Imperial College London
Alternate

ProfessorRongjunChen

Faculty of Engineering, Department of Chemical Engineering

Professor of Biomaterials Engineering
 
 
 
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Contact

 

+44 (0)20 7594 2070rongjun.chen Website

 
 
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Location

 

408ACE ExtensionSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Pan:2022:10.1002/adma.202109036,
author = {Pan, D and Zheng, X and Zhang, L and Li, X and Zhu, G and Gong, M and Kopytynski, M and Zhou, L and Yi, Y and Zhu, H and Tian, X and Chen, R and Zhang, H and Gu, Z and Gong, Q and Luo, K},
doi = {10.1002/adma.202109036},
journal = {Advanced Materials},
title = {Synergistic disruption of metabolic homeostasis through hyperbranched poly(ethylene glycol) conjugates as nanotherapeutics to constrain cancer growth},
url = {http://dx.doi.org/10.1002/adma.202109036},
volume = {34},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Combination therapy is a promising approach for effective treatment of tumors through synergistically regulating pathways. However, the synergistic effect is limited, likely by uncontrolled co-delivery of different therapeutic payloads in a single nanoparticle. Herein, we developed a combination nanotherapeutic by using two amphiphilic conjugates hyperbranched poly(ethylene glycol)-pyropheophorbide-a (Ppa) (HP-P) and hyperbranched poly(ethylene glycol)-doxorubicin (DOX) (HP-D) to construct co-assembly nanoparticles (HP-PD NPs) for controllably co-loading and co-delivering Ppa and DOX. In vitro and in vivo anti-tumor studies confirmed the synergistic effect of photodynamic therapy and chemotherapy from HP-PD NPs. Metabolic variations revealed that tumor suppression was associated with disruption of metabolic homeostasis, leading to reduced protein translation. Our study uncovers the manipulation of metabolic changes in tumor cells through disruption of cellular homeostasis using HP-PD NPs and provides a new insight into rational design of synergistic nanotherapeutics for combination therapy.
AU  - Pan,D
AU  - Zheng,X
AU  - Zhang,L
AU  - Li,X
AU  - Zhu,G
AU  - Gong,M
AU  - Kopytynski,M
AU  - Zhou,L
AU  - Yi,Y
AU  - Zhu,H
AU  - Tian,X
AU  - Chen,R
AU  - Zhang,H
AU  - Gu,Z
AU  - Gong,Q
AU  - Luo,K
DO  - 10.1002/adma.202109036
PY  - 2022///
SN  - 0935-9648
TI  - Synergistic disruption of metabolic homeostasis through hyperbranched poly(ethylene glycol) conjugates as nanotherapeutics to constrain cancer growth
T2  - Advanced Materials
UR  - http://dx.doi.org/10.1002/adma.202109036
UR  - https://onlinelibrary.wiley.com/doi/10.1002/adma.202109036
UR  - http://hdl.handle.net/10044/1/93819
VL  - 34
ER  -
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