Imperial College London
Alternate

ProfessorRongjunChen

Faculty of Engineering, Department of Chemical Engineering

Professor of Biomaterials Engineering
 
 
 
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Contact

 

+44 (0)20 7594 2070rongjun.chen Website

 
 
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Location

 

408ACE ExtensionSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{He:2019:10.1016/j.ijpharm.2019.01.027,
author = {He, M and Huang, L and Hou, X and Zhong, C and Bachir, ZA and Lan, M and Chen, R and Gao, F},
doi = {10.1016/j.ijpharm.2019.01.027},
journal = {International Journal of Pharmaceutics},
pages = {1--10},
title = {Efficient ovalbumin delivery using a novel multifunctional micellar platform for targeted melanoma immunotherapy},
url = {http://dx.doi.org/10.1016/j.ijpharm.2019.01.027},
volume = {560},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Cancer immunotherapy is considered to be one of the alternatives to traditional chemotherapy. It's known that foreign antigen, such as ovalbumin (OVA), can label tumor cells, leading to neoantigen recognition by cytotoxic T lymphocytes. Herein, a novel multifunctional micelle coated with PEGylated hyaluronic acid (HA) was prepared through self-assembly and electrostatic interaction. The OVA-loaded micelle with uniform size (132.1±0.2nm in diameter) exhibited favorable stability and sustained release profiles. The HA-coated micelle could target CD44-overexpressed cells and enhance the cellular uptake of OVA by 11.9 fold compared to free OVA. In vitro studies revealed that the cationic polymer, polyethyleneimine, could facilitate endosomal escape of OVA to label a tumor cell. After treatment with the OVA-loaded micelle, tumor growth in mice was significantly inhibited by 70% compared to the group treated with free OVA. All these results suggest the potential application of the immunotherapeutic micellar platform for melanoma treatment.
AU  - He,M
AU  - Huang,L
AU  - Hou,X
AU  - Zhong,C
AU  - Bachir,ZA
AU  - Lan,M
AU  - Chen,R
AU  - Gao,F
DO  - 10.1016/j.ijpharm.2019.01.027
EP  - 10
PY  - 2019///
SN  - 0378-5173
SP  - 1
TI  - Efficient ovalbumin delivery using a novel multifunctional micellar platform for targeted melanoma immunotherapy
T2  - International Journal of Pharmaceutics
UR  - http://dx.doi.org/10.1016/j.ijpharm.2019.01.027
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30677484
UR  - http://hdl.handle.net/10044/1/67095
VL  - 560
ER  -
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