Imperial College London
Alternate

ProfessorRongjunChen

Faculty of Engineering, Department of Chemical Engineering

Professor of Biomaterials Engineering
 
 
 
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Contact

 

+44 (0)20 7594 2070rongjun.chen Website

 
 
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Location

 

408ACE ExtensionSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Wang:2018:10.1021/acsbiomaterials.8b01040,
author = {Wang, S and Attah, R and Li, J and Chen, Y and Chen, R},
doi = {10.1021/acsbiomaterials.8b01040},
journal = {ACS Biomaterials Science and Engineering},
pages = {4236--4243},
title = {A pH-responsive amphiphilic hydrogel based on pseudopeptides and poly(ethylene glycol) for oral delivery of hydrophobic drugs},
url = {http://dx.doi.org/10.1021/acsbiomaterials.8b01040},
volume = {4},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Oral administration is a noninvasive and convenient drug delivery route most preferred by patients. However, poor stability in the gastrointestinal tract and low bioavailability of hydrophobic drugs has greatly limited their oral administration. To address this problem, we report a pH-responsive, amphiphilic hydrogel drug carrier based on a pseudopeptide poly(l-lysine isophthalamide) (PLP) and poly(ethylene glycol) (PEG). The hydrogels were prepared by a simple N-(3-(dimethylamino)propyl)-N′-ethyl carbodiimide hydrochloride (EDC)/N-hydroxysuccinimide (NHS) coupling reaction, and the cross-linking was confirmed by infrared spectroscopy and differential scanning calorimetry analyses. Because of the pH-responsive conformational alteration of PLP, the hydrogels were relatively hydrophobic and collapsed at acidic pH, but became hydrophilic and swollen at neutral pH. The amphiphilicity enabled the hydrogels to well retain and protect hydrophobic model drugs in the simulated gastric fluid, but efficiently release them in the simulated intestinal fluid. These results suggested that the pH-responsive amphiphilic hydrogels are promising candidates for oral delivery of hydrophobic drugs.
AU  - Wang,S
AU  - Attah,R
AU  - Li,J
AU  - Chen,Y
AU  - Chen,R
DO  - 10.1021/acsbiomaterials.8b01040
EP  - 4243
PY  - 2018///
SN  - 2373-9878
SP  - 4236
TI  - A pH-responsive amphiphilic hydrogel based on pseudopeptides and poly(ethylene glycol) for oral delivery of hydrophobic drugs
T2  - ACS Biomaterials Science and Engineering
UR  - http://dx.doi.org/10.1021/acsbiomaterials.8b01040
UR  - http://hdl.handle.net/10044/1/64040
VL  - 4
ER  -
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