Imperial College London


Faculty of EngineeringDepartment of Chemical Engineering

Professor of Biomaterials Engineering



+44 (0)20 7594 2070rongjun.chen Website




408ACE ExtensionSouth Kensington Campus






Date Role


Professor of Biomaterials Engineering, Department of Chemical Engineering, Imperial College London

2019 – 2022

Reader in Biomaterials Engineering, Department of Chemical Engineering, Imperial College London
2016 2019 Senior Lecturer, Department of Chemical Engineering, Imperial College London
2013 2016 Lecturer, Department of Chemical Engineering, Imperial College London
2009  2013 Group Leader and BHRC Senior Translational Research Fellow (tenure-track), University of Leeds
2007 – 2009 Postdoctoral Research Associate, Department of Chemical Engineering and Biotechnology, University of Cambridge
2006 – 2007 Postdoctoral Research Assistant, Department of Chemical Engineering and Biotechnology, University of Cambridge
2003 – 2007 PhD in Chemical Engineering, University of Cambridge, UK 
2000 – 2003 MSc in Materials Science, Tsinghua University, China
1995 – 1999 BEng in Chemical Engineering, Beijing Technology and Business University, China

Selected Publications

Journal Articles

Xiang Y, Wang B, Yang W, et al., 2024, Mitocytosis mediated by an enzyme-activable mitochondrion-disturbing polymer-drug conjugate enhances active penetration in glioblastoma therapy, Advanced Materials, ISSN:0935-9648

Liu X, Liu Y, Yang X, et al., 2023, Potentiating the immune responses of HBsAg-VLP vaccine using a polyphosphoester-based cationic polymer adjuvant, ACS Applied Materials & Interfaces, Vol:15, ISSN:1944-8244, Pages:48871-48881

Kaur A, Darvill D, Xiang S, et al., 2023, Development of nanopackaging for storage and transport of loaded lipid nanoparticles, Nano Letters, Vol:23, ISSN:1530-6984, Pages:6760-6767

Li X, Duan Z, Chen X, et al., 2023, Impairing Tumor Metabolic Plasticity via a Stable Metal‐Phenolic‐Based Polymeric Nanomedicine to Suppress Colorectal Cancer, Advanced Materials, Vol:35, ISSN:0935-9648

Zhang Y, Zhou J, Chen X, et al., 2023, Modulating tumor-stromal crosstalk via a redox-responsive nanomedicine for combination tumor therapy, Journal of Controlled Release, Vol:356, ISSN:0168-3659, Pages:525-541

Chen S, Morrison G, Liu W, et al., 2022, A pH-responsive, endosomolytic liposome functionalized with membrane-anchoring, comb-like pseudopeptides for enhanced intracellular delivery and cancer treatment, Biomaterials Science, Vol:10, ISSN:2047-4830, Pages:6718-6730

Huang Y, Jiang J, Ren J, et al., 2022, A fibrinogen-mimicking, activated-platelet-sensitive nanocoacervate enhances thrombus targeting and penetration of tissue plasminogen activator for effective thrombolytic therapy., Advanced Healthcare Materials, Vol:11, ISSN:2192-2640, Pages:1-17

Zheng X, Pan D, Zhu G, et al., 2022, A Dendritic Polymer‐Based Nanosystem Mediates Drug Penetration and Irreversible Endoplasmic Reticulum Stresses in Tumor via Neighboring Effect, Advanced Materials, Vol:34, ISSN:0935-9648

Gu L, Duan Z, Chen X, et al., 2022, A transformable amphiphilic and block polymer-dendron conjugate for enhanced tumor penetration and retention with cellular homeostasis perturbation via membrane flow., Advanced Materials, Vol:34, ISSN:0935-9648, Pages:1-14

Luo Q, Duan Z, Li X, et al., 2022, Branched polymer-based redox/enzyme-activatable photodynamic nanoagent to trigger STING-dependent immune responses for enhanced therapeutic effect, Advanced Functional Materials, Vol:32, ISSN:1616-301X, Pages:1-14

Li Y, Duan Z, Pan D, et al., 2022, Attenuating metabolic competition of tumor cells for favoring the nutritional demand of immune cells by a branched polymeric drug delivery system, Advanced Materials, Vol:35, ISSN:0935-9648, Pages:1-14

Pan D, Zheng X, Zhang L, et al., 2022, Synergistic disruption of metabolic homeostasis through hyperbranched poly(ethylene glycol) conjugates as nanotherapeutics to constrain cancer growth, Advanced Materials, Vol:34, ISSN:0935-9648

Cai H, Tan P, Chen X, et al., 2022, Stimuli-sensitive linear-dendritic block copolymer-drug prodrug as nano-platform for tumor combination therapy., Advanced Materials, Vol:34, ISSN:0935-9648, Pages:1-15

