885-3185

Conference paper

Croisier E, Elfant D, Pearce RKB, Duke DC, Dexter DT, Graeber MB, Roncaroli Fet al., 2005, Comparison of commercial anti-alpha synuclein antibodies and standardization of a protocol, 106th Annual Meeting of the British-Neuropathological-Society, Publisher: WILEY, Pages: 245-245, ISSN: 0305-1846

Conference paper

Duke DC, Moran LB, Croisier EM, Deprez M, Dexter DT, Pearce RK, Turkheimer FE, Graeber MBet al., 2005, Correlation between mitochondrial respiratory chain and ubiquitin-proteasome gene expression in the human substantia nigra, 106th Annual Meeting of the British-Neuropathological-Society, Publisher: WILEY, Pages: 222-223, ISSN: 0305-1846

Conference paper

Navan P, Findley LJ, Undy MB, Pearce RKB, Bain PGet al., 2005, A randomly assigned double-blind cross-over study examining the relative anti-parkinsonian tremor effects of pramipexole and pergolide, EUROPEAN JOURNAL OF NEUROLOGY, Vol: 12, Pages: 1-8, ISSN: 1351-5101

Journal article

Croisier E, Moran LB, Dexter DT, Pearce RKB, Graeber MBet al., 2005, Microglial inflammation in the parkinsonian substantia nigra: relationship to alpha-synuclein deposition, JOURNAL OF NEUROINFLAMMATION, Vol: 2, ISSN: 1742-2094

Journal article

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