Tan P, Cai H, Wei Q, et al., 2021, Enhanced chemo-photodynamic therapy of an enzyme-responsive prodrug in bladder cancer patient-derived xenograft models, Biomaterials, Vol:277, ISSN:0142-9612, Pages:1-13

Huang Y, Gu B, Salles II, et al., 2021, Fibrinogen-mimicking, multi-arm nanovesicles for human thrombus-specific delivery of tissue plasminogen activator and targeted thrombolytic therapy, Science Advances, Vol:7, ISSN:2375-2548

Huang Y, Wang Z, Zhang G, et al., 2021, A pH/redox-dual responsive, nanoemulsion-embedded hydrogel for efficient oral delivery and controlled intestinal release of magnesium ions, Journal of Materials Chemistry B, Vol:9, ISSN:2050-750X, Pages:1888-1895

Li Y, Tan T, Zhao Y, et al., 2020, Anticancer polymers via the biginelli reaction, Acs Macro Letters, Vol:9, ISSN:2161-1653, Pages:1249-1254

Chen S, Wu L, Ren J, et al., 2020, Comb-like pseudopeptides enable very rapid and efficient intracellular trehalose delivery for enhanced cryopreservation of erythrocytes, ACS Applied Materials & Interfaces, Vol:12, ISSN:1944-8244, Pages:28941-28951

Tascini AS, Wang S, Seddon JM, et al., 2020, Fats’ love–hate relationships: a molecular dynamics simulation and hands-on experiment outreach activity to introduce the amphiphilic nature and biological functions of lipids to young students and the general public, Journal of Chemical Education, Vol:97, ISSN:0021-9584, Pages:1360-1367

Li L, Xiao B, Mu J, et al., 2019, A MnO2 nanoparticle-dotted hydrogel promotes spinal cord repair via regulating reactive oxygen species microenvironment and synergizing with mesenchymal stem cells, ACS Nano, Vol:13, ISSN:1936-0851, Pages:14283-14293

Kopytynski M, Chen S, Legg S, et al., 2019, A versatile polymer‐based platform for intracellular delivery of macromolecules, Advanced Therapeutics, Vol:3, ISSN:2366-3987, Pages:1-10

Huang Y, Yu L, Ren J, et al., 2019, An activated-platelet-sensitive nanocarrier enables targeted delivery of tissue plasminogen activator for effective thrombolytic therapy, Journal of Controlled Release, Vol:300, ISSN:0168-3659, Pages:1-12

He M, Huang L, Hou X, et al., 2019, Efficient ovalbumin delivery using a novel multifunctional micellar platform for targeted melanoma immunotherapy, International Journal of Pharmaceutics, Vol:560, ISSN:0378-5173, Pages:1-10

Dong R, Liu R, Gaffney P, et al., 2019, Sequence-defined multifunctional polyethers via liquid-phase synthesis with molecular sieving, Nature Chemistry, Vol:11, ISSN:1755-4330, Pages:136-145

Tascini AS, Noro MG, Seddon JM, et al., 2019, Mechanisms of lipid extraction from skin lipid bilayers by sebum triglycerides, Physical Chemistry Chemical Physics, Vol:21, ISSN:1463-9076, Pages:1471-1477

Wang S, Ha Y, Huang X, et al., 2018, A new strategy for intestinal drug delivery via pH-responsive and membrane-active nanogels, ACS Applied Materials & Interfaces, Vol:10, ISSN:1944-8244, Pages:36622-36627

Wang S, Chen R, 2017, pH-Responsive, Lysine-Based, Hyperbranched Polymers Mimicking Endosomolytic Cell-Penetrating Peptides for Efficient Intracellular Delivery, Chemistry of Materials, Vol:29, ISSN:0897-4756, Pages:5806-5815

Chen S, Wang S, Kopytynski M, et al., 2017, Membrane-anchoring, comb-like pseudopeptides for efficient, pH-mediated membrane destabilization and intracellular delivery, ACS Applied Materials & Interfaces, Vol:9, ISSN:1944-8244, Pages:8021-8029

Chen S, Chen R, 2016, A virus-mimicking, endosomolytic liposomal system for efficient, pH-triggered intracellular drug delivery, ACS Applied Materials & Interfaces, Vol:8, ISSN:1944-8244, Pages:22457-22467

Bachelet M, Chen R, 2016, Self-assembly of PEGylated gold nanoparticles with satellite structures as seeds, Chemical Communications, Vol:52, ISSN:1364-548X, Pages:9542-9545

Zhang W, Wang F, Wang Y, et al., 2016, pH and near-infrared light dual-stimuli responsive drug delivery using DNA-conjugated gold nanorods for effective treatment of multidrug resistant cancer cells., J Control Release, Vol:232, Pages:9-19

More Publications